The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Sorokina E.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Semenova Zh.B.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Granstrem O.K.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Karaseva O.V.

State budgetary healthcare facility «Research Institute of Emergency Pediatric Surgery and Traumatology», Moscow Health Department, Moscow, Russian Federation

Meshcheriakov S.V.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Reutov V.P.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Sushkevich G.N.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Pinelis V.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Roshal' L.M.

Nauchno-issledovatel'skiĭ institut neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

S100B protein and autoantibodies to S100B protein in diagnostics of brain damage in craniocerebral trauma in children

Authors:

Sorokina E.G., Semenova Zh.B., Granstrem O.K., Karaseva O.V., Meshcheriakov S.V., Reutov V.P., Sushkevich G.N., Pinelis V.G., Roshal' L.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(8): 30‑35

Read: 3823 times

Download PDF (RU)
Contact the author
Table of contents

S100B PROTEIN AND AUTOANTIBODIES TO S100B PROTEIN IN DIAGNOSTICS OF BRAIN DAMAGE IN CRANIOCEREBRAL TRAUMA IN CHILDREN
S100B PROTEIN AND AUTOANTIBODIES TO S100B PROTEIN IN DIAGNOSTICS OF BRAIN DAMAGE IN CRANIOCEREBRAL TRAUMA IN CHILDREN

To cite this article:

Sorokina EG, Semenova ZhB, Granstrem OK, et al. S100B protein and autoantibodies to S100B protein in diagnostics of brain damage in craniocerebral trauma in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(8):30‑35. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Reorganization of the corticospinal tract and thalamocortical projections in children with sequelae of severe traumatic brain injury. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):56-61
Effi­cacy of Reco­gnan in the therapy of neurological diso­rders after traumatic brain injury. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):41-45
Traumatic brain injury: cognitive, affe­ctive diso­rders, and post-traumatic atta­cks. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):29-35
Inte­rleukin-6, cortisol, and brain-derived neurotrophic factor as biomarkers of the seve­rity of traumatic brain injury and its complications in acute and long-term periods: resu­lts of a prospective study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):237-243
Risk factors of unfa­vorable outcome after deco­mpressive craniectomy in children with severe traumatic brain injury. Burdenko's Journal of Neurosurgery. 2025;(3):42-47
Biomarkers of acute cere­bral damage in complex diagnosis of sepsis-associated ence­phalopathy. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):6-13
Predictors of adve­rse outcomes after severe traumatic brain injury. Burdenko's Journal of Neurosurgery. 2025;(5):71-78
Model for predicting mortality in patients with traumatic brain injury. Russian Journal of Anesthesiology and Reanimatology. 2025;(5):66-73
Microscopic asse­ssment of cere­bral edema in fatal traumatic brain injury during the first hour of the post-traumatic period. Fore­nsic Medi­cal Expe­rtise. 2026;(1):26-29
Abstract:

Levels of antibodies AB (AB) to S100B and S100B protein were studied in the blood serum of children with different severity and outcomes of traumatic brain injury (TBI) from the 1st to 15-75th days after TBI. Severity and outcomes were assessed using the Glasgow Coma Scale (GCS). Patients were stratified by outcomes into the following groups: complete recovery (group 1), moderate disability (group 2), high disability (group 3), vegetative state (group 4) and fatal outcome (group 5). In patients of groups 1-3, the changes of S100B in the blood serum didn't depend on the severity of brain's damage; the significant increase of S100B protein levels in the 1st day was accompanied by the decrease to the normal range in the following 2-3 days. On the contrary, the levels of nAB in these groups increased starting from 3-5 days corresponding to the severity of brain's damage. The development of vegetative state was accompanied by low S100B and high AB to S100B levels in the blood serum. The maximal level of S100B protein and increased levels of AB were observed in patients with fatal outcome. In most patients with combined TBI, the levels of both parameters were higher compared to those with separate TBI.

Keywords:

traumatic brain injury
autoantibodies to S100B
protein S100B

Authors:

Sorokina E.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Semenova Zh.B.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Granstrem O.K.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Karaseva O.V.

State budgetary healthcare facility «Research Institute of Emergency Pediatric Surgery and Traumatology», Moscow Health Department, Moscow, Russian Federation

Meshcheriakov S.V.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Reutov V.P.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Sushkevich G.N.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Pinelis V.G.

NII neotlozhnoĭ detskoĭ khirurgii i travmatologii, Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Institut vyssheĭ nervnoĭ deiatel'nosti i neĭrofiziologii RAN, Moskva;
OOO "Gerofarm", Sankt-Peterburg

Roshal' L.M.

Nauchno-issledovatel'skiĭ institut neotlozhnoĭ detskoĭ khirurgii i travmatologii, Moskva

Close metadata

References:

  1. Bazarnaya N.A., Goryunova A.V., Sorokina E.G. i dr. Dinamika urovnya aAT k glutamatnym retseptoram podtipa AMRA (GluR1) i NMDA (NR2A) u detei s khronicheskoi posttravmaticheskoi golovnoi bol'yu posle legkoi cherepno-mozgovoi travmy. Zhurn nevrol i psikhiatr 2006;106:8:50-53.
  2. Belyaeva I.A. Neirospetsificheskie belki v krovi i likvore pri kleshchevykh neiroinfektsiyakh (kliniko-diagnosticheskie i prognosticheskie aspekty): Avtoref. dis. ... kand. med. nauk. M 1995;28.
  3. Galieva G.Yu., Poponnikova T.V., Fedoseeva I.F. Diagnosticheskoe i prognosticheskoe znachenie neironspetsifichecheskoi enolazy i belka S100 pri kleshchevykh neiroinfektsiyakh u detei. Byul sib med 2008;204-207 (prilozhenie 1).
  4. Gannushkina I.V. Immunologicheskie aspekty travmy i sosudistykh porazhenii golovnogo mozga. M: Meditsina 1974;200.
  5. Pinelis V.G., Sorokina E.G. Autoimmunnye mekhanizmy modulyatsii aktivnosti glutamatnykh retseptorov u detei s epilepsiei i cherepno-mozgovoi travmoi. Vestnik RAMN 2008;12:44-51.
  6. Skoromets T.A. Vtorichnaya ishemiya golovnogo mozga v ostrom periode cherepno-mozgovoi travmy: Avtoref. dis. ... d-ra med. nauk. St-Peterburg 2002;42.
  7. Skoromets A.A., Dambinova S.A., D'yakonov M.M. i dr. Biokhimicheskie markery v diagnostike ishemii golovnogo mozga. Mezhdunar nevrol zhurn (Ukraina) 2009;5:27:15-20.
  8. Sorokina E.G., Storozhevykh T.P., Senilova Ya.E. i dr. Deistvie antitel k AMRA (GluR1) retseptoram glutamata na neirony mozga v pervichnykh kul'turakh mozzhechka i gippokampa. Byul eksp biol 2006;7:59-62.
  9. Sorokina E.G., Semenova Zh.B., Bazarnaya N.V. i dr. Autoantitela k retseptoram glutamata i produkty metabolizma oksida azota v syvorotke krovi detei v ostrom periode cherepno-mozgovoi travmy. Zhurn nevrol i psikhiatr im. S.S. Korsakova 2008;208:3:67-72.
  10. Boulanger L.M. Immune proteins in brain development and synaptic plasticity. Neuron 2009;64:1:93-109.
  11. Dambinova S.A., Khounteev G.A., Izykenova G.A. et al.  Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Clin Chem 2003;49:10:1752-1762.
  12. De Boussard C.N., Karlstedt D., Edman G. et al. S100 and cognitive impairment after mild traumatic brain injury. J Rehabil Med 2005;37:53-57.
  13. Donato R. S100: a multigenic family of calcium-modulated proteins of EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001;33:637-668.
  14. Ellis E.F., Willoughby K.A., Sparks S.A., Chen T. S100B protein is released from rat neonatal neurons, astrocytes, and microglia by in vitro trauma and anti-S100 increases trauma-induced delayed neuronal injury and negates the protective effect of exogenous S100B on neurons. J. Neurochem 2007;101:1463-1470.
  15. Epstein O.I., Beregovoy N.A., Sorokina N.S. et al. . Membrane and synaptic effects of anti-S-100 are prevented by the same antibodies in low concentrations. Bioscience 2003;8:79-84.
  16. Hu J., Ferreira A., Van Eldik L. S100? induces neuronal cell death through nitric oxide release from astrocytes. J Neurochem 1997;69:2294-2301.
  17. Huerta P.T., Kowal C., DeGiorgio L.A. et al.  Immunology and behavior: Antibodies alter emotion. PNAS 2006;103:3:678-683.
  18. Kleindienst A., Ross B.M. A critical analysis of the role of the neurotrophic protein S100B in acute brain injury. J Neurotrauma 2006;23:1185-1200.
  19. Li Y., Wang J., Sheng J.C. et al. S100? increases levels of β-amyloid precursor protein and its encoding mRNA in rat neuronal cultures. J Neurochem 1998;71:1421-1428.
  20. Li Y., Barger S.W., liu L. et al.  S100? induction of the proinflammatory cytokine interleukin-6 in neurons. J Neurochem 2000;74:143-150.
  21. Mc Alister A.K., van der Water J. Breaking boundaries in neuronal-immune interactions. Neuron 2009;64:1:9-12.
  22. Muller K., Townend W., Biasca N. et al.  S100B serum level predicts computed tomography findings after minor head injury. J Trauma 2007;62:6:1452-1456.
  23. Netto C.B., Conte S., Leite M.C. et al. Serum S100B protein is increased in fasting rats. Arch Med Res 2006;37:683-686.
  24. Rothermundt M., Peters M., Prehn J.H.M., Arolt V. S100B in brain damage and neurodegeneration. Microscop Res Tech 2003;60:614-632.
  25. Sedaghat F., Notopoulos A. S100 protein family and its application in clinical practice. HIPPOKRATIA 2008;12:4:198-204.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.