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Kubarko A.I.

Kafedra normal'noĭ fiziologii Belorusskogo gosudarstvennogo meditsinskogo universiteta

Kubarko N.P.

9-ia gorodskaia klinicheskaia bol'nitsa, Minsk

Character of age-related changes of saccadic eye movements in patients with multiple sclerosis

Authors:

Kubarko A.I., Kubarko N.P.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4): 73‑78

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CHARACTER OF AGE-RELATED CHANGES OF SACCADIC EYE MOVEMENTS IN PATIENTS WITH MULTIPLE SCLEROSIS
CHARACTER OF AGE-RELATED CHANGES OF SACCADIC EYE MOVEMENTS IN PATIENTS WITH MULTIPLE SCLEROSIS

To cite this article:

Kubarko AI, Kubarko NP. Character of age-related changes of saccadic eye movements in patients with multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4):73‑78. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

On the basis of the analysis of electrooculografy traces of saccadic eye movements, the quantitative estimation of static and dynamic parameters of visual and auditory saccades, and аntisaccades in regard with age was carried out in 62 patients with multiple sclerosis and 163 healthy controls. The significant increase (p<0,05) of saccadic latency was observed in older controls compared to younger ones and in patients with multiple sclerosis compared to age-matched controls. The differences in saccadic latency, duration, accuracy, peak velocity and other parameters are discussed in the aspect of their association with processes of development, myelination and aging of visual and central nervous system.

Keywords:

saccades
eyes movements
age-related changes
visual system
myelination
demyelination
multiple sclerosis

Authors:

Kubarko A.I.

Kafedra normal'noĭ fiziologii Belorusskogo gosudarstvennogo meditsinskogo universiteta

Kubarko N.P.

9-ia gorodskaia klinicheskaia bol'nitsa, Minsk

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References:

  1. Gaikova O.N., Bisaga G.N., Onishchenko L.S., Chikurova A.A. Kharakteristika glial'nykh reaktsii pri rasseyannom skleroze. Neiroimmunologiya 2003; 1: 2: 35-36.
  2. Gnezditskii V.V. Vyzvannye potentsialy mozga v klinicheskoi praktike. M: MEDpress-inform 2003; 246.
  3. Ivanitskii A.M. Neirofiziologicheskie mekhanizmy vospriyatiya i pamyati: vyzvannye potentsialy. V kn.: Mekhanizmy deyatel'nosti mozga cheloveka. Chast' 1. Neirofiziologiya cheloveka. Pod red. N.P. Bekhtereva. L: Nauka 1988; 151-170.
  4. Kubarko A.I., Kolesnikova M.L., Kubarko N.P. Kharakter sakkadicheskikh dvizhenii glaz pri rasseyannom skleroze. Zdravookhranenie 2003; 1: 18-22.
  5. Kubarko Yu.A. Pokazateli bystrykh dvizhenii glaz u bol'nykh rasseyannym sklerozom. Zdravookhranenie 2006; 12: 4-8.
  6. Kubarko A.I., Kubarko N.P. Korrektsionnye glaznye sakkady u bol'nykh rasseyannym sklerozom. Zhurn nevrol i psikhiat 2008; 108: 6: 47-51.
  7. Nedz'ved' M.K., Nedz'ved' T.M. Morfologicheskaya diagnostika rasseyannogo skleroza. Med zhurn 2006; 4: 11-13.
  8. Mit'kin A.A. Sistemnaya organizatsiya zritel'nykh funktsii. M: Nauka 1988; 120.
  9. Shmidt T.E. Patogenez, lechenie i vedenie bol'nykh rasseyannym sklerozom. Nevrol zhurn 2003; 3: 46-49.
  10. Bartzokis G., Cummings J.L., Sultzer D. et al. White matter structural integrity in healthy aging adults and patients with Alzheimer disease. A magnetic resonance imaging study. Arch Neurol 2003; 60: 393-398.
  11. Boneschi F.M., Rovaris M., Comi G., Fillipi M. The use of magnetic resonance imaging in multiple sclerosis: lessons learned from clinical trials. Multiple Sclerosis 2004; 10: 341-347.
  12. Brodal P. The central nervous system. 2-nd Ed. Oxford 1998; 675.
  13. Comi G., Leocani L., Medaglini S. et al. Measuring evoked responses in multiple sclerosis. Multiple Sclerosis 1999; 5: 263-267.
  14. DeLuca G.C., Williams K., Evangelou N. et al. The contribution of demyelination to axonal loss in multiple sclerosis. Brain 2006;129: 1507-1516.
  15. Fields R.D., Stevens-Graham B. New insights into neuron-glia communication. Science 2002; 298: 556-562.
  16. Evangelou N., Konz D., Esiri M.M. et al. Size-selective neuronal changes in anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis. Brain 2001; 124:1813-1820.
  17. Fischer B., Weber H. Saccadic reaction times of dyslexic and age-matched normal subjects. Perception 1990; 19: 805-818.
  18. Fraser C., Klistorner A., Graham S. et al. Multifocal visual evoked potential latency analysis. Predicting progression to multiple sclerosis. Arch Neurol 2006; 63: 847-850.
  19. Frohman E.M., Frohman T.C., Zee D.S. et al. The neuroophthalmology of multiple sclerosis. Lancet Neurol 2005; 4: 111-121.
  20. Hickman S.J., Brierley C.M.H., Brex P.A. et al. Sontinuing optic nerve atrophy following optic neuritis: a serial MRI study. Multiple Sclerosis 2002; 8: 339-342.
  21. Hikosaka O., Takikawa Y., Kawagoe R. Role of the basal ganglia in the control of purposive saccadic eye movements. Physiological Rev 2000; 80: 3: 953-978.
  22. Irving E.L., Steinbach M.J., Lillakas L. et al. Horizontal saccade dynamics across the human life span. Invest Ophthalmol Visual Sci 2006; 47: 2478-2484.
  23. Kimmig H., Greenlee M.W., Gondan M. et al. Relationship between saccadic eye movements and cortical activity as measured by fMRI: quantitative and qualitative aspects. Exp Brain Res 2001; 141: 184-194.
  24. Leigh R.J., Kennard C. Using saccades as a research tool in the clinical neurosciences. Brain 2003; 7: 1-18.
  25. Melcangi R.C., Magnaghi V., Martini L. Aging in peripheral nerves: regulation of myelin protein genes by steroid hormones. Prog Neurobiol 2000; 60: 291-308.
  26. Mineo T., Zee D.S., Tamargo R.J. Effects of lesions of the oculomotor vermis on eye movements in primate: saccades. J Neurophysiol 1998; 80: 1911-1931.
  27. Morrison J.H., Hof P.R. Life and death of neurons in the aging brain. Science 1997; 278: 412-419.
  28. Munoz D.P., Broughton J.R., Goldring J.E., Armstrong I.T. Age-related performance of human subjects on saccadic eye movement tasks. Exp Brain Res 1998; 121: 391-400.
  29. Pakkenberg B., Pelvig D., Marner L. et al. Aging and the human neocortex. Exp Gerontol 2003; 38: 95-99.
  30. Peters A., Moss M.B., Sethares C. Effects of aging on myelinated nerve fibers in monkey primary visual cortex. J Comp Neurol 2000; 419: 74-76.
  31. Peters A. The effects of normal aging on myelin and nerve fibers: a review. J Neurocytol 2002; 31: 581-593.
  32. Peters A. Structural changes in the normally aging cerebral cortex of primates. Prog Brain Res 2002; 36: 455-465.
  33. Peters A., Sethares C. Is there remyelination during aging of the primate central nervous system? J Comp Neurol 2003; 460: 238-254.
  34. Pierrot-Deseilligny Ch., Milea D., Muri R.M. Eye movement control by the cerebral cortex. Current Opinion in Neurology 2004; 17: 17-25.
  35. Quaia Ch., Lefevre Ph., Optican L.M. Model of the control of saccades by superior colliculus and cerebellum. J Neurophysiol 1999; 82: 999-1018.
  36. Rocca M.A., Hicmann S.J., Bo L. et al. Imaging the optic nerve in multiple sclerosis. Multiple Sclerosis 2005; 11: 537-541.
  37. Sawabe Y., Matsumoto K., Goto N. et al. Morphometric nerve fiber analysis and aging process of the human abducent nerve. Okajimas Folia Anat Jpn 1998; 74: 337-343.
  38. Scheltens P., Barkhof F., Leys D. et al. Histopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal aging. Neurology 1995; 45: 883-888.
  39. Schik G., Mohr S., Hofferberth B. Effect of aging on saccadic eye movements to visual and auditory targets. Int Tinnitus 2000; 6: 154-159.
  40. Verdu E., Ceballos D., Vilches J.J., Navarro X. Influence of aging on peripheral nerve function and regeneration. J Peripher Nerv Syst 2000; 5: 191-208.
  41. Weinstock-Guttman B., Baier M., Stockton R. et al. Pattern reversal visual evoked potentials as a measure of visual pathway pathology in multiple sclerosis. Multiple sclerosis 2003; 9: 529-534.
  42. Wender M., Adamczewska-Goncerzewicz Z., Szczech J., Godlewski A. Myelin lipids in aging human brain. Neurochem Pathol 1988; 8: 121-130.
  43. Yang Q., Bucc M.P., Kapoula Z.E. The latency of saccades, vergence, and combined eye movements in children and in adult. Invest Ophthalmol Vis Sci 2002; 43: 2939-2949.
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