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Izzati-zade K.F.

Kafedra nevrologii im. prof. V.P. Pervushina, kafedra gistologii lechebnogo fakul'teta Permskoĭ gosudarstvennoĭ meditsinskoĭ akademii im. akad. E.A. Vagnera

Chetvertnykh V.A.

Shutov A.A.

The morphometric analysis of serotonin granules of platelets in migraine

Authors:

Izzati-zade K.F., Chetvertnykh V.A., Shutov A.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(10): 58‑61

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To cite this article:

Izzati-zade KF, Chetvertnykh VA, Shutov AA. The morphometric analysis of serotonin granules of platelets in migraine. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(10):58‑61. (In Russ.)

 
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The serotonin hypothesis of migraine attack is based on a phenomenon of fast and significant decreasing of serotonin granules in blood platelets. The morphometric analysis was used to study area, diameter, length and wideness of platelet serotonin granules in 20 migraine patients during a headache attack and in an interparoxysmal period. We found that the area of serotonin granule surface in platelets was 0.231±0.595 mcm during the migraine attack that was significantly higher than that during the interparoxysmal period (0.205±0.037 mcm) and in the platelets of healthy controls (0.190±0.028 mcm) (n=10). The study has shown that during migraine attack serotonin granules are undergone also structural changes.

Keywords:

migraine
serotonin
platelets

Authors:

Izzati-zade K.F.

Kafedra nevrologii im. prof. V.P. Pervushina, kafedra gistologii lechebnogo fakul'teta Permskoĭ gosudarstvennoĭ meditsinskoĭ akademii im. akad. E.A. Vagnera

Chetvertnykh V.A.

Shutov A.A.

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