The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

Smolentseva I.G.

Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia;
Tsentr ékstrapiramidnykh zabolevaniĭ, Moskva

Ivanov A.K.

Natsional'nyĭ mediko-khirurgicheskiĭ tsentr im. N.I. Pirogova, Moskva

Non-motor fluctuations in Parkinson's disease

Authors:

Levin O.S., Smolentseva I.G., Ivanov A.K.

More about the authors

Read: 4488 times


To cite this article:

Levin OS, Smolentseva IG, Ivanov AK. Non-motor fluctuations in Parkinson's disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(3):90‑96. (In Russ.)

Recommended articles:
Diagnosis and treatment approaches for sialorrhea in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):29-34
Neurochemical mechanisms of tremor in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):64-72
Cognitive impairment in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):81-90
Bladder dysfunction in patients with stages I—III of Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):91-99
A portrait of a doctor with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):160-164
Pathomorphosis of the Parkinson’s disease against the background of DBS STN. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):21-27
Neuroinflammatory and neurodegenerative aspe­cts of Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):102-111

References:

  1. Golubev V.L., Levin Ya.I., Vein A.M. Bolezn' Parkinsona i sindrom parkinsonizma. M 1999; 416.
  2. Levin O.S. Razvitie motornykh flyuktuatsii u bol'nykh s razlichnymi stadiyami bolezni Parkinsona. Atmosfera. Nervnye bolezni 2005; 1: 10-16.
  3. Levin O.S. Sovremennye podkhody k diagnostike i lecheniyu flyuktuatsii pri bolezni Parkinsona. Zhurn nevrol i psikhiat 2006; 12: 74-80.
  4. Levin O.S., Fedorova N.V. Bolezn' Parkinsona. M 2006; 256.
  5. Levin O.S. Dekompensatsii pri bolezni Parkinsona. Nevrol zhurn 2007; 1: 8-15.
  6. Levin O.S., Smolentseva I.G. Nemotornye proyavleniya bolezni Parkinsona. M 2007; 19.
  7. Levin O.S., Smolentseva I.G. Osobennosti lecheniya bolezni Parkinsona v pozdnei stadii. Vrach 2007; 4: 12-16.
  8. Nodel' M.R., Yakhno N.N. Dvigatel'nye flyuktuatsii i diskinezii pri bolezni Parkinsona: novye vozmozhnosti terapii. Nevrol zhurn 2007; 2: 26-33.
  9. Shtok V.N., Fedorova N.V. Lechenie parkinsonizma. M 1997; 196.
  10. Yakhno N.N. Sovremennye podkhody k lekarstvennomu lecheniyu bolezni Parkinsona. Klin farmakol i ter 1994; 3-4: 92-97.
  11. Adler C.H. Relevance of motor complications in Parkinson's disease. Neurology 2002; 58: Suppl 1: 51-56.
  12. AhIskog J.E., Muenter M.D. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Dis 2001; 16: 448-158.
  13. Ashraf W., Wszolek Z.K., Pfeiffer R. et al. Anorectal function in fluctuating (on-off) Parkinson's disease. Mov Dis 1995; 10: 650-657.
  14. Baratti M., Calzetti S. Fluctuation of arterial blood pressure during end-of- dose akinesia in Parkinson's disease. J Neurol Neurosurg Psychiat 1984; 47: 1241-1243.
  15. Cantello R., Gilli M., Riccio A. et al. Mood changes associated with «end of dose deterioration» in Parkinson's disease. J Neurol Neurosurg Psychiat 1986; 49: l182-1190.
  16. Delis D., Direnfeld L., Alexander M.P. et al. Cognitive fluctuations associated with on-off phenomenon in Parkinson's disease. Neurology 1982; 32: 1049-1052.
  17. Djaldetti R., Baron J., Ziv I. et al. Gastric emptying in Parkinson's disease: patients with and without response fluctuations. Neurology 1996; 46: 2171-2175.
  18. Funkiewiez A., Ardouin A., Caputo E. et al. Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood and behavior in Parkinson's disease. J Neurol Neurosurg Psychiat 2004; 75: 834-839.
  19. Girotti E., Carella F., Grassi M.P. et al. Motor and cognitive performances of parkinsonian patients in the «on» and «off» phases of the disease. J Neurol Neurosurg Psychiat 1986; 49: 657-660.
  20. Gunal D.I.,Nurichalichi K., Tuncer N. et al. The clinical profile of non-motor fluctuations in Parkinson's disease patients. Can J Neurol Sci 2002; 29: 61-64.
  21. Hely M.A., Morris J.G., Reid W.G. et al. Sydney multicenter study of Parkinson's disesase. Mov Dis 2005; 20: 190-199.
  22. Hillen M.E., Sage J.I. Nonmotor fluctuations in patients with Parkinson's disease. Neurology 1996; 47: 1180-1183.
  23. Jankovic J., Nour F. Respiratory dyskinesia in Parkinson's disease. Neurology 1986; 36: 303-304.
  24. Maricle R.A., Nutt G.J., Valentine R.J. et al. Dose-response relationship of levodopa with mood and anxiety in fluctuating Parkinson's disease: a double-blind, placebo controlled study. Neurology 1995; 45: 1757-1760.
  25. Menza M.A., Sage J., Marshall E. et al. Mood changes and «on-off» phenomena in Parkinson's disease. Mov Dis 1990; 5: 148-151.
  26. Nissenbaum H., Quinn N.P., Brown R.G. et al. Mood swings associated with the «on-off» phenomenon in Parkinson's disease. Psychol Med 1987; 17: 899-904.
  27. Nutt J.G. Continuous dopaminergic stimulation: is it the answer to the motor complications of levodopa? Mov Dis 2007; 22: 1-9.
  28. Olanow C.W., Watts R.L., Koller W.C. An algorithm (decision tree) for the management of Parkinson's disease: treatment guidelines. Neurology 2001; 56: Suppl 5: 1-88.
  29. Pierantozzi M., Pietroiusti A., Brusa L. et al. Helicobacter pylori eradication and 1-dopa absorbtion in patients with PD and motor fluctuation. Neurology 2006; 66: 1824-1829.
  30. Pursiainen V., Haapaniemi T.N., Korpelainen J.T. et al. Sweating in Parkinsonian patients with wearing-off. Mov Dis 2007; 22: 828-832.
  31. Quinn N.P. Classification of fluctuations in patients with Parkinson's disease. Neurology 1988; 51: Suppl 2: 25-29.
  32. Racette B.A., Hartlein J.M., Hershey T. et al. Clinical features and comorbidity of mood fluctuations in Parkinson's disease. J Neuropsychiat Clin Neurosci 2002; 14: 438-442.
  33. Raudino F. Non motor off in Parkinson's disease. Acta Neurol Scand 2001; 104: 312-315.
  34. Richard I.H., Frank S., McDermott M.P. et al. The ups and downs of Parkinson's disease: prospective study of mood and anxiety fluctuations. Cogn Behav Neurol 2004; 17: 201-207.
  35. Sage J.I., Mark M.H. Drenching sweats as an «off» phenomenon in Parkinson's disease: treatment and relation to plasma levodopa profile. Ann Neurol 1995; 37: 120-122.
  36. Schrag A., Quinn N. Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study. Brain 2000; 123: 2297-2305.
  37. Stacy M., Bowron A., Guttman M. et al. Identification of motor and non-motor wearing - off in Parkinson's disease: comparison of a patient questionnaire versus a clinician assessment. Mov Dis 2005; 20:726-733.
  38. Vazquez A., Jimenez F.J., Garcia-Ruiz P. et al. Panic attacks in Parkinson's disease. Acta Neurol Scand 1993; 87: 14-18.
  39. Witjas T., Kaphan E., Azulay J.P. et al. Non-motor fluctuations in Parkinson's disease: frequent and disabling. Neurology 2002; 59: 408-413.
  40. Witjas T., Kaphan E., Reégis J. et al. Effects of chronic subthalamic stimulation on nonmotor fluctuations in Parkinson's disease. Mov Dis 2007; 22: 1729-1734.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.