The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Burd S.G.

Federal Center of Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University;
Scientific and Practical Center for Child Psychoneurology

Lebedeva A.V.

Federal Center of Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Rubleva Yu.V.

Federal Center of Brain Research and Neurotechnologies

Pantina N.V.

Federal Center of Brain Research and Neurotechnologies

Efimenko A.P.

Federal Center of Brain Research and Neurotechnologies

Kovaleva I.I.

Federal Center of Brain Research and Neurotechnologies

EEG changes in patients with Alzheimer’s disease

Authors:

Burd S.G., Lebedeva A.V., Rubleva Yu.V., Pantina N.V., Efimenko A.P., Kovaleva I.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2): 72‑76

DOI: 10.17116/jnevro202412404272

Read: 2459 times

Contact the author
Table of contents

EEG CHANGES IN PATIENTS WITH ALZHEIMER’S DISEASE
EEG CHANGES IN PATIENTS WITH ALZHEIMER’S DISEASE

To cite this article:

Burd SG, Lebedeva AV, Rubleva YuV, Pantina NV, Efimenko AP, Kovaleva II. EEG changes in patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4‑2):72‑76. (In Russ.)
https://doi.org/10.17116/jnevro202412404272

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
The pote­ntial of neurofeedback control in treating inso­mnia and improving sleep quality (a systematic review). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):57-63
Cyto­kine status of patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):5-12
The main mechanisms of deve­lopment of cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):13-18
Curcumin-induced increased reti­nal fluorescence as a new method in the early diagnosis of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):19-25
Differential diagnosis of Alzheimer’s disease and vascular cognitive diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):26-35
A comprehensive study of Alzheimer’s disease biomarkers in plasma and cere­brospinal fluid. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):43-53
Prospects for treating Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):54-60
Treatment features of patients with vascular cognitive impairments. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):69-76
Inve­stigation of the rela­tionship of indi­vidual characteristics of the brain bioelectrical acti­vity with levels of mental stress, aggression, anxiety, and depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):108-117
Novel prospects for early diagnosis of cognitive impairment using Eye-tracking technology. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):13-20
Abstract:

The prevalence of cognitive impairment is steadily increasing compared to previous years. According to the World Health Organization, the number of people living with dementia will increase reaching 82 million in 2030 and 152 million in 2050. The most common cause is Alzheimer’s disease (AD). The pathophysiological process in AD begins several years before the onset of clinical symptoms; so identifying it at an early stage would likely improve the clinical prognosis. The article presents EEG changes in patients with AD, and discusses the possibility of using EEG as a screening method for examining patients with cognitive impairment.

Keywords:

dementia
Alzheimer’s disease
EEG
spectral analysis
coherence

Authors:

Burd S.G.

Federal Center of Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University;
Scientific and Practical Center for Child Psychoneurology

Lebedeva A.V.

Federal Center of Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Rubleva Yu.V.

Federal Center of Brain Research and Neurotechnologies

Pantina N.V.

Federal Center of Brain Research and Neurotechnologies

Efimenko A.P.

Federal Center of Brain Research and Neurotechnologies

Kovaleva I.I.

Federal Center of Brain Research and Neurotechnologies

Received:

07.02.2024

Accepted:

13.02.2024

Close metadata

References:

  1. Hakim AM. A Proposed Hypothesis on Dementia: Inflammation, Small Vessel Disease, and Hypoperfusion Is the Sequence That Links All Harmful Lifestyles to Cognitive Impairment. Front Aging Neurosci. 2021;13:679837. https://doi.org/10.3389/fnagi.2021.679837
  2. Patterson C. World Alzheimer report 2018. The state of the art of dementia research: New frontiers. London: 2018. Alzheimer’s Disease International (ADI), London. Data Accessed 25.01.24  https://www.alzint.org/u/WorldAlzheimerReport2018.pdf
  3. Niu H, Álvarez-Álvarez I, Guillén-Grima F, et al. Prevalence and incidence of Alzheimer’s disease in Europe: A meta-analysis. Prevalencia e incidencia de la enfermedad de Alzheimer en Europa: metaanálisis. Neurologia. 2017;32(8):523-532.  https://doi.org/10.1016/j.nrl.2016.02.016
  4. Bogolepova AN, Vasenina EE, Gomzyakova NA, et al. Clinical Guidelines for Cognitive Disorders in Elderly and Older Patients. S.S. Korsakov Journal of Neurology and Psichiatry. 2021;121(10-3):6-137. (In Russ.). https://doi.org/10.17116/jnevro20211211036
  5. Vasenina EE, Levin OS, Sonin AG. Modern trends in epidemiology of dementia and management of patients with cognitive impairment. S.S. Korsakov Journal of Neurology and Psichiatry. 2017;117(6-2):87-95. (In Russ.). https://doi.org/10.17116/jnevro20171176287-95
  6. Babiloni C, Lizio R, Marzano N, et al. Brain neural synchronization and functional coupling in Alzheimer’s disease as revealed by resting state EEG rhythms. Int J Psychophysiol. 2016;103:88-102.  https://doi.org/10.1016/j.ijpsycho.2015.02.008
  7. Emelin AYu. New criteria for diagnosing Alzheimer’s disease. Neurology, Neuropsychiatry, Psychosomatics. 2011;3(4):5-8. (In Russ.). https://doi.org/10.14412/2074-2711-2011-337
  8. Koberskaya NN. Alzheimer’s disease: new diagnostic criteria and therapeutic aspects depending on the stage of the disease. Meditsinskiy sovet = Medical Council. 2017;(10):18-24. (In Russ.). https://doi.org/10.21518/2079-701X-2017-10-18-24
  9. Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270-279.  https://doi.org/10.1016/j.jalz.2011.03.008
  10. Scheltens P, Leys D, Barkhof F, et al. Atrophy of medial temporal lobes on MRI in «probable» Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992;55(10):967-972.  https://doi.org/10.1136/jnnp.55.10.967
  11. Aoki Y, Takahashi R, Suzuki Y, et al. EEG resting-state networks in Alzheimer’s disease associated with clinical symptoms. Sci Rep. 2023;13(1):3964. https://doi.org/10.1038/s41598-023-30075-3
  12. Wang WY, Yu JT, Liu Y, et al. Voxel-based meta-analysis of grey matter changes in Alzheimer’s disease. Transl Neurodegener. 2015;4:6-9.  https://doi.org/10.1186/s40035-015-0027-z
  13. Minoshima S. Imaging Alzheimer’s disease: clinical applications. Neuroimaging Clin N Am. 2003;13(4):769-780.  https://doi.org/10.1016/s1052-5149(03)00099-6
  14. Chandra A, Valkimadi PE, Pagano G, et al. Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer’s disease and mild cognitive impairment. Hum Brain Mapp. 2019;40(18):5424-5442. https://doi.org/10.1002/hbm.24782
  15. Uzuegbunam BC, Librizzi D, Hooshyar Yousefi B. PET Radiopharmaceuticals for Alzheimer’s Disease and Parkinson’s Disease Diagnosis, the Current and Future Landscape. Molecules. 2020;25(4):977.  https://doi.org/10.3390/molecules25040977
  16. Ding Y, Chu Y, Liu M, et al. Fully automated discrimination of Alzheimer’s disease using resting-state electroencephalography signals. Quant Imaging Med Surg. 2022;12(2):1063-1078. https://doi.org/10.21037/qims-21-430
  17. Keller SM, Reyneke C, Gschwandtner U, et al. Information Contained in EEG Allows Characterization of Cognitive Decline in Neurodegenerative Disorders. Clin EEG Neurosci. 2023;54(4):391-398.  https://doi.org/10.1177/15500594221120734
  18. Ivanov LB. Applied computer electroencephalography. M.: JSC «Antidor»; 2000. (In Russ.).
  19. Riekkinen P, Buzsaki G, Riekkinen P Jr, et al. The cholinergic system and EEG slow waves. Electroencephalogr Clin Neurophysiol. 1991;78(2):89-96.  https://doi.org/10.1016/0013-4694(91)90107-f
  20. Simfukwe C, Han SH, Jeong HT, et al. qEEG as Biomarker for Alzheimer’s Disease: Investigating Relative PSD Difference and Coherence Analysis. Neuropsychiatr Dis Treat. 2023;19:2423-2437. https://doi.org/10.2147/NDT.S433207
  21. Adamis D, Sahu S, Treloar A. The utility of EEG in dementia: a clinical perspective. Int J Geriatr Psychiatry. 2005;20(11):1038-1045. https://doi.org/10.1002/gps.1393
  22. Riekkinen P Jr, Sirviö J, Riekkinen M, et al. EEG changes induced by acute and chronic quisqualic or ibotenic acid nucleus basalis lesions are stabilized by tacridine. Brain Res. 1991;559(2):304-308.  https://doi.org/10.1016/0006-8993(91)90016-o
  23. Brassen S, Adler G. Short-term effects of acetylcholinesterase inhibitor treatment on EEG and memory performance in Alzheimer patients: an open, controlled trial. Pharmacopsychiatry. 2003;36(6):304-308.  https://doi.org/10.1055/s-2003-45118
  24. Onofrj M, Thomas A, Iacono D, et al. The effects of a cholinesterase inhibitor are prominent in patients with fluctuating cognition: a part 3 study of the main mechanism of cholinesterase inhibitors in dementia. Clin Neuropharmacol. 2003;26(5):239-251.  https://doi.org/10.1097/00002826-200309000-00008
  25. Adler G, Brassen S, Chwalek K, et al. Prediction of treatment response to rivastigmine in Alzheimer’s dementia. J Neurol Neurosurg Psychiatry. 2004;75(2):292-294. 
  26. Jelic V, Kowalski J. Evidence-based evaluation of diagnostic accuracy of resting EEG in dementia and mild cognitive impairment. Clin EEG Neurosci. 2009;40(2):129-142.  https://doi.org/10.1177/155005940904000211
  27. Melnikova TS, Storozhakova YaA, Lapin IA, et al. Characteristics of the EEG emotional memory in patients with first episode paranoid schizophrenia. Social and Clinical Psychiatry. 2010;4:39. (In Russ.).
  28. Pachou E, Vourkas M, Simos P, et al. Working memory in schizophrenia: an EEG study using power spectrum and coherence analysis to estimate cortical activation and network behavior. Brain Topogr. 2008;21:128-137. 
  29. Alfimova MV, Melnikova TS, Lapin IA. The use of coherent EEG analysis and reactivity to psychophysiological tests in the first episode of schizophrenia. S.S. Korsakov Journal of Neurology and Psichiatry. 2010;110(3):97-102. (In Russ.).
  30. Jelic V, Julin P, Shigeta M, et al. Apolipoprotein E epsilon4 allele decreases functional connectivity in Alzheimer’s disease as measured by EEG coherence. J Neurol Neurosurg Psychiatry. 1997;63(1):59-65.  https://doi.org/10.1136/jnnp.63.1.59
  31. Locatelli T, Cursi M, Liberati D, et al. EEG coherence in Alzheimer’s disease. Electroencephalogr Clin Neurophysiol. 1998;106(3):229-237.  https://doi.org/10.1016/s0013-4694(97)00129-6
  32. Wada Y, Nanbu Y, Koshino Y, et al. Reduced interhemispheric EEG coherence in Alzheimer disease: analysis during rest and photic stimulation. Alzheimer Dis Assoc Disord. 1998;12(3):175-181.  https://doi.org/10.1097/00002093-199809000-00009
  33. Knott V, Mohr E, Mahoney C, et al. Electroencephalographic coherence in Alzheimer’s disease: comparisons with a control group and population norms. J Geriatr Psychiatry Neurol. 2000;13(1):1-8.  https://doi.org/10.1177/089198870001300101
  34. Jelic V, Johansson SE, Almkvist O, et al. Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer’s disease. Neurobiol Aging. 2000;21(4):533-540.  https://doi.org/10.1016/s0197-4580(00)00153-6
  35. Brunovsky M, Matousek M, Edman A, et al. Objective assessment of the degree of dementia by means of EEG. Neuropsychobiology. 2003;48(1):19-26.  https://doi.org/10.1159/000071824
  36. Babiloni C, Frisoni GB, Vecchio F, et al. Global functional coupling of resting EEG rhythms is related to white-matter lesions along the cholinergic tracts in subjects with amnesic mild cognitive impairment. J Alzheimers Dis. 2010;19(3):859-871. 
  37. Gallego-Jutglà E, Elgendi M, Vialatte F, et al. Diagnosis of Alzheimer’s disease from EEG by means of synchrony measures in optimized frequency bands. Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:4266-4270. https://doi.org/10.1109/EMBC.2012.6346909
  38. Babiloni C, Frisoni G, Vecchio F, et al. Global functional coupling of resting EEG rhythms is abnormal in mild cognitive impairment and Alzheimer’s disease: A multicenter EEG study. J Psychophysiol. 2009;23(4):224-234.  https://doi.org/10.1027/0269-8803.23.4.224
  39. Adler G, Brassen S, Jajcevic A. EEG coherence in Alzheimer’s dementia. J Neural Transm (Vienna). 2003;110(9):1051-1058. https://doi.org/10.1007/s00702-003-0024-8
  40. Aoki Y, Ishii R, Pascual-Marqui RD, et al. Detection of EEG-resting state independent networks by eLORETA-ICA method. Front Hum Neurosci. 2015;9:31.  https://doi.org/10.3389/fnhum.2015.00031
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.