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Aniol V.A.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Novitskaia Iu.

Gerofarm, LLC

Borodina T.N.

A.V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences

Bukreeva T.V.

A.V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences

Lazareva N.A.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Moiseeva Iu.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Onufriev M.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Stepanichev M.Iu.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Yakovlev A.A.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Gekht A.B.

N.I. Pirogov Russian State Medical University

Granstrem O.K.

Gerofarm, LLC

Gulyaeva N.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Evaluation of antiepileptic effects of cortexin in a model of convulsions

Authors:

Aniol V.A., Novitskaia Iu., Borodina T.N., Bukreeva T.V., Lazareva N.A., Moiseeva Iu.V., Onufriev M.V., Stepanichev M.Iu., Yakovlev A.A., Gekht A.B., Granstrem O.K., Gulyaeva N.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12): 68‑73

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Table of contents

EVALUATION OF ANTIEPILEPTIC EFFECTS OF CORTEXIN IN A MODEL OF CONVULSIONS
EVALUATION OF ANTIEPILEPTIC EFFECTS OF CORTEXIN IN A MODEL OF CONVULSIONS

To cite this article:

Aniol VA, Novitskaia Iu, Borodina TN, et al. Evaluation of antiepileptic effects of cortexin in a model of convulsions. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(12):68‑73. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

We studied antiepileptic effects of cortexin administered in doses 0,015, 0,15 and 1,0 mg/kg intraperitoneally in solution or intranasally in the complex with nanoparticles in a model of acute and chronic convulsions in rats induced by pentylenetetrazole. In the model of epileptic status, the long-term preliminary administration of cortexin had no effect on convulsions while in the model of chronic convulsions (temporal epilepsy), cortexin had a marked dose-dependent antiepileptic effect. The influence of cortexin on neuroplasticity and its clinical potential are discussed.

Keywords:

epilepsy
model of epileptogenesis
cortexin

Authors:

Aniol V.A.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Novitskaia Iu.

Gerofarm, LLC

Borodina T.N.

A.V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences

Bukreeva T.V.

A.V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences

Lazareva N.A.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Moiseeva Iu.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Onufriev M.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Stepanichev M.Iu.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Yakovlev A.A.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Gekht A.B.

N.I. Pirogov Russian State Medical University

Granstrem O.K.

Gerofarm, LLC

Gulyaeva N.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

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