The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Sazonov D.V.

FGBU "Federal'nyĭ nauchno-klinicheskiĭ tsentr spetsializirovannykh vidov meditsinskoĭ pomoshchi i meditsinskikh tekhnologiĭ FMBA Rossii", Moskva

Babenko L.A.

Oblastnoĭ tsentr rasseiannogo skleroza i drugikh autoimmunnykh zabolevaniĭ nervnoĭ sistemy, Gosudarstvennaia novosibirskaia oblastnaia klinicheskaia bol'nitsa;
Kabinet klinicheskikh issledovaniĭ rasseiannogo skleroza, Sibirskiĭ okruzhnoĭ meditsinskiĭ tsentr FMBA Rossii

Yarmoschuk A.V.

«Siberian District Medical Center of the Federal Medical and Biological Agency» of Russia, Novosibirsk, Russia

Didrikh E.M.

Medical center «Avicenna» group of companies «Mother and Child», Novosibirsk, Russia.

An impact of glatiramer acetate (timexon) on the signs of neurodegeneration process in the neuronal layer of the retina in patients with relapsing-remitting multiple sclerosis

Authors:

Sazonov D.V., Babenko L.A., Yarmoschuk A.V., Didrikh E.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12): 25‑30

DOI: 10.17116/jnevro201811812125

Read: 1363 times

Download PDF (RU)
Contact the author
Table of contents

AN IMPACT OF GLATIRAMER ACETATE (TIMEXON) ON THE SIGNS OF NEURODEGENERATION PROCESS IN THE NEURONAL LAYER OF THE RETINA IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS
AN IMPACT OF GLATIRAMER ACETATE (TIMEXON) ON THE SIGNS OF NEURODEGENERATION PROCESS IN THE NEURONAL LAYER OF THE RETINA IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS

To cite this article:

Sazonov DV, Babenko LA, Yarmoschuk AV, Didrikh EM. An impact of glatiramer acetate (timexon) on the signs of neurodegeneration process in the neuronal layer of the retina in patients with relapsing-remitting multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12):25‑30. (In Russ.)
https://doi.org/10.17116/jnevro201811812125

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
A pilot study of asso­ciations of markers of glial and neuronal dege­neration with executive functions in alco­hol use diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):74-79
Glial fibrillary acidic protein: is there a rela­tionship with the course of multiple scle­rosis and traumatic brain injury before the onset of multiple scle­rosis?. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):80-84
An indi­vidual approach to the diagnosis and treatment of an acute psychotic condition in a patient with a multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):97-102
Surgical treatment of seco­ndary trigeminal neuralgia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):203-209
Quality of life of patients with multiple scle­rosis in the Smolensk region. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):36-40
Low-level laser therapy in multiple scle­rosis: justification and opti­mization methods of application. (Literature review). Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(5):45-56
Obje­ctive stru­ctural and functional moni­toring of poly­peptide reti­nal neuroprotective therapy in diabetic reti­nopathy. Russian Annals of Ophthalmology. 2024;(5):97-104
Non-invasive auto­mated methods for the diagnosis of periorbital skin tumors. Russian Annals of Ophthalmology. 2024;(5):137-145
Effi­cacy of brolucizumab in the treatment of reti­nal pathologies: a review of post-marketing studies. Russian Annals of Ophthalmology. 2024;(5):154-161
Pathogenetic aspe­cts of diffuse lame­llar kera­titis after laser corneal refractive surgery. Russian Annals of Ophthalmology. 2024;(6):131-137
Abstract:

Objective. To perform a comparative study of the results of optical coherence tomography of the retina in patients with relapsing-remitting multiple sclerosis, treated with glatiramer acetate (timexon). Material and methods. The study included 19 patients (16 women and 3 men) with relapsing-remitting multiple sclerosis who were treated with the glatiramer acetate generic drug timexon (BIOCAD, Russia). Dynamic changes in the main parameters of the optical coherence tomography linked with neurodegeneration manifestations in the retina during the year of the study were evaluated. Results and conclusion. The efficacy of timexon in the progression of neurodegenerative changes in the retina was shown.

Keywords:

multiple sclerosis
optical coherence tomography
neurodegeneration
retinal nerve fiber layer
ganglion cell complex
glatiramer acetate

Authors:

Sazonov D.V.

FGBU "Federal'nyĭ nauchno-klinicheskiĭ tsentr spetsializirovannykh vidov meditsinskoĭ pomoshchi i meditsinskikh tekhnologiĭ FMBA Rossii", Moskva

Babenko L.A.

Oblastnoĭ tsentr rasseiannogo skleroza i drugikh autoimmunnykh zabolevaniĭ nervnoĭ sistemy, Gosudarstvennaia novosibirskaia oblastnaia klinicheskaia bol'nitsa;
Kabinet klinicheskikh issledovaniĭ rasseiannogo skleroza, Sibirskiĭ okruzhnoĭ meditsinskiĭ tsentr FMBA Rossii

Yarmoschuk A.V.

«Siberian District Medical Center of the Federal Medical and Biological Agency» of Russia, Novosibirsk, Russia

Didrikh E.M.

Medical center «Avicenna» group of companies «Mother and Child», Novosibirsk, Russia.

Close metadata

References:

  1. Klinicheskoe rukovodstvo «Rasseyannyi skleroz». Pod red. Guseva EI, Zavalishina IA, Boiko AN. M.: Real Taim; 2011. (In Russ.)
  2. Klinicheskoe rukovodstvo «Autoimunnye zabolevaniya v nevrologii». Pod red. Zavalishina IA, Piradova MA, Boiko AN, Nikitina SS, Spirina NN., Peresedovoy AV. M.: ROOI «Zdorovie Cheloveka»; 2014. (In Russ.)
  3. Howard J, Trevick S, Younger DS. Epidemiology of Multiple Sclerosis. Neurologic Clinics. 2016;34(4):919-939. https://doi.org/10.1016/j.ncl.2016.06.016
  4. Rieckmann P, Heidenreich F, Sailer M, Zettl UK, Zessack N, Hartung H-P, Gold R, on behalf of the REMAIN study group. Treatment de-escalation after mitoxantrone therapy: results of a phase IV, multicentre, open-label, randomized study of subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis. Therapeutic Advances in Neurological Disorders. 2012;5(1):3-12. https://doi.org/10.1177/1756285611428503
  5. Sazonov DV, Malkova NA, Bulatova EV, Ryabukhina OV. Combined therapy of aggressive remitted multiple sclerosis with mitoxantron in combination with copaxon. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2009;109(12):76-79. (In Russ.)
  6. Ramtahal J, Jacob A, Das K, Boggild M. Sequential maintenance treatment with glatiramer acetate after Mitoxantrone is safe and can limit exposure to immunosuppression in very active relapsing remitting multiple sclerosis. Journal of Neurology. 2006;253(9):1160-1164. https://doi.org/10.1007/s00415-006-0178-z
  7. Vollmer T, Panitch H, Bar-Or A, Dunn J, Freedman MS, Gazda SK, Campagnolo D, Deutsch F, Arnold DL. Glatiramer acetate after induction therapy with Mitoxantrone in relapsing multiple sclerosis. Multiple Sclerosis. 2008;14:663-670. https://doi.org/10.1177/1352458507085759
  8. Boyko AN, Lashch NYu, Sharanova SN, Zakharova MN, Trifonova OV, Simaniv TO, Lysogorskaya EV, Guryanova OE, Kotov SV, Iakushina TI, Lizhdvoy VYu, Belova YuA, Khabirov FA, Babicheva NN, Khaibullin TI, Granatov EV, Averyanova LA, Sazonov DV, Odinak MM, Bisaga GN, Trinitatsky YuV, Tsukurova LA, Ivanov RA, Shustova MS. Comparative, placebo-controlled clinical study of efficacy and safety of glatiramer acetate 20 mg in patients with relapsing-remitting multiple sclerosis: results of the first year of the study. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2016; 116(10(2)):60-67. (In Russ.) https://doi.org/10.17116/jnevro201611610261-67
  9. Evangelou N, Konz D, Esiri MM, Smith S, Palace J, Matthews PM. Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis. Brain. 2001;124:1813-1820. https://doi.org/10.1097/00041327-200206000-00040
  10. Frohman EM, Fujimoto JG, Frohman TC, Calabresi PA, Cutter G, Balcer LJ. Optical coherence tomography: a window into the mechanisms of multiple sclerosis. Nature Clinical Practice Neurology. 2008;4:664-675. https://doi.org/10.1038/ncpneuro0950
  11. Akopyan VS, Boiko AN, Davydovskaya MV, Semenova NS, Filonenko IV, Fomin AV, Tsysar’ MA. Retinal neuro-architecture in multiple sclerosis (MS): Optical coherence tomography diagnostic features (preliminary results). Oftal’mologiya. 2011;8:32-36. (In Russ.)
  12. Burkholder BM, Osborne B, Loguidice MJ, Bisker E, Frohman TC, Conger A, Ratchford JN, Warner C, Clyde E, Markowitz CE, Jacobs DA, Galetta SL, Cutter GR, Maguire MG, Calabresi PA, Balcer LJ, Frohman EM. Macular volume by optical coherence tomography as a measure of neuronal loss in multiple sclerosis. Archives Neurology. 2009;66:1366-1372. https://doi.org/10.1001/archneurol.2009.230
  13. Davydovskaya MV, Tsysar MA, Boyko AN, Akopyan VS, Semenova NS, Filonenko IV, Fomin AV, Gusev EI. Damage of macular ganglion cell complex and peripapillary retinal nerve fiber layer in multiple sclerosis. Zhurnal Nevrologii i Psikhiatrii im. Korsakova. 2012;112(2(2)): 47-51. (In Russ.)
  14. Neroev VV, Zueva MV, Tsapenko IV, Brylev LV, Zakharova MN, Lysenko VS, Zaitseva OV, Lin ED, Ampleeva MA, Eliseeva EK, Grinchenko MI, Zavalishin IA, Rezvykh SV. Neurodegenerative retinal alterations in relapsing-remitting multiple sclerosis and retrobulbar neuritis: structural and functional parallels. Rossiiskii Oftal’mologicheskii Zhurnal. 2012;4:63-68. (in Russ.)
  15. Ioileva EE, Krivosheeva MS, Smirnova MA. The results of the evaluation of patients with optic neuritis at the onset of multiple sclerosis. Vestnik OGU. 2014;12(173):143-146. (In Russ.)
  16. Sazonov DV, Babenko LA, Yarmoshchuk AV, Didrikh EM. Influence of optical neuritis on neuro degenerative process in retina ganglia cells complex in patients with recidivating disseminated sclerosis. Sibirskii Nauchnyi Meditsinskii Zhurnal. 2017;37(5):49-54. (In Russ.)
  17. Sazonov DV, Babenko LA, Yarmoshchuk AV, Didrikh EM. Opportunities for the use of optical coherence tomography of the retina to assess brain atrophy in patients with multiple sclerosis. Nevrologiya Sibiri. 2018;1(3):44-52. (In Russ.)
  18. Abalo-Lojo JM, Treus A, Arias M, Gomez-Ulla F, Gonzales F. Longitudinal study of retinal nerve fiber layer thickness changes in a multiple sclerosis patients’ cohort: a long term 5-year follow-up. Multiple Sclerosis and Related Disorders. 2018;19:124-128. https://doi.org/10.1016/j.msard.2017.11.017
  19. Saidha S, Al-Louzi O, Ratchford JN, Bhargava P, Oh J, Newsome SD, Prince JL, Pham D, Roy S, van Zijl P, Balcer LJ, Frohman EM, Reich DS, Crainiceanu C, Peter A. Calabresi PA. Optical Coherence Tomography Reflects Brain Atrophy in Multiple Sclerosis: A Four-Year Study. Annals of Neurology. 2015;78(5):801-813. https://doi.org/10.1002/ana.24487
  20. Zhostkova MA, Davydovskaya MV, Boyko AN, Akopyan VS. The three-year follow-up study of retinal changes in patients with multiple sclerosis. Zhurnal Nevrologii i Psikhiatrii im. Korsakova. 2016;116(10(2)):35-41. (In Russ.) https://doi.org/10.17116/jnevro201611610235-41
  21. Costello F, Hodge W, Pan YI, Eggenberger E, Coupland S, Kardon RH. Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography. Multiple Sclerosis. 2008;14:893-905. https://doi.org/10.1177/1352458508091367
  22. Serbecic N, Aboul-Enein F, Beutelspacher SC, Vass C, Kristoferitsch W, Lassmann H, Reitner A, Schmidt-Erfurth U. High-resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years. PLoS ONE. 2011;6(5):e19843. https://doi.org/10.1371/journal.pone.0019843
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.