Objective. Muscle tone disorders, including poststroke spasticity, is a frequent cause of disability. We studied the efficacy and safety of tizalud (tizanidine) in patients with arm poststroke spasticity. Material and methods. Forty-four patients were treated with tizalud and botulotoxin A in different doses in complex with rehabilitation measures or without them. Results and conclusion. The marked improvement (the decrease in spasticity, increase in muscle power and pain syndrome intensity) was noted in patients treated with the combination of tizalud and botulotoxin A.