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Prishchepa A.V.

GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova", Moskva

Danilov A.B.

Moskovskaia meditsinskaia akademiia im. I.M. Sechenova

Headache immunology

Authors:

Prishchepa A.V., Danilov A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(5): 94‑102

DOI: 10.17116/jnevro20171175194-102

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Table of contents

HEADACHE IMMUNOLOGY
HEADACHE IMMUNOLOGY

To cite this article:

Prishchepa AV, Danilov AB. Headache immunology. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(5):94‑102. (In Russ.)
https://doi.org/10.17116/jnevro20171175194-102

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
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Abstract:

The overview is dedicated to the neuroimmunological mechanisms of headache development and chronification. Based on the analyzed data, the authors determined the relationship between immunological parameters and duration, intensity and other characteristics of this disease. These findings confirm that immunocompetent cells can be used as headache biomarkers and predictors of treatment efficacy. Questions about the role of separate parts of the immune system in the development and maintenance of a headache require further research. Studies of humoral immunity appeared to be very promising.

Keywords:

headache immunology
cytokines
antibodies
headache biomarkers
immune dependent type of migraine
immunocompetent cells
allergic mechanisms
infectious mechanisms

Authors:

Prishchepa A.V.

GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova", Moskva

Danilov A.B.

Moskovskaia meditsinskaia akademiia im. I.M. Sechenova

Close metadata

References:

  1. Speer F. Allergy and migraine: A clinical study. Headache: The Journal of Head and Face Pain. 1971;11(2):63-67. doi:10.1111/j.1526-4610.1971.hed1102063.x
  2. Lord GDA, Duckworth JW. Complement and Immune Complex Studies in Migraine. Headache: The Journal of Head and Face Pain. 1978;18(5):255-260. doi:10.1111/j.1526-4610.1978.hed1805255.x
  3. Karpova MI. Rol' immunnoi sistemy v progressirovanii golovnoi boli napryazheniya i migreni: Dissertation. Chelyabinsk. 2011. (In Russ.). Ссылка активна на 29.08.16. Доступно по: http://www.dissercat.com/content/rol-immunnoi-sistemy-v-progressirovanii-golovnoi-boli-napryazheniya-i-migreni
  4. Gazerani P, Pourpak Z, Ahmadiani A, Hemmati A, Kazemnejad A. A Correlation Between Migraine, Histamine and Immunoglobulin E. Scandinavian Journal of Immunology. 2003;57(3):286-290. doi:10.1046/j.1365-3083.2003.01216.x
  5. Martin VT, Taylor F, Gebhardt B, Tomaszewski M, Ellison JS, Martin GV, et al. Allergy and Immunotherapy: Are They Related to Migraine Headache? Headache: The Journal of Head and Face Pain. 2010;51(1):8-20. doi:10.1111/j.1526-4610.2010.01792.x
  6. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808. doi:10.1177/0333102413485658
  7. Mal'tsev DV. Іmunnii status khvorikh na prostu mіgren' і rol' gerpetichnoї іnfektsії upatogenezі khvorobi: Dissertation. Kiїv. 2008. (In Ukr.). Ссылка активна на 29.08.16. Доступно по: http://referat.niv.ru/view/referat-medicine/113/112287.htm
  8. Nagel MA, Burns TM & Gilden D. SUNCT headaches after ipsilateral ophthalmic-distribution zoster. Journal of the Neurological Sciences. 2016;366:207-208. doi:10.1016/j.jns.2016.05.027
  9. Chen W-H, Li T-H, Lee L-H, Huang C-C. Varicella-zoster Virus Infection and Nummular Headache: A Possible Association with Epicranial Neuralgia. Internal Medicine. 2012;51(17):2439-2441. doi:10.2169/internalmedicine.51.7998
  10. Prandota J. Migraine Associated with Patent Foramen Ovale May Be Caused by Reactivation of Cerebral Toxoplasmosis Triggered by Arterial Blood Oxygen Desaturation. International Journal of Neuroscience. 2011;120(2):81-87. doi:10.3109/00207450903458647
  11. Koseoglu E, Koc I, Yazar S. Is Toxoplasma gondii a Causal Agent in Migraine? The American Journal of the Medical Sciences. 2009;338(2):120-122. doi:10.1097/maj.0b013e31819f8cac
  12. QiHong L, Jinzh X, HongYan L. Association between Chlamydia pneumoniae IgG antibodies and migraine. The Journal of Headache and Pain. 2009;10(2):121-124. doi:10.1007/s10194-009-0096-4
  13. Prandota J. Recurrent Headache as the Main Symptom of Acquired Cerebral Toxoplasmosis in Nonhuman Immunodeficiency Virus-infected Subjects With no Lymphadenopathy. American Journal of Therapeutics. 2007;14(1):63-105. doi:10.1097/01.mjt.0000208272.42379.aa
  14. Gervil M, Ulrich V, Kaprio J, Olese J, Russell MB. The relative role of genetic and environmental factors in migraine without aura. Neurology. 1999;53(5):995-995. doi:10.1212/wnl.53.5.995
  15. Mavromichalis I, Zaramboukas T, Giala MM. Migraine of gastrointestinal origin. European Journal of Pediatrics. 1995;154(5):406-410. doi:10.1007/bf02072116
  16. Hosseinzadeh M, Khosravi A, Saki K, Ranjbar R. Evaluation of Helicobacter pylori infection in patients with common migraine headache. Aoms. 2011;5:844-849. doi:10.5114/aoms.2011.25560
  17. Gasbarrini A, Gabrielli M, Fiore G, Candelli M, Bartolozzi F, De Luca A et al. Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. Cephalalgia. 2000;20(6):561-565. doi:10.1046/j.1468-2982.2000.00077.x
  18. Tunca A, Turkey C, Tekino O, Kargili A, Erbayrak M. Is Helicobacter pylori infection a risk factor for migraine? A case control study. Acta Neurologica Belgica. 2004;104:161-164. PubMed PMID: 15742606
  19. Budzyński J. The favourable effect of Helicobacter pylori eradication therapy in patients with recurrent angina-like chest pain and non-responsive to proton pump inhibitors — a preliminary study. Aoms. 2011;1:73-80. doi:10.5114/aoms.2011.20607
  20. Peres M, Zukerman E, Young W, Silberstein S. Fatigue in chronic migraine patients. Cephalalgia. 2002;22(9):720-724. doi:10.1046/j.1468-2982.2002.00426.x
  21. Okifuji A, Turk DC, Marcus DA. Comparison of Generalized and Localized Hyperalgesia in Patients With Recurrent Headache and Fibromyalgia. Psychosomatic Medicine. 1999;61(6):771-780. doi:10.1097/00006842-199911000-00009
  22. Ravindran MK, Zheng Y, Timbol C, Merck SJ, Baraniuk JN. Migraine headaches in Chronic Fatigue Syndrome (CFS): Comparison of two prospective cross-sectional studies. BMC Neurology. Springer Nature; 2011;11(1). doi:10.1186/1471-2377-11-30
  23. Fink P, Schröder A. One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders. Journal of Psychosomatic Research. 2010;68(5):415-426. doi:10.1016/j.jpsychores.2010.02.004
  24. Theoharides T, Donelan J, Kandere-Grzybowska K, Konstantinidou A. The role of mast cells in migraine pathophysiology. Brain Research Reviews. 2005;49(1):65-76 doi:10.1016/j.brainresrev.2004.11.006
  25. Gu Y, Yang DK, Spinas E, Kritas SK, Saggini A, Caraffa A, Antinolfi P, Saggini R, Conti P. Role of TNF in mast cell neuroinflammation and pain. Journal Biological Regulalators Homeostatic Agents. 2015;29(4):787-791. PubMed PMID: 26753638
  26. Ba’albaki H, Rapoport A. Mast Cells Activate the Renin Angiotensin System and Contribute to Migraine: A Hypothesis. Headache: The Journal of Head and Face Pain. 2008;48(10):1499-1505. doi:10.1111/j.1526-4610.2008.00852.x
  27. Sarchielli C. Endothelin in migraine patients. Cephalalgia. 1998;18(6):303. doi:10.1046/j.1468-2982.1998.1806303-3.x
  28. Covelli V, Maffione AB, Munno I, Jirillo E. Alterations of nonspecific immunity in patients with common migraine. Journal of Clinical Laboratory Analysis. 1990;4(1):9-15. doi:10.1002/jcla.1860040105
  29. Stirparo G, Martelletti P, Giacovazzo M, Frati L, Rinaldi-Garaci C. Impairment of cytolytic and proliferative responsiveness of peripheral blood mononuclear cells from cluster headache patients to IL-2. Pharmacological Research. 1992;26:194-195. doi:10.1016/1043-6618(92)90661-t
  30. Marchand F, Perretti M, McMahon SB. Role of the Immune system in chronic pain. Nature Review Neuroscience. 2005;6(7):521-532. doi:10.1038/nrn1700
  31. Arumugam M, Parthasarathy V. Reduction of CD4+CD25+ regulatory T-cells in migraine: Is migraine an autoimmune disorder? Journal of Neuroimmunology. 2016;290:54-59. doi:10.1016/j.jneuroim.2015.11.015
  32. Waeber C, Moskowitz MA. Migraine as an inflammatory disorder. Neurology. 2013;23:64:10(suppl 2):9-15. doi:10.1212/wnl.64.10_suppl_2.s9
  33. Sarchielli P, Alberti A, Baldi A, Coppola F, Rossi C, Pierguidi L, Floridi A, Calabresi P. Proinflammatory Cytokines, Adhesion Molecules, and Lymphocyte Integrin Expression in the Internal Jugular Blood of Migraine Patients Without Aura Assessed Ictally. Headache: The Journal of Head and Face Pain. 2006;46(2):200-207. doi:10.1111/j.1526-4610.2006.00337.x
  34. Lippi G, Meschi T, Mattiuzzi C, Borghi L, Targher G. Adiponectin and migraine: systematic review of clinical evidence. Neurological Science. 2014;20:35(8):1167-71. doi:10.1007/s10072-014-1719-3
  35. Marics B, Peitl B, Varga A, Pazmandi K, Bacsi A, Nemeth J et al. Diet-induced obesity alters dural CGRP release and potentiates TRPA1-mediated trigeminovascular responses. Cephalalgia. 2016;14. doi:10.1177/0333102416654883
  36. Hirfanoglu T, Serdaroglu A, Gulbahar O, Cansu A. Prophylactic Drugs and Cytokine and Leptin Levels in Children With Migraine. Pediatric Neurology. 2009;41(4):281-287. doi:10.1016/j.pediatrneurol.2009.04.019
  37. Yan J. Understanding the pathology of migrane: activation and sensitization of dural afferents. [dissertation] Graduate College. The University of Arizona. 2011.
  38. Plasma Cytokine Levels in Migraineurs During and Outside of Attacks. European Journal of General Medicine. 2015;31. doi:10.15197/ejgm.01255
  39. Levy D. Endogenous Mechanisms Underlying the Activation and Sensitization of Meningeal Nociceptors: The Role of Immuno-Vascular Interactions and Cortical Spreading Depression. Current Pain and Headache Reports. 2012;14:16(3):270-277. doi:10.1007/s11916-012-0255-1
  40. Johnson JL, Hutchinson MR, Williams DB, Rolan P. Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment. Cephalalgia. 2012;9:33(1):52-64. doi:10.1177/0333102412467512
  41. Boćkowski L, Śmigielska-Kuzia J, Sobaniec W, Żelazowska-Rutkowska B, Kułak W, Sendrowski K. Anti-inflammatory plasma cytokines in children and adolescents with migraine headaches. Pharmacological Reports. 2010;62(2):287-291. doi:10.1016/s1734-1140(10)70268-1
  42. Bø S, Davidsen E, Gulbrandsen P, Dietrichs E, Bovim G, Stovner L, White LR. Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache. Cephalalgia. 2009;29(3):365-372. doi:10.1111/j.1468-2982.2008.01727.x
  43. Galoyan AA. Brain Neurosecretory Cytokines. Springer Science + Business Media. 2004. doi:10.1007/978-1-4419-8893-5
  44. Watkins LR, Maier SF. Implications of immune-to-brain communication for sickness and pain. Proceedings of the National Academy of Sciences. 1999;6:96(14):7710-7713. doi:10.1073/pnas.96.14.7710
  45. Bruno PP, Carpino F, Carpino G, Zicari A. An overview on immune system and migraine. European Review for Medical and Pharmacological Sciences. 2007;11:245-248. http://www.europeanreview.org/wp/wp-content/uploads/446.pdf
  46. Lord GDA, Duckworth TW, Charlesworth JA. Complement activation in migraine. The Lancet. 1977;309(8015):781-782. doi:10.1016/s0140-6736(77)92961-0
  47. Shimomura T, Araga S, Kowa H, Takahashi K. Immunoglobulin k/Λ Ratios in Migraine and Tension-Type Headache. Psychiatry and Clinical Neurosciences. 1992;46(3):721-726. doi:10.1111/j.1440-1819.1992.tb00547.x
  48. Hanly JG, Urowitz MB, O’Keeffe AG, Gordon C, Bae S-C, Sanchez-Guerrero J, Romero-Diaz J, Clarke AE, Bernatsky S, Wallace DJ, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Petri M, Fortin PR, Gladman DD, Fessler BJ, Alarco´n GS, Bruce IN, Dooley MA, Steinsson K, Khamashta MA, Ramsey-Goldman R, Manzi S, Sturfelt GK, Nived O, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Aranow C, Mackay M, Ruiz-Irastorza G, Kalunian KC, Lim SS, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Theriault C, Thompson K, Farewell V. Headache in Systemic Lupus Erythematosus: Results From a Prospective, International Inception Cohort Study. Arthritis & Rheumatism. 2013;28:65(11):2887-2897. doi:10.1002/art.38106
  49. Stojanovich L, Kontic M, Smiljanic D, Djokovic A, Stamenkovic B, Marisavljevic D. Association between non-thrombotic neurological and cardiac manifestations in patients with antiphospholipid syndrome. Clinical Experimental Rheumatology. 2013;31(5):756-760. PMID: 23899875 [PubMed]
  50. Kyttaris VC, Juang Y-T, Tsokos GC. Immune cells and cytokines in systemic lupus erythematosus: an update. Current Opinion in Rheumatology. 2005;17(5):518-522. doi:10.1097/01.bor.0000170479.01451.ab
  51. Markus HS, Hopkinson N. Migraine and headache in systemic lupus erythematosus and their relationship with antibodies against phospholipids. Journal Neurology. 1992;239(1):39-42. doi:10.1007/bf00839210
  52. Perl A, Hanczko R, Doherty E. Assessment of Mitochondrial Dysfunction in Lymphocytes of Patients with Systemic Lupus Erythematosus. Autoimmunity. 2012;61-89. doi:10.1007/978-1-60761-720-4_4
  53. Cavestro C, Micca G, Molinari F, Bazzan M, Di Pietrantonj C, Aloi R, Pedemonte E, Iannini R, Frigeri MC, Roccatello D. Migraineurs show a high prevalence of antiphospholipid antibodies. Journal of Thrombosis and Haemostasis. 2011;9(7):1350-1354. doi:10.1111/j.1538-7836.2011.04348.x
  54. Eggers AE. An explanation of how migraine headaches can trigger relapse in systemic lupus erythematosus. Medical Hypotheses. 2013;80(5):553-555. doi:10.1016/j.mehy.2013.01.015
  55. Intiso D, Di Rienzo F, Rinaldi G, Zarrelli MM, Giannatempo GM, Crociani P, Viesti PD, Simone P. Brain MRI white matter lesions in migraine patients: is there a relationship with antiphospholipid antibodies and coagulation parameters? European Journal of Neurology. 2006;13(12):1364-1369. doi:10.1111/j.1468-1331.2006.01519.x
  56. Rajan R, Ahluwalia J, Lal V. Prothrombotic States in Migraine. Clinical and Applied Thrombosis/Hemostasis. 2013;20(8):851-856. doi:10.1177/1076029613486538
  57. Chen W-H, Chen Y-T, Lin C-S, Li T-H, Lee L-H, Chen C-J. A high prevalence of autoimmune indices and disorders in primary nummular headache. Journal of the Neurological Sciences. Elsevier BV; 2012;320(1-2):127-130. doi:10.1016/j.jns.2012.07.029
  58. Noureldine MHA, Haydar AA, Berjawi A, Elnawar R, Sweid A, Khamashta MA, Hughes GRV, Uthman H. Antiphospholipid syndrome (APS) revisited: Would migraine headaches be included in future classification criteria? Immunologic Research. 2016;16. doi:10.1007/s12026-016-8831-9
  59. Türkoğlu R, Tüzün E, İçöz S, Birişik Ö, Erdağ E, Kürtüncü M, Gulsen AD. Antineuronal Antibodies in Migraine Patients With White Matter Lesions. International Journal of Neuroscience. 2011;121(1):33-36. doi:10.3109/00207454.2010.524331
  60. Youssof MA, Reda AM, Ismail RS, Farhan MS. Prophylactic Drugs and Cytokine Levels in Migraineurs. Egyptian Journal of Neurology, Psychiatry & Neurosurgery. 2014;51(1):79.
  61. Vallejo R, Tilley DM, Vogel L, Benyamin R. The Role of Glia and the Immune System in the Development and Maintenance of Neuropathic Pain. Pain Practice. 2010;5:10(3):167-184. doi:10.1111/j.1533-2500.2010.00367.x
  62. Alpay K, Ertas M, Orhan EK, Ustay DK, Lieners C, Baykan B. Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial. Cephalalgia. 2010;10:30(7):829-837. doi:10.1177/0333102410361404
  63. Pascual J, Oterino A. IgG-mediated allergy: A new mechanism for migraine attacks? Cephalalgia. 2010;26:30(7):777-779. doi:10.1177/0333102410364856
  64. Wrobel Goldberg S, Silberstein SD. Targeting CGRP: A New Era for Migraine Treatment. CNS Drugs. 2015;29(6):443-452. doi:10.1007/s40263-015-0253-z
  65. Abstracts of the 52nd Annual Scientific Meeting of the American Headache Society. June 26-29, 2014. Los Angeles, California, USA. Headache: The Journal of Head and Face Pain. 2014;52(5):862-914. doi:10.1111/j.1526-4610.2012.02174.x
  66. Kemper R, Meijler W, Korf J, Ter Horst G. Migraine and function of the immune system: a meta-analysis of clinical literature published between 1966 and 1999. Cephalalgia. 200;21(5):549-557. doi:10.1046/j.1468-2982.2001.00196.x
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