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Kenis V.M.

The Turner Scientific Research Institute for Children’s Orthopedics, Saint-Petersburg, Russia

Baindurashvili A.G.

Turner Research Institute for Pediatric Orthopedics, Health Ministry of the Russian Federation, St. Petersburg, Russia

Dovbeshko A.G.

Korol'kova T.N.

Sankt-Peterburg Academy of Advanced Medical Training

Ivanov A.M.

FGBVOU VPO «Voenno-meditsinskaja akademija im. S.M. Kirova» MO RF, 194044 Sankt-Peterburg, ul. Akademika Lebedeva, 6

Stepanova Yu.A.

A.V. Vishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow

Protasov O.V.

Botulinum toxine treatment and the formation of antibodies to botulotoxin in patients with cerebral palsy

Authors:

Kenis V.M., Baindurashvili A.G., Dovbeshko A.G., Korol'kova T.N., Ivanov A.M., Stepanova Yu.A., Protasov O.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(9): 48‑51

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Table of contents

BOTULINUM TOXINE TREATMENT AND THE FORMATION OF ANTIBODIES TO BOTULOTOXIN IN PATIENTS WITH CEREBRAL PALSY
BOTULINUM TOXINE TREATMENT AND THE FORMATION OF ANTIBODIES TO BOTULOTOXIN IN PATIENTS WITH CEREBRAL PALSY

To cite this article:

Kenis VM, Baindurashvili AG, Dovbeshko AG, Korol'kova TN, Ivanov AM, Stepanova YuA, Protasov OV. Botulinum toxine treatment and the formation of antibodies to botulotoxin in patients with cerebral palsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(9):48‑51. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The aim of the study was to search for the association between efficacy of botulinum treatment (dysport) and the formation of antibodies to botulinum toxin in children with cerebral palsy (CP). Fourteen children with CP received dysport, 42 children (29 with CP and 13 patients with paresises of other etiologies) were not treated with this drug. No association between the presence of antibodies in blood serum and efficacy of treatment was found. However, further research of the role of antibody genesis as a factor influencing the formation of reaction to treatment is needed.

Keywords:

cerebral palsy
spasticity
botulinum toxin
antibodies to botulotoxin

Authors:

Kenis V.M.

The Turner Scientific Research Institute for Children’s Orthopedics, Saint-Petersburg, Russia

Baindurashvili A.G.

Turner Research Institute for Pediatric Orthopedics, Health Ministry of the Russian Federation, St. Petersburg, Russia

Dovbeshko A.G.

Korol'kova T.N.

Sankt-Peterburg Academy of Advanced Medical Training

Ivanov A.M.

FGBVOU VPO «Voenno-meditsinskaja akademija im. S.M. Kirova» MO RF, 194044 Sankt-Peterburg, ul. Akademika Lebedeva, 6

Stepanova Yu.A.

A.V. Vishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow

Protasov O.V.

Close metadata

References:

  1. Kenis V.M. Primenenie botulotoksinov v kompleksnom lechenii detei s DTsP. Materialy XI Rossiiskogo natsional'nogo kongressa "Chelovek i ego zdorov'e". (Sankt-Peterburg, 23 noyabrya 2006 g.). Sbornik "Chelovek i zdorov'e". St-Peterburg 2006.
  2. Klimenko V.A. Dvigatel'nye narusheniya i soputstvuyushchie sindromy u detei s tserebral'nymi paralichami, ikh korrektsiya i profilaktika v usloviyakh ortopedicheskogo statsionara: Avtoref. dis. … d-ra med. nauk. St-Peterburg 1993; 78.
  3. Umnov V.V., Kenis V.M. Sovremennye podkhody k lecheniyu lokal'noi spastichnosti u detei s tserebral'nym paralichom. Materialy nauchno-prakticheskoi konferentsii detskikh travmatologov-ortopedov Rossii (19-21 sentyabrya 2007). Ekaterinburg 2007; 282-284.
  4. Boyd R., Graham H.K. Botulinum toxin A in the management of children with cerebral palsy: indications and outcome. Eur J Neurol 1997; 4: 15-22.
  5. Dressler D., Bigalke H. Botulinum toxin antibody type A titres after cessation of botulinum toxin therapy. Movement Disorders 2002; 17: 170-173.
  6. Herrmann J., Geth K., Mall V. et al. Clinical impact of antibody formation to botulinum toxin A in children. Annals of Neurology 2004; 55: 732-735.
  7. Koman L.A., Mooney J.F., Smith B.P. et al. Management of spasticity in cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial. J Pediat Orthoped 1994; 14: 299-303.
  8. Lange O., Bigalke H., Dengler R. et al. Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A: much ado about nothing? Clin Neuropharmacol 2009; 32: 4: 213-218.
  9. Lawrence I., Moy R. An Evaluation of Neutralizing Antibody Induction During Treatment of Glabellar Lines with a New US Formulation of Botulinum Neurotoxin Type A. Aesthetic Surgery J 2009; 29: 6: 66-71.
  10. Lee S.K. Antibody-Induced Failure of Botulinum Toxin Type A Therapy in a Patient with Masseteric Hypertrophy. Dermatologic Surgery 2007; 33: 105-110.
  11. Saraph V., Zwick E.B., Steinwender C. et al. Conservative management of dynamic equinus in diplegic children treated by gait improvement surgery. J Pediatr Orthop 2001; 10: 287-292.
  12. Smith M.E., Ford C.N. Resistance to Botulinum Toxin Injections for Spasmodic Dysphonia. Arch Otolaryngol Head Neck Surg 2000; 126: 533-535.
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