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Chritinin D.F.

Sechenov First Moscow State Medical University (Sechenov University)

Shamrey V.K.

Kirov Military Medical Academy

Litvinenko I.V.

Kirov Military Medical Academy

Kurasov E.S.

Kirov Military Medical Academy

Tsygan N.V.

Kirov Military Medical Academy;
Konstantinov Peterburg Institute of Nuclear Physics of the National Research Center «Kurchatov Institute»

Vainshenker Yu.I.

Institute of Experimental Medicine

Psychological, psychiatric and neurological aspects of COVID-19

Authors:

Chritinin D.F., Shamrey V.K., Litvinenko I.V., Kurasov E.S., Tsygan N.V., Vainshenker Yu.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(4‑2): 44‑51

DOI: 10.17116/jnevro202312304244

Read: 2938 times

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Table of contents

PSYCHOLOGICAL, PSYCHIATRIC AND NEUROLOGICAL ASPECTS OF COVID-19
PSYCHOLOGICAL, PSYCHIATRIC AND NEUROLOGICAL ASPECTS OF COVID-19

To cite this article:

Chritinin DF, Shamrey VK, Litvinenko IV, Kurasov ES, Tsygan NV, Vainshenker YuI. Psychological, psychiatric and neurological aspects of COVID-19. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(4‑2):44‑51. (In Russ.)
https://doi.org/10.17116/jnevro202312304244

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

OBJECTIVE

To analyze neurological, psychological and psychiatric aspects of COVID-19, as well as to study the current state of the problem.

MATERIAL AND METHODS

The study included 103 patients with COVID-19. The main research method was clinical/psychopathological. To study the impact of activities related to the care of patients with COVID-19 in a hospital setting, the medical and psychological state of 197 hospital workers involved in the treatment of patients with COVID-19 was assessed. The level of anxiety distress was assessed with the Psychological Stress Scale (PSM-25), distress indicators corresponded to values of more than 100 points. The severity of anxiety and depressive symptoms was assessed using the Hospital Anxiety and Depression Scale (HADS).

RESULTS

When considering psychopathological disorders in the context of COVID-19, it is necessary to distinguish between two main groups of disorders: mental disorders during the pandemic, and mental disorders directly caused by the causative agent SARS-CoV-2. The analysis of psychological and psychiatric aspects in various periods of the initial stage of COVID-19 showed that each of them was characterized by specific features depending on the nature of the influence of different pathogenic factors. In the structure of nosogenic mental disorders in patients with COVID-19 (103 patients), the following clinical forms were identified: acute reaction to stress (9.7%), anxiety-phobic disorders (41.7%), depressive symptoms (28.1%), hyponosognosic nosogenic reactions (20.5%). At the same time, the majority of the patients had manifestations of somatogenic asthenia (93.2%). A comparative analysis of neurological and psychological/psychiatric aspects of COVID-19 showed that the main mechanisms of the impact of highly contagious coronaviruses, including the SARS-CoV-2, on the central nervous system are: cerebral thrombosis and cerebral thromboembolism, damage to the neurovascular unit, neurodegeneration, including that induced by cytokines, and immune-mediated demyelinating nerve damage.

CONCLUSION

Neurological and psychological/psychiatric aspects of COVID-19 should be taken into account both at the stage of disease treatment and in the post-infection period due to the pronounced neurotropism of SARS-CoV-2 and its effect on the neurovascular unit. Along with helping patients, an important aspect is the preservation of the mental health of medical personnel working in hospitals for infectious diseases, due to special working conditions and a high level of professional stress.

Keywords:

COVID-19
neurological disorders
neurovascular unit
mental disorders

Authors:

Chritinin D.F.

Sechenov First Moscow State Medical University (Sechenov University)

Shamrey V.K.

Kirov Military Medical Academy

Litvinenko I.V.

Kirov Military Medical Academy

Kurasov E.S.

Kirov Military Medical Academy

Tsygan N.V.

Kirov Military Medical Academy;
Konstantinov Peterburg Institute of Nuclear Physics of the National Research Center «Kurchatov Institute»

Vainshenker Yu.I.

Institute of Experimental Medicine

Received:

20.10.2022

Accepted:

15.12.2022

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