Objective. To analyze the effect of cytoflavin on neurological functions, the level of independence in daily living tasks, psychoemotional condition and quality of life in poststroke patients. Material and methods. We have analyzed the results of treatment of 1450 stroke patients. Half of the patients received cytoflavin, and the other was treated without this drug. The functional rehabilitation was followed up using Barthel, Lindmark, Scandinavian and Merton and Sutton scales, psychoemotional condition was assessed with the Beck Depression Questionnaire and the Wakefield Depression Scale, quality of life - with the Sickness Impact Profile. Results and conclusion. Cytoflavin improved the recovery of neurological functions and social adaptation, normalized the psychoemotional condition and increased quality of life of poststroke patients.