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Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Panteleeva G.P.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Bologov P.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Abramova L.I.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Molecular-genetic approach to the clinical and nosologic differentiation of schizoaffective disorder

Authors:

Golimbet V.E., Panteleeva G.P., Bologov P.V., Korovaĭtseva G.I., Abramova L.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(10): 48‑52

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MOLECULAR-GENETIC APPROACH TO THE CLINICAL AND NOSOLOGIC DIFFERENTIATION OF SCHIZOAFFECTIVE DISORDER
MOLECULAR-GENETIC APPROACH TO THE CLINICAL AND NOSOLOGIC DIFFERENTIATION OF SCHIZOAFFECTIVE DISORDER

To cite this article:

Golimbet VE, Panteleeva GP, Bologov PV, Korovaĭtseva GI, Abramova LI. Molecular-genetic approach to the clinical and nosologic differentiation of schizoaffective disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(10):48‑52. (In Russ.)

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The aim of the study was to find molecular-genetic variants associated with nosologically independent schizoaffective disorder (SAD) which clinical presentations had been specified earlier. Authors studied a sample of 230 patients including 39 with "nuclear" (nosologically independent) and marginal (intermediate) variants of SAD, 53 with schizophrenia with schizoaffective states and 81 with schizophrenia with affective disorders in the structure of psychotic attacks. In these groups, authors studied the following polymorphisms: 5-HTTLPR, Val66Met BDNF, T102C 5-HTR2a and С677Т MTHFR. Frequencies of genotypes were compared to those in a sample of healthy controls (328 people). It has been shown that the "nuclear" variant has a genetic profile represented by a combination of genetic variants (SS*ValVal*TT*CC) that distinguishes this clinical entity from other groups and controls. The results may be used as an additional criteria for clinical and nosological differentiation of SAD from schizophrenia.

Keywords:

chizoaffective psychosis
schizophrenia
gene polymorphism
nosological differentiation

Authors:

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Panteleeva G.P.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Bologov P.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Abramova L.I.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

List of references:

  1. Golimbet V.E., Abramova L.I., Kaleda V.G. i dr.Molekulyarno-geneticheskie aspekty differentsiatsii shizoaffektivnogo psikhoza i pristupoobraznoi shizofrenii. Vestn RAMN 2007; 3: 3-7.
  2. Golimbet V.E., Lebedeva I.S., Alfimova M.V. i dr.Geny, svyazannye s metabolizmom gomotsisteina, i funktsiya vnimaniya u bol'nykh shizofreniei i shizoaffektivnym psikhozom. Zhurn nevrol i psikhiat 2010; 110: 6: 86-89.
  3. Panteleeva G.P., Bologov P.V.Kliniko-nozologicheskii podkhod k diagnostike shizoaffektivnogo psikhoza. Zhurn nevrol i psikhiat 2002; 102: 9: 4-8.
  4. Panteleeva G.P., Bologov P.V.Shizoaffektivnyi psikhoz: nozologicheskaya otsenka i differentsial'nyi diagnoz. Zhurn nevrol i psikhiat 2008; 108: 9: 4-10.
  5. Averill P.M., Reas D.L., Shack A. et al.Is schizoaffective disorder a stable diagnostic category: a retrospective examination. Psychiat Q 2004; 75: 3: 215-227.
  6. Benabarre A., Vieta E., Colom F. et al.Bipolar disorder, schizoaffective disorder and schizophrenia: epidemiologic, clinical and prognostic differences. Eur Psychiat 2001; 16: 3: 167-172.
  7. Brown A.S., Susser E.S.Homocysteine and schizophrenia: from prenatal to adult life. Prog Neuropsychopharmacol Biol Psychiat 2005; 29: 1175-1180.
  8. Golimbet V.E., Alfimova M.V., Manandyan K.K. et al.5HTR2A gene polymorphism and personality traits in patients with major psychoses. Eur Psychiat 2002; 17: 1: 24-28.
  9. Golimbet V., Korovaitseva G., Abramova L., Kaleda V.The 844ins68 polymorphism of the cystathionine beta-synthase gene is associated with schizophrenia. Psychiat Res 2009; 170: 2-3: 168-171.
  10. Lencz T., Lipsky R.H., DeRosse P. et al.Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes. Br J Psychiat 2009; 194: 4: 313-318.
  11. Lesch K.P., Bengel D., Heils A. et al.Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
  12. Marneros A.Schizoaffective disorder: clinical aspects, differential diagnosis, and treatment. Curr Psychiat Rep 2003; 5: 3: 202-205.
  13. Neves-Pereira M., Cheung J.K., Pasdar A. et al.BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiat 2005; 10: 2: 208-212.

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