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Spirina N.N.

Yaroslavl State Medical University

Spirin N.N.

Yaroslavl State Medical University

Kiseleva E.V.

Yaroslavl State Medical University

Dubchenco E.A.

Federal Center of Brain and Neurotechnologies

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Homocysteine and markers of endothelial dysfunction in multiple sclerosis

Authors:

Spirina N.N., Spirin N.N., Kiseleva E.V., Dubchenco E.A., Boyko A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7‑2): 90‑93

DOI: 10.17116/jnevro202112107290

Read: 2503 times

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Table of contents

HOMOCYSTEINE AND MARKERS OF ENDOTHELIAL DYSFUNCTION IN MULTIPLE SCLEROSIS
HOMOCYSTEINE AND MARKERS OF ENDOTHELIAL DYSFUNCTION IN MULTIPLE SCLEROSIS

To cite this article:

Spirina NN, Spirin NN, Kiseleva EV, Dubchenco EA, Boyko AN. Homocysteine and markers of endothelial dysfunction in multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7‑2):90‑93. (In Russ.)
https://doi.org/10.17116/jnevro202112107290

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To identify hyperhomocysteinemia and to assess its possible association with the course and other markers of endothelial damage in multiple sclerosis.

MATERIAL AND METHODS

Analysis of blood serum for homocysteine, for the content of adhesion molecules sPECAM-1, matrix metalloproteinase 9, blood plasma test for von Willebrand factor antigen in patients with multiple sclerosis. The values of these indicators were analyzed depending on the course and activity of the demyelinating process, the severity of neurological disorders, as also depending on the therapy received.

RESULTS

Hyperhomocysteinemia was found in more than half of patients with multiple sclerosis. A significantly higher homocysteine level was found in male patients, and hyperhomocysteinemia was associated with the activity of the process in patients with highly active multiple sclerosis.

CONCLUSION

The results of the study suggest a possible association of hyperhomocysteinemia with high process activity and disease progression, as well as with mechanisms of neurodegeneration. Determination of homocysteine concentration may be one potential marker for predicting the course of the disease.

Keywords:

multiple sclerosis
endothelial dysfunction
adhesion molecules
homocysteine
biomarkers

Authors:

Spirina N.N.

Yaroslavl State Medical University

Spirin N.N.

Yaroslavl State Medical University

Kiseleva E.V.

Yaroslavl State Medical University

Dubchenco E.A.

Federal Center of Brain and Neurotechnologies

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Received:

18.05.2021

Accepted:

19.05.2021

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References:

  1. Lyros E, Bakogiannis C, Liu Y, Fassbender K. Molecular links between endothelial dysfunction and neurodegeneration in Alzheimer’s disease. Curr Alzheimer Res. 2014;11(1):18-26.  https://doi.org/10.2174/1567205010666131119235254
  2. Gimbrone MA Jr, Garcia-Cardena G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res. 2016;118(4):620-636.  https://doi.org/10.1161/CIRCRESAHA.115.306301
  3. Canella B, Raine CS. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol. 1995;37:424-435.  https://doi.org/10.1002/ana.410370404
  4. De Vries HE, Kuiper J, de Boer AG, et al. The bloodbrain barrier in neuroinflammatory diseases. Pharmacol Rev. 1997;49:143-155. 
  5. Minagar A, Alexander JS. Blood-brain barrier disruption in multiple sclerosis. Mult Scler. 2003;9:6:540-549.  https://doi.org/10.1191/1352458503ms965oa
  6. Minagar A, Ostanin D, Long AC, et al. Serum from patients with multiple sclerosis downregulates occluding and VE-cadherin expression in cultured endothelial cells. Mult Scler. 2003;9:235-238.  https://doi.org/10.1191/1352458503ms916oa
  7. Lee BPL, Imhof BA. Lymphocyte transmigration in the brain: a new way of thinking. Nature Immunol. 2008;9:117-118.  https://doi.org/10.1038/ni0208-117
  8. Ortiz GG, Pacheco-Moises FP, Macias-Islas MA, et al. Role of the blood-brain barrier inmultiple sclerosis. Arch Med Res. 2014;45(8):687-697.  https://doi.org/10.1016/j.arcmed.2014.11.013
  9. D’haeseleer M, Cambron M, Vanopdenbosch L, De Keyser J. Vascular aspectsof multiple sclerosis. Lancet Neurol. 2011;10(7):657-666.  https://doi.org/10.1016/s1474-4422(11)70105-3
  10. Spirin NN, Spirina NN, Boyko AN. Von Willebrand factor and adhesion molecules in patients with multiple sclerosis. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2014;114:2(2):35-39. (In Russ.).
  11. Ansari R, Mahta A, Mallack E, Luo JJ. Hyperhomocysteinemia and neurological disorders: a review. J Clin Neurol. 2014;10(4):281-288.  https://doi.org/10.3988/jcn.2014.10.4.281
  12. Kang SS, Wong PW, Malinow MR. Hyperhomocysteinemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 1992;12:279-298.  https://doi.org/10.1146/annurev.nu.12.070192.001431
  13. Klerk M, Verhoef P, Clarke R, et al. MTHFR Studies Collaboration Group. MTHFR 677C->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002;288(16):2023-2031. https://doi.org/10.1001/jama.288.16.2023
  14. Fedin AI, Kaluga AS, Mironova OP, Solov’eva EYu. The role of homocysteine levels in the pathogenesis of cognitive disorders in patients with chronic cerebral ischemia. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2009;109:12(suppl 2):8-12.(In Russ.).
  15. Dubchenko EA, Ivanov AV, Boyko AN, et al. Hyperhomocysteinemia and endothelial dysfunction in vascular and autoimmune brain diseases. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2019;119(11):133-138.(In Russ.). https://doi.org/10.17116/jnevro2019119111127
  16. Moghaddasi M, Mamarabadi M, Mohebi N, et al. Homocysteine, vitamin B12 and folate levels in Iranian patients with multiple sclerosis: a case control study. Clin Neurol Neurosur. 2013;115:1802-1805. https://doi.org/10.1016/j.clineuro.2013.05.007
  17. Zoccolella S, Tortorella C, Iaffaldano P, et al. Elevated plasma homocysteine levels in patients with multiple sclerosis are associated with male gender. J Neurol. 2012;259(10):2105-2110. https://doi.org/10.1007/s00415-012-6464-z
  18. Ramsaransing GSM, Fokkema M R, Teelken A, et al. Plasma homocysteine levels in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2006;77(2):189-192.  https://doi.org/10.1136/jnnp.2005.072199
  19. Besler HT, Comoğlu S. Lipoprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis. Nutr Neurosci. 2003;6(3):189-196.  https://doi.org/10.1080/1028415031000115945
  20. Salemi G, Gueli MC, Vitale F, et al. Blood lipids, homocysteine, stress factors and vitamins in clinically stable multiple sclerosis patients. Lipids Health Dis. 2010;9:19.  https://doi.org/10.1186/1476-511X-9-19
  21. Oliveira SR, Flauzino T, Sabino BS, et al. Elevated plasma homocysteine levels are associated with disability progression in patients with multiple sclerosis. Metab Brain Dis. 2018;33(5):1393-1399. https://doi.org/10.1007/s11011-018-0224-4
  22. Lentz SR, Haynes WG. Homocysteine: is it a clinically important cardiovascular risk factor? Cleve Clin J Med. 2004;71(9):729-734. 
  23. Nygard O, Nordrehaug JE, Refsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337(4):230-236.  https://doi.org/10.1056/NEJM199707243370403
  24. Dayal S, Lentz SR. Role of Redox Reactions in the Vascular Phenotype of Hyperhomocysteinemic Animals. Antioxid Redox Signal. 2007;18:189-195.  https://doi.org/10.1089/ars.2007.1806
  25. Ho PI, Ortiz D, Rogers E, Shea TB. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J Neurosci Res. 2002;70:694-702.  https://doi.org/10.1002/jnr.10416
  26. Faraci FM, Lentz SR. Hiperhomocysteinemia, oxidative stress and cerebral vascular dysfunction. Stroke. 2004;35:345-347.  https://doi.org/10.1161/01.STR.0000115161.10646.67
  27. Skovierová H, Mahmood S, Blahovcová E, Hatok J, Lehotský J, Murín R. Effect of homocysteine on survival of human glial cells. Physiol Res. 2015;64:747-754.  https://doi.org/10.33549/physiolres.932897
  28. Spirina NN, Spirin NN, Boyko AN. Pathogenetic mechanisms of the negative impact of smoking in MS. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2015;115(8-2):85.(In Russ.).
  29. Sparacia G, Agnello F, Gambino A, et al. Multiple sclerosis: High prevalence of the ‘central vein’ sign in white matter lesions on susceptibility-weighted images. Neuroradiol J. 2018;31(4):356-361.  https://doi.org/10.1177/1971400918763577
  30. Teunissen CE, Killestein J, Kragt JJ, et al. Serum homocysteine levels in relation to clinical progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008;79:1349-1353. https://doi.org/10.1136/jnnp.2008.151555
  31. Fahmy EM, Elfayoumy NM, Abdelalim AM, et al. Relation of serum levels of homocysteine, vitamin B12 and folate to cognitive functions in multiple sclerosis patients. Int J Neurosci. 2018;128(9):835-841.  https://doi.org/10.1080/00207454.2018.1435538
  32. Nozari E, Ghavamzadeh S, Razazian N. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis. Clin Nutr Res. 2019;8(1):36-45.  https://doi.org/10.7762/cnr.2019.8.1.36
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