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Chinikov M.A.

Patrice Lumumba Peoples’ Friendship University of Russia

Othman H.

Patrice Lumumba Peoples’ Friendship University of Russia

Voynovskiy A.E.

Vorokhobov Moscow City Clinical Hospital No. 67

Al-Ariki M.K.M.

Patrice Lumumba Peoples’ Friendship University of Russia

Kikhliarov P.V.

Vorokhobov Moscow City Clinical Hospital No. 67

Elderkhanov M.M.

Vorokhobov Moscow City Clinical Hospital No. 67

Botulinum toxin type A reducing extent of TAR procedure in patients with large postoperative hernias

Authors:

Chinikov M.A., Othman H., Voynovskiy A.E., Al-Ariki M.K.M., Kikhliarov P.V., Elderkhanov M.M.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2026;(2): 85‑92

DOI: 10.17116/hirurgia202602185

Read: 960 times

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Table of contents

BOTULINUM TOXIN TYPE A REDUCING EXTENT OF TAR PROCEDURE IN PATIENTS WITH LARGE POSTOPERATIVE HERNIAS
BOTULINUM TOXIN TYPE A REDUCING EXTENT OF TAR PROCEDURE IN PATIENTS WITH LARGE POSTOPERATIVE HERNIAS

To cite this article:

Chinikov MA, Othman H, Voynovskiy AE, Al-Ariki MKM, Kikhliarov PV, Elderkhanov MM. Botulinum toxin type A reducing extent of TAR procedure in patients with large postoperative hernias. Pirogov Russian Journal of Surgery. 2026;(2):85‑92. (In Russ.)
https://doi.org/10.17116/hirurgia202602185

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To assess the feasibility of reducing the extent of TAR repair in patients with W3 postoperative ventral hernias through preliminary BTA injections into lateral abdominal muscles.

MATERIAL AND METHODS

The study included 47 patients with midline POVH classified as W3. Eleven patients (group 1) received injections of BTA 500 U four weeks prior to scheduled unilateral TAR procedure. Group 2 (n=36) underwent standard bilateral TAR without BTA injections. Group 1 was characterized by significantly higher ASA class (p=0.011), Tanaka index (0.23±0.01 vs. 0.19±0.02; p=0.001) and fascial defect width (16.8 cm vs. 15.3 cm; p=0.01) and length (18 cm vs. 14 cm; p=0.005). Both groups were comparable in other parameters.

RESULTS

After BTA administration, fascial defect width reduced from 16.8 to 12.96 cm (p<0.001) and Tanaka index reduced from 0.23 to 0.21 (p=0.002) in group 1. Unilateral TAR was successfully performed in 72.7% of patients. Group 1 demonstrated significantly shorter surgery time (158.1±11.0 vs. 287.8±87.0 min; p<0.001) and hospital-stay (4 vs. 8 days; p=0.02) with comparable rate of severe complications. No between-group differences in quality of life were observed after 6 months (p=0.596).

CONCLUSION

Preoperative BTA administration in patients with large midline POVH allows for less extent of TAR repair.

Keywords:

Botulinum toxin
unilateral TAR procedure
ventral hernia
component separation
quality of life

Authors:

Chinikov M.A.

Patrice Lumumba Peoples’ Friendship University of Russia

Othman H.

Patrice Lumumba Peoples’ Friendship University of Russia

Voynovskiy A.E.

Vorokhobov Moscow City Clinical Hospital No. 67

Al-Ariki M.K.M.

Patrice Lumumba Peoples’ Friendship University of Russia

Kikhliarov P.V.

Vorokhobov Moscow City Clinical Hospital No. 67

Elderkhanov M.M.

Vorokhobov Moscow City Clinical Hospital No. 67

Received:

19.11.2025

Accepted:

12.12.2025

Close metadata

References:

  1. de Vries Reilingh TS, van Goor H, Rosman C, Bemelmans MH, de Jong D, van Nieuwenhoven EJ, van Engeland MI, Bleichrodt RP. «Components separation technique» for the repair of large abdominal wall hernias. J Am Coll Surg. 2003;196(1):32-37.  https://doi.org/10.1016/s1072-7515(02)01478-3
  2. Novitsky YW, Elliott HL, Orenstein SB, Rosen MJ. Transversus abdominis muscle release: a novel approach to posterior component separation during complex abdominal wall reconstruction. Am J Surg. 2012;204(5):709-716.  https://doi.org/10.1016/j.amjsurg.2012.02.008
  3. Parker SG, Halligan S, Liang MK, Muysoms FE, Adrales GL, Boutall A, de Beaux AC, Dietz UA, Divino CM, Hawn MT, Heniford TB, Hong JP, Ibrahim N, Itani KMF, Jorgensen LN, Montgomery A, Morales-Conde S, Renard Y, Sanders DL, Smart NJ, Windsor ACJ. International classification of abdominal wall planes (ICAP) to describe mesh insertion for ventral hernia repair. Br J Surg. 2020;107(3):209-217.  https://doi.org/10.1002/bjs.11400
  4. Riediger H, Köckerling F. Limitations of Transversus Abdominis Release (TAR)-Additional Bridging of the Posterior Layer And/Or Anterior Fascia Is the Preferred Solution in Our Clinical Routine If Primary Closure is Not Possible. J Abdominal Wall Surg: JAWS. 2024;3:12780. https://doi.org/10.3389/jaws.2024.12780
  5. Vogel R, Heinzelmann F, Büchler P, Mück B. Robot-Assisted Extraperitoneal Ventral Hernia Repair-Experience from the First 160 Consecutive Operations with Lateral eTEP and eTAR Techniques. J Abdominal Wall Surg: JAWS. 2024;3:13055. https://doi.org/10.3389/jaws.2024.13055
  6. Jacombs A, Elstner K, Rodriguez-Acevedo O, Read JW, Ho-Shon K, Wehrhahn M, Salazar K, Ibrahim N. Seven years of preoperative BTA abdominal wall preparation and the Macquarie system for surgical management of complex ventral hernia. Hernia. 2022;6(1):109-121.  https://doi.org/10.1007/s10029-021-02428-2
  7. Ibarra-Hurtado TR, Nuño-Guzmán CM, Echeagaray-Herrera JE, Robles-Vélez E, de Jesús González-Jaime J. Use of botulinum toxin type a before abdominal wall hernia reconstruction. World J Surg. 2009;33(12):2553-2556. https://doi.org/10.1007/s00268-009-0203-3
  8. Zendejas B, Khasawneh MA, Srvantstyan B, Jenkins DH, Schiller HJ, Zielinski MD. Outcomes of chemical component paralysis using botulinum toxin for incisional hernia repairs. World J Surg. 2013;37(12):2830-2837. https://doi.org/10.1007/s00268-013-2211-6
  9. Toma M, Oprea V, Grad O, Staines H, Bucuri CE, Andercou O, Gherghinescu M, Molnar C. Early outcomes of open anterior versus posterior components separation with transversus abdominis release for large median incisional hernias: a retrospective stepwise analysis. Hernia. 2024;28(3):803-813.  https://doi.org/10.1007/s10029-023-02920-x
  10. Zielinski MD, Goussous N, Schiller HJ, Jenkins D. Chemical components separation with botulinum toxin A: a novel technique to improve primary fascial closure rates of the open abdomen. Hernia. 2013;17(1):101-107.  https://doi.org/10.1007/s10029-012-0995-1
  11. Wegdam JA, de Vries Reilingh TS, Bouvy ND, Nienhuijs SW. Prehabilitation of complex ventral hernia patients with Botulinum: a systematic review of the quantifiable effects of Botulinum. Hernia. 2021;25(6):1427-1442. https://doi.org/10.1007/s10029-020-02333-0
  12. Timmer AS, Claessen JJM, Atema JJ, Rutten MVH, Hompes R, Boermeester MA. A systematic review and meta-analysis of technical aspects and clinical outcomes of botulinum toxin prior to abdominal wall reconstruction. Hernia. 2021;25(6):1413-1425. https://doi.org/10.1007/s10029-021-02499-1
  13. Laurens JR, Foster A, Hardley A. Closing Difficult Laparostomies with the Aid of Botulinum Toxin A: An Audit of 12 Cases. Cureus. 2021;13(3):e14066. https://doi.org/10.7759/cureus.14066
  14. De Jesus LE, Leve TC, Fulgencio C, et al. Botulinum toxin abdominal wall injection and post-omphalocele ventral hernia repair: database and proposal of a protocol. Ann Pediatr Surg. 2020;16(1):56.  https://doi:10.1186/s43159-020-00058-4
  15. Palmisano EM. Application of Botulinum Toxin A as a preoperative adjuvant technique in large abdominal wall defects. Acta Sci Clin Case Rep. 2021;2(3):22-24.  https://actascientific.com/ASCR/pdf/ASCR-02-0105.pdf
  16. Fagien S, Avelar RL, Cox SE, Joseph JH, Kaufman-Janette J, Marcus KA. Safety and Duration of Effect of 40-Unit PrabotulinumtoxinA-xvfs for the Treatment of Moderate to Severe Glabellar Lines in Adult Patients: A Phase II, Multicenter, Randomized, Double-Blind, Active-Controlled Trial. Aesthetic Surg J. 2024;44(9):987-1000. https://doi.org/10.1093/asj/sjae051
  17. Ayoub N. Botulinum Toxin Therapy: A Comprehensive Review on Clinical and Pharmacological Insights. J Clin Med. 2025;14(6):2021. https://doi.org/10.3390/jcm14062021
  18. Deerenberg EB, Harlaar JJ, Steyerberg EW, Lon HE, van Doorn HC, Heisterkamp J, Wijnhoven BP, Schouten WR, Cense HA, et al. Small bites versus large bites for closure of abdominal midline incisions (STITCH): a double-blind, multicentre, randomised controlled trial. Lancet (London, England). 2015;386(10000):1254-1260. https://doi.org/10.1016/S0140-6736(15)60459-7
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