Family history of mood disorders may weaken the link between adverse childhood experience and suicidality in patients with depression

Kibitov A.A.; Kasyanov E.D.; Nikolishin A.E.; Rukavishnikov G.V.; Malyshko L.V.; Popovich U.O.; Golimbet V.E.; Neznanov N.G.; Shmukler A.B.; Kibitov A.O.; Mazo G.E.

doi:https://doi.org/10.17116/jnevro202212206256

Kibitov A.A.

Centre for Mental Health Research

ORCID: 0000-0001-7766-9675

Kasyanov E.D.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-4658-2195

Nikolishin A.E.

Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0002-6871-1234

Rukavishnikov G.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-5282-2036

Malyshko L.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-5470-4359

Popovich U.O.

Mental Health Research Center

Golimbet V.E.

Mental Health Research Center

ORCID: 0000-0002-9960-7114

Neznanov N.G.

Bekhterev National Medical Research Center for Psychiatry and Neurology;
Pavlov First Saint-Petersburg State Medical University

ORCID: 0000-0001-5618-4206

Shmukler A.B.

Serbsky National Medical Research Center of Psychiatry and Narcology

Kibitov A.O.

Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0002-8771-625X

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0001-7910-9129

Family history of mood disorders may weaken the link between adverse childhood experience and suicidality in patients with depression

Authors:

Kibitov A.A., Kasyanov E.D., Nikolishin A.E., Rukavishnikov G.V., Malyshko L.V., Popovich U.O., Golimbet V.E., Neznanov N.G., Shmukler A.B., Kibitov A.O., Mazo G.E.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(6‑2): 56‑63

DOI: 10.17116/jnevro202212206256

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To cite this article:

Kibitov AA, Kasyanov ED, Nikolishin AE, et al. . Family history of mood disorders may weaken the link between adverse childhood experience and suicidality in patients with depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(6‑2):56‑63. (In Russ.)
https://doi.org/10.17116/jnevro202212206256

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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OBJECTIVE

To study the impact of family history of mood disorders (FHMD), comprising genetic factors associated with depression, on the association between adverse childhood experience (ACE) and suicidality in depression.

MATERIAL AND METHODS

This multicenter cross-sectional study included 200 in- and outpatients (64% (n=128) women, mean age — (M (SD)) 36.21 (15.09) yrs.) with depression. Self-reports about FHMD and lifetime suicide attempts were obtained in clinical interview. The lifetime intensity of suicidal ideas and behavior was assessed by the Columbia-Suicide Severity Rating Scale (C-SSRS), ACE — by the Adverse Childhood Experience International Questionnaire (ACE-IQ).

RESULTS

FHMD did not affect the prevalence of ACE, suicide attempts and C-SSRS scores. We found that FHMD weakens the link between ACE and the risk of suicide attempt. The emotional neglect itself increased the risk of suicide attempt (p=0.001, OR=4.428, CI 95% [1.797—10.911]), but reduced it in patients with FHMD (p=0.03, OR=0.128, CI 95% [0.018—0.893]). GLM analysis revealed that FHMD significantly affected the association between suicidal ideas and domestic violence (p=0.045) and between suicidal behavior and emotional neglect (p=0.015) and abuse (p=0.044).

CONCLUSION

FHMD may weaken the link between ACE and suicidality in patients with depression. Suicidality in these patients may be underlined by mechanisms not involved in the response to ACE although more studies are needed.

Keywords:

depression

family history

suicide

Authors:

Kibitov A.A.

Centre for Mental Health Research

ORCID: 0000-0001-7766-9675

Kasyanov E.D.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-4658-2195

Nikolishin A.E.

Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0002-6871-1234

Rukavishnikov G.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-5282-2036

Malyshko L.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-5470-4359

Popovich U.O.

Mental Health Research Center

Golimbet V.E.

Mental Health Research Center

ORCID: 0000-0002-9960-7114

Neznanov N.G.

Bekhterev National Medical Research Center for Psychiatry and Neurology;
Pavlov First Saint-Petersburg State Medical University

ORCID: 0000-0001-5618-4206

Shmukler A.B.

Serbsky National Medical Research Center of Psychiatry and Narcology

Kibitov A.O.

Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0002-8771-625X

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0001-7910-9129

Received:

02.02.2022

Accepted:

22.03.2022

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