The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Izzati-zade K.F.

Kafedra nevrologii im. prof. V.P. Pervushina, kafedra gistologii lechebnogo fakul'teta Permskoĭ gosudarstvennoĭ meditsinskoĭ akademii im. akad. E.A. Vagnera

Chetvertnykh V.A.

Shutov A.A.

The morphometric analysis of serotonin granules of platelets in migraine

Authors:

Izzati-zade K.F., Chetvertnykh V.A., Shutov A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(10): 58‑61

Read: 1980 times

Download PDF (RU)
Contact the author
Table of contents

THE MORPHOMETRIC ANALYSIS OF SEROTONIN GRANULES OF PLATELETS IN MIGRAINE
THE MORPHOMETRIC ANALYSIS OF SEROTONIN GRANULES OF PLATELETS IN MIGRAINE

To cite this article:

Izzati-zade KF, Chetvertnykh VA, Shutov AA. The morphometric analysis of serotonin granules of platelets in migraine. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(10):58‑61. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Oxidative stress in the pathogenesis of chro­nic headache. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):35-40
The rela­tionship of diet and nutrition with the frequency of migraine atta­cks. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):30-35
The role of gene­tic poly­morphisms in folate meta­bolism genes in the mani­festation of migraine in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):47-52
Biochemical features of migraine pathogenesis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):21-26
Morning headaches in patients with obstructive sleep apnea syndrome: Pathogenesis, differential diagnosis, and treatment. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):92-97
The blood content of 25-OH vita­min D and biogenic amines in resi­dents of Arkhangelsk city. Russian Journal of Preventive Medi­cine. 2024;(11):108-114
Recu­rrent pain syndromes in adolescents of different ages. Russian Journal of Pain. 2025;(2):24-31
Prophylactic treatment of migraine in real clinical practice. Russian Journal of Pain. 2025;(2):63-69
Biofeedback in complex therapy of pain syndromes. Russian Journal of Pain. 2025;(2):70-75
Vascular endo­thelial growth factor in episodic and chro­nic migraine: new approaches to unde­rstanding pathogenesis. Russian Journal of Pain. 2025;(3):17-21
Abstract:

The serotonin hypothesis of migraine attack is based on a phenomenon of fast and significant decreasing of serotonin granules in blood platelets. The morphometric analysis was used to study area, diameter, length and wideness of platelet serotonin granules in 20 migraine patients during a headache attack and in an interparoxysmal period. We found that the area of serotonin granule surface in platelets was 0.231±0.595 mcm during the migraine attack that was significantly higher than that during the interparoxysmal period (0.205±0.037 mcm) and in the platelets of healthy controls (0.190±0.028 mcm) (n=10). The study has shown that during migraine attack serotonin granules are undergone also structural changes.

Keywords:

migraine
serotonin
platelets

Authors:

Izzati-zade K.F.

Kafedra nevrologii im. prof. V.P. Pervushina, kafedra gistologii lechebnogo fakul'teta Permskoĭ gosudarstvennoĭ meditsinskoĭ akademii im. akad. E.A. Vagnera

Chetvertnykh V.A.

Shutov A.A.

Close metadata

References:

  1. Amelin A.V., Ignatov Yu.D., Skoromets A.A. Migren' (patogenez, klinika i lechenie). St-Peterburg: Med izd-vo 2001; 199.
  2. Ashmarin I.P. Biokhimiya mozga. St-Peterburg 1999; 328: 13.
  3. Bolevye sindromy v nevrologicheskoi praktike. Pod red. chl.-korr. RAMN A.M. Veina. M: MedPress 1999; 365.
  4. Vein A.M., Kolosova O.A. Golovnaya bol'. M 1994; 286.
  5. Gromova E.A. Serotonin i ego rol' v organizme. M: Meditsina 1996; 182.
  6. Karlov V.A., Yakhno N.N. Migren', puchkovaya golovnaya bol', golovnaya bol' napryazheniya. V kn.: Bolezni nervnoi sistemy. M: Meditsina 1995; 2: 325-337.
  7. Lili R. Patogistologicheskaya tekhnika i prakticheskaya gistokhimiya. Per. s angl. M: Mir 1969; 845.
  8. Otellin V.A., Kurchenko R.P., Gilerovich E.G. Strukturnye osnovy uchastiya serotoninergicheskoi sistemy v integrativnoi deyatel'nosti mozga: Sb. st. M 1988; 136-138.
  9. Prusinskii A. Migren'. M 1979; 160.
  10. Sarkisov D.S., Perov Yu.Ya. Mikroskopicheskaya tekhnika: rukovodstvo dlya vrachei i laborantov. M: Meditsina 1996; 389.
  11. Khaulike I. Vegetativnaya nervnaya sistema. Bukharest: Meditsinskoe izdatel'stvo 1978; 121-132.
  12. Shutov A.A., Izzati-zade K.F. Vozmozhnosti metoda opredeleniya svyazannogo serotonina v trombotsitakh perifericheskoi krovi dlya diagnostiki pristupa migreni. Klinicheskaya laboratornaya diagnostika 2002; 9: 39.
  13. Antony M., Hinterberger N., Lance J.W. Plasma serotonin in migraine and stress. Arch Neurol 1967; 16: 544.
  14. Antony M., Hinterberger H., Lance J.W. The possible relationship of serotonin to the migrane syndrome. Res Clin Stad Headache 1969; 2: 295-307.
  15. Dahlstrom A., Fuxe K. Evidence for the existence of monoamine neurons in the central nervous system. Acta Physiol Scand 1965; 64: 1-85.
  16. Fozard J.R. Serotonin, migrane and platelets. Progressive Pharmacol 1982; 414: 135-146.
  17. Hamlin E., Fisher E.J. The synthesis of 5-HT. Amer Chem Soc 1951; 73: 10: 3007-5008.
  18. Kimball R.W., Friedman A.P., Vallegjo E. Effect of serotonin in migraine patients. Neurology 1960; 10: 107-111.
  19. Lance J.W., Anthony M., Gonsci A. Serotonin, the carotid body, and cranial vessels in migrane. Arch Neurol 1967; 16: 553.
  20. Lance J.W. Fifty years of migraine research. Aust NZ J Med 1988; 18: 311-317.
  21. Lancer J.W. Mechanism and management of headache. London 1982; 86.
  22. Martin G.R. Vascular receptors for 5 Hydroxitriptamine: Distribution, function, and classification. Pharmacol Ther 1994; 62: 283.
  23. Mayeux R., Stern Y., Sano M. et al. The relationships of serotonin to depression in Parkinson, s disease. Movement disorders 1988; 3: 3: 237-244.
  24. Olanow C., Ray L., Watts M., Williams C. An algorithm (decision tree) for the management of Parkinson, s disease (2001): treatment guidelines. Neurology 2001; 56: 11: Suppl 5: 1-88.
  25. Ostfeld A.M., Wolff H.G. Studies on headache: arterenol (norepinepherine) and vascular headache of the migrane type. Arch Neurol Psychiat 1955; 74: 131.
  26. Rapport M., Green A., Page J.J. Serum vasoconstrictor Serotonin. Biol Chem 1949; 176: 1243-1251.
  27. Rapport M. Serum vasoconstrictor Serotonin presence of creatine in the complex. A proposed structure of the vasoconstrictor principle. Biol Chem 1949; 180: 961-969.
  28. Sicurety F., Testi A., Anselmi B. Biochemical investigation in headache. Int Arch Allergy Appl Immunol 1995; 55.
  29. Stahl S.M. Platelets as pharmacological models for the receptors and biochemistry of monoaminergic neurons the platelets. Physiology and Pharmacology. Eds G.L. Longenesker. Academic Press INC 1985; 308-334.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.