Efficacy of cortexin as a cerebral protector and stress-limiting drug in acute cerebral pathology of newborns, severe cranial-brain damage, infection encephalitis has been confirmed during prospective placebo-controlled trials. Early administration of cortexin had the most useful effects that confirm the rule of "gold hour". Cortexin, if used timely, may be regarded as the adjuvant of means of intensive treatment of acute cerebral insufficiency.