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Rubakova A.A.

Federal Center for Cerebrovascular Pathology and Stroke

Lebedeva D.I.

Tyumen State Medical University

Turovina E.F.

Tyumen State Medical University

Sun Cher I

Interregional Public Charity Fund for Relatives of Stroke Patients, Moscow, Russia, 125009

Khasanova L.T.

City Clinical Hospital No. 31

Suvorov A.Yu.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kazakova Z.D.

Pirogov Russian National Research Medical University

Clinical and pathophysiological features of stroke in patients with COVID-19

Authors:

Rubakova A.A., Lebedeva D.I., Turovina E.F., Sun Cher I, Khasanova L.T., Suvorov A.Yu., Kazakova Z.D.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12‑2): 26‑32

DOI: 10.17116/jnevro202212212226

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To cite this article:

Rubakova AA, Lebedeva DI, Turovina EF, Sun Cher I, Khasanova LT, Suvorov AYu, Kazakova ZD. Clinical and pathophysiological features of stroke in patients with COVID-19. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12‑2):26‑32. (In Russ.)
https://doi.org/10.17116/jnevro202212212226

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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OBJECTIVE

To study of modern literature on the clinical and pathophysiological features of stroke in patients with a new coronavirus infection (COVID-19).

MATERIAL AND METHODS

Published data were searched in the electronic databases Medline (PubMed) and eLIBRARY for the period 2019—2022.

RESULTS

It has been shown that patients with COVID-19 have a large number of risk factors for stroke, which may indicate that COVID-19 is a trigger for the development of the disease. Stroke predominantly occurs in 10—14 days after the onset of COVID-19, i.e. there was a delayed manifestation. Patients with stroke due to a COVID-19 are characterized by occlusion of large vessels or vessels, in which occlusion occurs extremely rarely, as well as the presence of several lesions. Specific laboratory signs are coagulopathy, the presence of antiphospholipid antibodies, as well as impaired liver and kidney function. This cohort of patients is characterized by high mortality and poor functional outcome (in more than 70% of cases). The pathogenetic mechanism underlying stroke has not been established yet, however, in patients with COVID-19, the activation of a cascade of blood coagulation and thrombosis reactions is recorded. Suppression of ACE2 due to the affinity of its receptors for the COVID-19 virus probably also plays a role in the pathogenesis of stroke, since when the virus enters the body, an imbalance of the renin-angiotensin system develops.

CONCLUSION

COVID-19 can lead to the development of various neurological diseases, including stroke. Further researches are needed to study neuropathogenesis of COVID-19 and the impact of virus SARS-CoV-2 on disease progression.

Keywords:

new coronavirus infection
COVID-19
stroke
ischemic stroke
hemorrhagic stroke
outcome
pathogenesis
review

Authors:

Rubakova A.A.

Federal Center for Cerebrovascular Pathology and Stroke

Lebedeva D.I.

Tyumen State Medical University

Turovina E.F.

Tyumen State Medical University

Sun Cher I

Interregional Public Charity Fund for Relatives of Stroke Patients, Moscow, Russia, 125009

Khasanova L.T.

City Clinical Hospital No. 31

Suvorov A.Yu.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kazakova Z.D.

Pirogov Russian National Research Medical University

Received:

06.06.2022

Accepted:

07.06.2022

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