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Rogatkin S.O.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Volodin N.N.

Degtiareva M.G.

Grebennikova O.V.

Marganiia M.Sh.

Serova N.D.

Current approaches to cerebroprotective treatment of premature newborns in reanimation and intensive care departments

Authors:

Rogatkin S.O., Volodin N.N., Degtiareva M.G., Grebennikova O.V., Marganiia M.Sh., Serova N.D.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(1): 27‑32

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CURRENT APPROACHES TO CEREBROPROTECTIVE TREATMENT OF PREMATURE NEWBORNS IN REANIMATION AND INTENSIVE CARE DEPARTMENTS
CURRENT APPROACHES TO CEREBROPROTECTIVE TREATMENT OF PREMATURE NEWBORNS IN REANIMATION AND INTENSIVE CARE DEPARTMENTS

To cite this article:

Rogatkin SO, Volodin NN, Degtiareva MG, Grebennikova OV, Marganiia MSh, Serova ND. Current approaches to cerebroprotective treatment of premature newborns in reanimation and intensive care departments. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(1):27‑32. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

This work was conducted in the frames of a multicenter clinical trial. The aim was to study efficacy of cytoflavin (infusion solution) in the prevention and treatment of posthypoxic CNS lesions in premature newborns. The study included 120 premature newborns (gestation period 28-36 weeks) who was born in severe distress and needed the intensive therapy after primary reanimation measures. Cytoflavin was prescribed in the first 2-4 h after the delivery to 61 newborns. The control group included 59 newborns who did not receive the drug. To assess treatment efficacy, the determination of some plasma neurospecific proteins (GFAP, NSE, MBP) was carried out along with standard clinical/instrumental and laboratory monitoring. The results revealed the marked cerebroprotective effect of cytoflavin. The significantly higher rate of normalization of KOC, pO2, PCO2 and elimination of lactate acidosis that led to the reduction of severity and frequency of ischemic and hemorrhagic CNS lesions as well as lower levels of plasma neurospecific proteins were seen in the main group compared to the control one.

Keywords:

premature newborns
cerebral hypoxia-ischemia
intensive therapy
cerebroprotective treatment
neurospecific proteins
GFAP
NSE
MBP
cytoflavin

Authors:

Rogatkin S.O.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Volodin N.N.

Degtiareva M.G.

Grebennikova O.V.

Marganiia M.Sh.

Serova N.D.

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References:

  1. Afanas'ev V.V. Tsitoflavin v intensivnoi terapii: Posobie dlya vrachei. St-Peterburg 2005; 36.
  2. Blinov D.V. Immunofermentnyi analiz neirospetsificheskikh antigenov v otsenke pronitsaemosti gematoentsefalicheskogo bar'era pri gipoksicheski-ishemicheskikh porazheniyakh TsNS v perinatal'nom periode (kliniko-eksperimental'noe issledovanie): Avtoref. dis. … kand. med. nauk. M 2004.
  3. Bul'on V.V., Khnychenko L.S., Sapronov N.S. Korrektsiya posledstvii postishemicheskogo reperfuzionnogo povrezhdeniya golovnogo mozga tsitoflavinom. Byul eksperim biol 2000; 129: 2: 149-151.
  4. Volodin N.N., Rogatkin S.O., Medvedev M.I. Aktual'nye problemy perinatal'noi nevrologii na sovremennom etape. Zhurn nevrol i psikhiat 2001; 101: 7: 4-9.
  5. Volodin N.N., Rogatkin S.O. Sovremennye podkhody k kompleksnoi terapii perinatal'nykh porazhenii TsNS u novorozhdennykh. Farmateka 2004; 1: 72-83.
  6. Gurina O.I. Monoklonal'nye antitela k neirospetsificheskim antigenam. Poluchenie, immunokhimicheskii analiz, issledovanie pronitsaemosti gematoentsefalicheskogo bar'era: Avtoref. dis. … d-ra med. nauk. M 2005.
  7. Zarzhetskii Yu.V., Mutuskina E.A., Trubina I.E. i dr. Vliyanie suktsinata natriya na funktsional'nye, biokhimicheskie i morfologicheskie pokazateli vosstanovleniya TsNS u krys posle 10-minutnoi ostanovki krovoobrashcheniya. M - Pushchino 1997; 96-103.
  8. Kondrasheva M.N. Mekhanizmy fiziologicheskoi aktivnosti yantarnoi kisloty i rekomendatsii k ee primeneniyu. Klinicheskie i patogeneticheskie problemy narusheniya kletochnoi energetiki (mitokhondrial'naya patologiya). M 1999; 33-34.
  9. "Neonatologiya". Natsional'noe rukovodstvo. Pod red. akad. RAMN N.N. Volodina. M: GEOTAR-Media 2007; 848.
  10. Rogatkin S.O., Blinov D.V., Volodin N.N. i dr. Perspektivy primeneniya immunofermentnogo analiza neirospetsificheskikh antigenov v perinatal'noi nevrologii. Vopr gin akush i perinatol 2003; 2: 4: 8-13.
  11. Rogatkin S.O., Lyudkovskaya E.V., Volodin N.N. Lechenie detei, perenesshikh perinatal'nuyu gipoksiyu v periode rannei neonatal'noi adaptatsii. Vopr gin akush i perinatol 2005; 4: 3: 37-40.
  12. Rebrova O.Yu. Statisticheskii analiz meditsinskikh dannykh. Primenenie paketa prikladnykh programm Statistica. M: MediaSfera 2006; 312.
  13. Chekhonin V.P., Dmitrieva T.B., Zhirkov Yu.A. Immunokhimicheskii analiz neirospetsificheskikh antigenov. M: Meditsina 2000; 415.
  14. Avery B. Gordon, MacDonald G. Mhairi, Martha D. Mullett, Mary M. Seshia. Avery's Neonatology: Pathophysiology and management of the newborn (6-th edition). Lippincott Williams & Wilkins 2005; 1504.
  15. Blennow M., Savman K., Ilves P et al. Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants. Acta Paediat 2001; 90: 1171-1175.
  16. Ezgu F.S., Atalay Y., Gucuyener K. et al. Neuron-specific enolase levels and neuroimaging in asphyxed preterm end term newborns. Ankara, Turkey. J Child Neurol 2002; 17: 11: 824-829.
  17. Hawdon J.M., Ward Piatt M.P., Aynsley-Green A. Patterns of metabolic adaptation for preterm and term infants in the first neonatal week. Arch Dis Child 1992; 67: 357-365.
  18. Hirayama A., Okoshi Y., Hachiya Y. et al. Early immunohistochemical detection of axonal damage and glial activation in extremely immature brains with periventricular leukomalacia. Clin Neuropathol 2001; 20: 87-91.
  19. Johnston M.V., Trescher W.H., Ishida A. et al. Neurobiology of hypoxic-ischemic injury in the developing brain. Pediat Res 2001; 49: 735-741.
  20. Nagdyman N., Komen W., Ko H.K. et al. Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia. Pediat Res 2001; 49: 502-506.
  21. Perlman J.M. Neurology: neonatology questions and controversies. Consulting editor, Richard A. Polin. Saunders-Elsevier 2008; 225.
  22. Raju Tonse N.K., Ariagno R.L., Higgins R. et al. Research in Neonatology for the 21st Century: Executive Summary of the National Institute of Child Health and Human Development-American Academy of Pediatrics Workshop. Part I: Academic Issues. Pediatrics 2005; 115: 468-474.
  23. Verkhratsky A., Butt A. Glial neurobiology: a textbook. John Wiley & Sons Ltd. England 2007; 209.
  24. Volpe J.J. Neurology of the Newborn 5th ed. Philadelphia: Elsevier 2008; 1042.
  25. Vos P.E., Lamers K.J., Hendriks J.C. et al. Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury. Neurology 2004; 62: 8: 1303-1310.
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