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Damulin I.V.

kafedra nervnykh bolezneĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Degterev D.A.

Moscow Clinical Research Center, Moscow, Russia

Polyneuropathies in intestinal diseases

Authors:

Damulin I.V., Degterev D.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(8): 103‑107

DOI: 10.17116/jnevro201711781103-107

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To cite this article:

Damulin IV, Degterev DA. Polyneuropathies in intestinal diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(8):103‑107. (In Russ.)
https://doi.org/10.17116/jnevro201711781103-107

 
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Different aspects of polyneuropathies (PN) developed due to the deficit of group B vitamins in intestinal diseases are considered. Neurological disturbances related to intestinal diseases are caused by malabsorption that leads to the deficit of some compounds extremely important for normal cell metabolism, pathological changes of mucous coat of the stomach and intestine and higher sensitivity to the plant protein gluten. Vitamin B12 deficit can lead to a number of neurological disturbances; patients with pernicious anemia most often develop myelopathy and PN. An increase in serum vitamin B1 concentration is identified in 30—80% of patients with alcoholism. However, vitamin B1 deficit is seen also in ulcer disease, chronic gastritis, acute pancreatitis, esophageal metastatic lesions as well as in primary tumors of the stomach and intestine. Demyelinating as well as axonal PN may develop in patients with enteropathy. Gluten intolerance is the most often cause of PN in pathological changes in the intestine Possibilities of clinical and paraclinical diagnosis of these disorders are analyzed.

Keywords:

vitamin deficit
celiac disease
gluten
polyneuropathy
pathogenesis
diagnosis
treatment

Authors:

Damulin I.V.

kafedra nervnykh bolezneĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Degterev D.A.

Moscow Clinical Research Center, Moscow, Russia

List of references:

  1. Smith AG, Bromberg MB. A rational diagnostic approach to peripheral neuropathy. Journal of Clinical Neuromuscular Disease. 2003;4(4):190-198. https://doi.org/10.1097/00131402-200306000-00005
  2. Willison HJ, Winer JB. Clinical evaluation and investigation of neuropathy. Journal of Neurology, Neurosurgery and Psychiatry. 2003;74(suppl II):3-8. https://doi.org/10.1136/jnnp.74.suppl_2.ii3
  3. Farhad K, Traub R, Ruzhansky KM, Brannagan III TH. Causes of neuropathy in patients referred as «idiopathic neuropathy». Muscle & Nerve. 2016;53:856-861. https://doi.org/10.1002/mus.2496
  4. Luostarinen L, Pirttila T, Collin P. Coeliac disease presenting with neurological disorders. European Neurology. 1999;42:132-135. https://doi.org/10.1159/000008086
  5. Pengiran TS, Wills AJ, Holmes G. Neurological complications of coeliac disease. Postgraduate Medical Journal. 2002;78:393-398. https://doi.org/10.1136/pmj.78.921.393
  6. Perkin GD, Murray-Lyon I. Neurology and the gastrointestinal system. Journal of Neurology, Neurosurgery and Psychiatry. 1998;65(3):291-300. https://doi.org/10.1136/jnnp.65.3.291
  7. Wills AJ. The neurology and neuropathology of coeliac disease. Neuropathology and Applied Neurobiology. 2000;26:493-496. https://doi.org/10.1046/j.0305-1846.2000.00292.x
  8. Wills A, Hovell CJ. Neurological complications of enteric disease. Gut. 1996;39:501-504. https://doi.org/10.1136/gut.39.4.501
  9. Holmes GT. Non-malignant complications of coeliac disease. Acta Paediatrica. 1996;85(suppl 412):68-75. https://doi.org/10.1111/j.1651-2227.1996.tb14257.x
  10. Cross AH, Golumbek PT. Neurologic manifestations of celiac disease. Proven, or just a gut feeling? Neurology. 2003;60(10):1566-1568. https://doi.org/10.1212/01.wnl.0000067475.16126.5f
  11. Grossman G. Neurological complications of coeliac disease: what is the evidence? Practical Neurology. 2008;8(2):77-89. https://doi.org/10.1136/jnnp.2007.139717
  12. Henri-Bhargava A, Melmed C, Glikstein R, Schipper HM. Neurologic impairment due to vitamin E and copper deficiencies in celiac disease. Neurology. 2008;71:860-861. https://doi.org/10.1212/01.wnl.0000325473.13088.18
  13. Podolsky DK. Inflammatory bowel disease. The New England Journal of Medicine. 2002;347(6):417-429. https://doi.org/10.1056/nejmra020831
  14. Clark CM. Metabolic and nutritional disorders associated with dementia. In: Handbook of Dementing Illnesses. Ed. by J.C. Morris. New York etc.: Marcel Dekker, Inc.; 1994.
  15. Greenberg DA, Aminoff MJ, Simon RP. Clinical Neurology. Fifth edition. Chapter 1: Disorders of Consciousness. New York etc.: Lange Medical Books/McGraw-Hill; 2002.
  16. Pryse-Phillips W, Wahlund LO. Other dementias. In: Diagnosis and Management of Dementia. A Manual for Memory Disorders Teams. Ed. by G.K. Wilcock et al. Oxford: Oxford University Press; 1999.
  17. Markowitz JS, McRae AL, Sonne SC. Oral nutritional supplementation for the alcoholic patient: a brief overview. Annals of Clinical Psychiatry. 2000;12(3):153-158. https://doi.org/10.3109/10401230009147105
  18. Koike H, Mori K, Misu K, Hattori N, Ito H, Hirayama M, Sobue G. Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Neurology. 2001;56(12):1727-1732. https://doi.org/10.1212/wnl.56.12.1727
  19. Ishibashi S, Yokota T, Shiojiri T, Matunaga T, Tanaka H, Nishina K, Hirota H, Inaba A, Yamada M, Kanda T, Mizusawa H. Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency? Journal of Neurology Neurosurgery and Psychiatry. 2003;74:674-676. https://doi.org/10.1136/jnnp.74.5.674
  20. Nicolosi C, Di Leo R, Girlanda P, Messina C, Vita G. Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics? Journal of the Neurological Sciences. 2005;228(1):15-19. https://doi.org/10.1016/j.jns.2004.09.024
  21. Koike H, Sobue G. Alcoholic neuropathy. Current Opinion in Neurology. 2006;19(5):481-486. https://doi.org/10.1097/01.wco.0000245371.89941.eb
  22. McIntosh C, Chick J. Alcohol and the nervous system. Journal of Neurology Neurosurgery and Psychiatry. 2004;75(suppl 3):16-21. https://doi.org/10.1136/jnnp.2004.045708
  23. Ghezzi A, Zaffaroni M. Neurological manifestations of gastrointestinal disorders, with particular reference to the differential diagnosis of multiple sclerosis. Neurological Sciences. 2001;22(8):117-122. https://doi.org/10.1007/s100720100048
  24. Jackson JR, Eaton WW, Cascella NG, Fasano A, Kelly DL. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatr Q. 2012;83(1):91-102. https://doi.org/10.1007/s11126-011-9186-y
  25. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PR, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KA, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62(1):43-52. https://doi.org/10.1136/gutjnl-2011-301346
  26. Currie S, Hadjivassiliou M, Clark MR, Sanders DS, Wilkinson ID, Griffiths PD, Hoggard N. Should we be ‘nervous’ about coeliac disease? Brain abnormalities in patients with coeliac disease referred for neurological opinion. Journal of Neurology, Neurosurgery and Psychiatry. 2012;83(12):1216-1221. https://doi.org/10.1136/jnnp-2012-303281
  27. Freeman HJ. Neurological disorders in adult celiac disease. Canadian Journal of Gastroenterology. 2008;22(11):909-911. https://doi.org/10.1155/2008/824631
  28. Nikpour S. Neurological manifestations, diagnosis, and treatment of celiac disease: A comprehensive review. Iranian Journal of Neurology. 2012;11(2):59-64.
  29. Hadjivassiliou M, Grunewald RA, Davies-Jones GB. Gluten sensitivity: a many headed hydra. Heightened responsiveness to gluten is not confined to the gut. British Medical Journal. 1999;318(7200):1710-1711. https://doi.org/10.1136/bmj.318.7200.1710
  30. Chin RL, Sander HW, Brannagan TH, Green PHR, Hays AP, Alaedini A, Latov N. Celiac neuropathy. Neurology. 2003;60:1581-1585. https://doi.org/10.1212/01.WNL.0000063307.84039.C7
  31. Pellecchia MT, Ambrosio G, Salvatore E, Vitale C, De Michele G, Barone P. Possible gluten sensitivity in multiple system atrophy. Neurology. 2002;59(7):1114-1115. https://doi.org/10.1212/wnl.59.7.1114
  32. Bushara KO. Neurologic presentation of celiac disease. Gastroenterology. 2005;128(4):92-97. https://doi.org/10.1053/j.gastro.2005.02.018
  33. Hadjivassiliou M, Grunewald RA, Davies-Jones GB. Gluten sensitivity as a neurological illness. Journal of Neurology, Neurosurgery and Psychiatry. 2002;72(5):560-563. https://doi.org/10.1136/jnnp.72.5.560
  34. Hadjivassiliou M, Sanders DD, Aeschlimann DP. Gluten-related disorders: gluten ataxia. Digestive Diseases. 2015;33(2):264-268. https://doi.org/10.1159/000369509
  35. Vaknin A, Eliakim R, Ackerman Z, Steiner I. Neurological abnormalities associated with celiac disease. Journal of Neurology. 2004;251(11):1393-1397. https://doi.org/10.1007/s00415-004-0550-9
  36. Mitoma H, Adhikari K, Aeschlimann D, Chattopadhyay P, Hadjivassiliou M, Hampe CS, Honnorat J, Joubert B, Kakei S, Lee J, Manto M, Matsunaga A, Mizusawa H, Nanri K, Shanmugarajah P, Yoneda M, Yuki N. Consensus paper: neuroimmune mechanisms of cerebellar ataxias. The Cerebellum. 2015;15(2):213-232. https://doi.org/10.1007/s12311-015-0664-x
  37. Cicarelli G, Della Rocca G, Amboni M, Ciacci C, Mazzacca G, Filla A, Barone P. Clinical and neurological abnormalities in adult celiac disease. Neurological Sciences. 2003;24(5):311-317. https://doi.org/10.1007/s10072-003-0181-4
  38. Rosenberg NR, Vermeulen M. Should coeliac disease be considered in the work up of patients with chronic peripheral neuropathy? Journal of Neurology, Neurosurgery & Psychiatry. 2005;76(10):1415-1419. https://doi.org/10.1136/jnnp.2004.048413
  39. Chin RL, Latov N, Green PR, Brannagan III TH, Alaedini A, Sander HW. Neurologic complications of celiac disease. Journal of Clinical Neuromuscular Disease. 2004;5(3):129-137. https://doi.org/10.1097/00131402-200403000-00004
  40. Shen T-CD, Lebwohl, Verma H, Kumta N, Tennyson C, Lewis S, Scherl E, Swaminath A, Capiak KM, DiGiacomo D, Bosworth BP, Brannagan III TH, Green PR. Peripheral neuropathic symptoms in celiac disease and inflammatory bowel disease. Journal of Clinical Neuromuscular Disease. 2012;13(3):137-145. https://doi.org/10.1097/cnd.0b013e31821c55a1
  41. Brannagan TH, Hays AP, Chin SS, Sander HW, Chin RL, Magda P, Green PR, Latov N. Small-fiber neuropathy/neuronopathy associated with celiac disease: skin biopsy findings. Archives of Neurology. 2005;62(10):1574-1578. https://doi.org/10.1001/archneur.62.10.1574
  42. Gibbons CH, Freeman R. Autonomic neuropathy and coeliac disease. Journal of Neurology, Neurosurgery and Psychiatry. 2005;76:579-581. https://doi.org/10.1136/jnnp.2004.047480
  43. Nijeboer P, Bontkes HJ, Mulder CJ, Bouma G. Non-celiac gluten sensitivity. Is it in the gluten or the grain? Journal of Gastrointestinal and Liver Diseases. 2013;22(4):435-440. PMID:24369326
  44. Volta U, Caio G, Tovoli F, De Giorgio R. Non-celiac gluten sensitivity: questions still to be answered despite increasing awareness. Cellular and Molecular Immunology. 2013;10(5):383-392. https://doi.org/10.1038/cmi.2013.28
  45. Burger DC, Florin TJ. Peripheral neuropathy with infliximab therapy in inflammatory bowel disease. Inflammatory Bowel Diseases. 2009;15(12):1772. https://doi.org/10.1002/ibd.20870
  46. Anderson M. Neurology of Whipple’s disease. Journal of Neurology, Neurosurgery and Psychiatry. 2000;68(1):2-5. https://doi.org/10.1136/jnnp.68.1.2
  47. Fenollar F, Puechal X, Raoult D. Whipple’s disease. New England Journal of Medicine. 2007;356(1):55-66. https://doi.org/10.1056/nejmra062477
  48. Ratnaike RN. Whipple’s disease. Postgraduate Medical Journal. 2000;76(902):760-766. https://doi.org/10.1136/pmj.76.902.760
  49. Sung VW, Lyerly MJ, Fallon KB, Bashir K. Isolated CNS Whipple disease with normal brain MRI and false-positive CSF 14-3-3 protein: a case report and review of the literature. Brain and Behavior. 2012;2(6):838-843. https://doi.org/10.1002/brb3.97

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