Assessment of neurodevelopment in children of different gestational age with neonatal seizures

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Objective. To assess psychomotor development in infants with neonatal seizures (NS) born with different gestational age, by means of Bayley-III scales of infant and toddler development, in their corrected age of 1 year. Material and methods. The study included 52 infants, who had NS and were born with different gestational age: 28 weeks or less (n=26) — group I, 29–32 weeks (n=16) — group II, 33—36 weeks (n=3) — group III, 37—41 weeks (n=7) — group IV. The infants’ neurodevelopment was evaluated in their corrected age of 1 year by means of N. Bayley scales of infant and toddler development, third edition: Cognitive, Language, Motor, Social-Emotional, and Adaptive Behavior. Results and Conclusion. Only 17 (32,7%) of 52 examined infants did not demonstrate any developmental delay on each of five Bayley-III scales. Significant developmental delay (composite score <70) on at least one scale was revealed in 23 (44,2%) patients, including 12 (46,2%) in group I, 5 (31,3%) in group II, 6 (60%) of 10 in the combined group III—IV. In most cases, neurodevelopmental delays were attributed to only one domain and could be indicated as partial. The conclusion about global developmental retardation (the composite scores 55 or less on all five scales) was done in 3 patients, each of whom had a co-morbidity of cerebral palsy and epilepsy.

Keywords:

neonatal seizures

preterm newborns

neurodevelopment

Bayley-III scales

epilepsy

cerebral palsy

Authors:

Zavadenko A.N.

Kafedra neonatologii FUV, NIL profilaktiki i lecheniia postgipoksicheskikh sostoianiĭ u novorozhdennykh GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdrava RF

Medvedev M.I.

Degtiareva M.G.

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