An effect of mydocalm on muscle tone and functional rehabilitation in 1700 stroke patients (mean age 63,4 years) has been studied. Patients have been divided into two standardized groups: the basic group (850 persons who received mydocalm) and control one (850 persons who didn't receive mydocalm). The muscle tone was followed up using the Ashworth Scale, pain syndrome was assessed with the Huskisson visual analog scale and a multidimensional verbal-color pain test. The functional rehabilitation was evaluated using Barthel, Lindmark, Scandinavian and Merton & Sutton scales. Psychoemotional condition was assessed with the Beck Depression Questionnaire and the Wakefield Depression Scale, quality of life was measured by the Sickness Impact Profile. The results of the study have revealed that the use of mydocalm result in the improvement of muscle tone, decrease of pain syndrome, increase of functional rehabilitation and improvement of psychoemotional condition and the quality of life of post stroke patients. The findings of the study have demonstrated the good tolerability of mydocalm. Adverse events in the mydocalm group have been identified more rarely than in the control group.