Study of adequacy of vitamin D, the lack of which plays an important role in the development of many chronic conditions, along with biogenic amines, involved in the development of seasonal affective disorders as well, of apparently healthy residents of Arkhangelsk, characterized by the low level of insolation and the presence of contrast photoperiodicity throughout the year, seems urgent.

OBJECTIVE

To determine the seasonal dynamics of vitamin D and biogenic amines concentrations in the blood of apparently healthy men and women of working age and to establish the existing features for further use in preventive and clinical medicine.

MATERIAL AND METHODS

The prospective study involved 40 people (20 men and 20 women) aged 25—44 years, living in Arkhangelsk. Blood levels of 25-OH vitamin D, serotonin, dopamine, noradrenaline, adrenaline were determined in the examined subjects during the year (March, June, September, December).

RESULTS

It has been established in the female sample that the maximum blood levels of vitamin D were observed in the period of maximum length of daylight (June), and the minimum — in the period of minimum one (December) with the presence of 85% of insufficient and deficient conditions. In men, peak vitamin D blood concentrations were «shifted» for one season, and the highest concentration of vitamin D was registered in the period of day length reduction (September), and the lowest levels — in the period of daylight increase (March). Men had a minimum serotonin level in the spring, while women had a maximum one.

CONCLUSIONS

It has been established that the critical period of the year for vitamin D blood level in men is spring (March), in women — winter (December). Thus, the annual dynamics of vitamin D level in the blood is associated with changes of serotonin level in men, and women have high noradrenaline and adrenaline levels in winter on the background of low vitamin D and serotonin levels.