Correlation between endothelial dysfunction and sensorineural hearing loss

Noskova V.V.; Khrabrikov A.N.

doi:https://doi.org/10.17116/otorino20259003113

Noskova V.V.

Kirov State Medical University

ORCID: 0009-0006-3544-3508

Khrabrikov A.N.

Kirov State Medical University

ORCID: 0000-0003-1662-1568

Correlation between endothelial dysfunction and sensorineural hearing loss

Authors:

Noskova V.V., Khrabrikov A.N.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2025;90(3): 13‑18

DOI: 10.17116/otorino20259003113

Read: 591 times

Contact the author

Table of contents

To cite this article:

Noskova VV, Khrabrikov AN. Correlation between endothelial dysfunction and sensorineural hearing loss. Russian Bulletin of Otorhinolaryngology. 2025;90(3):13‑18. (In Russ.)
https://doi.org/10.17116/otorino20259003113

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)

Использование инфографики авторами научных работ

OBJECTIVE

To investigate the characteristics of blood markers of endothelial dysfunction (ED) in patients with sensorineural hearing loss (SNHL) and in normally hearing people, to evaluate the correlation of the data obtained with SNHL degree based on the results of tonal threshold audiometry in the studied groups.

MATERIAL AND METHODS

Auditory function was studied in 94 people, including patients with chronic CHT (n=32), patients with acute CHT (n=32), and normally hearing subjects (n=30). Hearing assessment was carried out by recording tonal threshold audiometry, laboratory parameters were assessed by enzyme immunoassay (ELISA) and the biochemical method. Statistical processing was carried out using the Microsoft Excel 13 software package.

RESULTS

The study of biomarkers of endothelial dysfunction revealed that SNHL is characterized by impaired motor and adhesive function of vascular endothelium. Acute SNHL is more often characterized by an increase in the blood serum of the marker of vasospasm, endothelin-1 (ET-1), with the highest values (more than 0.5 pg/ml) detected in grade I and III hearing loss. On the contrary, chronic SNHL is characterized by an increase in blood serum markers of vascular endothelial adhesion disorders, namely fibrinogen and vascular endothelial adhesion molecules-1 (VCAM-1). Moreover, the highest values (more than 60 ng/ml) of the latter are found in grade II and III chronic SNHL.

Keywords:

sensorineural hearing loss

endothelial dysfunction

pure tone threshold audiometry

Authors:

Noskova V.V.

Kirov State Medical University

ORCID: 0009-0006-3544-3508

Khrabrikov A.N.

Kirov State Medical University

ORCID: 0000-0003-1662-1568

Received:

15.01.2025

Accepted:

12.03.2025

Close metadata

References:

Hrabrikov AN. Monitoring of the state of the auditory periphery and the possibility of preclinical diagnosis of sensorineural hearing loss. Vyatskij meditsinskij vestnik. 2008;2:122-126. (In Russ.).
Kosyakov SYa, Kirdeeva AI. Etiopathogenetic aspects of idiopathic sensorineural hearing loss. Russian Bulletin of Otorhinolaryngology. 2017;82(2):95-101. (In Russ.). https://doi.org/10.17116/otorino201681695-101
Abdulkerimov KhT, Kartashova KI. Sostoyanie svertyvayushchej sistemy krovi u patsientov s sensonevral’noj tugoukhost’yu. Materialy XVIII s”ezda otorinolaringologov Rossii. SPb; 2011;2:3-7. (In Russ.).
Belicheva EG. Standards for the diagnosis of acute and sudden sensorineural hearing loss. Rossijskaya otorinolaringologiya. Prilozhenie. 2007:609-613. (In Russ.).
Gaevoy VP. Funktsional’noe sostoyanie nervnoj sistemy i vertebral’no-bazilyarnogo bassejna pri sensonevral’noj tugoukhosti s tochki zreniya klinitsista. Materialy XVII s”ezda otorinolaringologov Rossii. SPb: RIA-AMI; 2006:10-11. (In Russ.).
Levina MA. Etiopathogenetic aspects of sensorineural hearing loss. Russian Bulletin of Otorhinolaryngology. 2015;80(6):77-81. (In Russ.). https://doi.org/10.17116/otorino201580677-81
Savel’eva EE. Clinical features of the diagnosis of sensorineural hearing loss and deafness in children. Russian Bulletin of Otorhinolaryngology. 2014;(2):66-72. (In Russ.).
Quaranta N, Ramunni A, De Luca C, Brescia P, Dambra P, De Tullio G, Vacca A, Quaranta A. Endothelial progenitor cells in sudden sensorineural hearing loss. Acta Otolaryngologica. 2011;131(4):347-350. https://doi.org/10.3109/00016489.2010.536990
Kanzaki S, Sakagami M, Hosoi H, Murakami S, Ogawa K. High Fibrinogen in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss. PLoS One. 2014;9(8):e104680. https://doi.org/10.1371/journal.pone.0104680
Rinaldi M, Cavallaro G, Cariello M, Scialpi N, Quaranta N. Metabolic syndrome and idiopathic sudden sensori-neural hearing loss. PLoS One. 2020;15(8): e0238351. https://doi.org/10.1371/journal.pone.0238351
Noskova VV, Khrabrikov AN. Endothelial dysfunction as a pathogenetic factor of sensorineural hearing loss. Russian Bulletin of Otorhinolaryngology. 2024;89(1):21-27. (In Russ.). https://doi.org/10.17116/otorino20248901121
Naumova OV, Kudaeva IV, Masnavieva LB, D’yakovich OA. Role of intercellular adhesion molecules and antibodies to oxidized LDL in pathogenesis of cardiovascular diseases under mercury exposure. Gigiena i sanitariya. 2020;99(10):1120-1126. (In Russ.). https://doi.org/10.47470/0016-9900-2020-99-10-1120-1126
Antonova TV, Romanova MA, Lymar’ YuV. Endothelial dysfunction markers (VCAM-1, vWF) in chronic hepatitis C. Terapevticheskij arkhiv. 2013;85(12):86-89. (In Russ.).
Bayandurova KM, Batyushin MM, Sarvilina IV, Antipova NV, Sinel’nik EV. Assessment of the relationship between blood vcam-1 levels and clinical and morphological characteristics of chronic glomerulonephritis. Nefrologiya. 2018;22(5):64-70. (In Russ.). https://doi.org/10.24884/1561-6274-2018-22-5-64-70
Ibragimova KhI, Mammaev SN. Role of endothelin-1 in the pathogenesis of hypertension and its complications. Klinicheskaya gerontologiya. 2017;23(1-2):57-63. (In Russ.).
Chang IJ, Kang CJ, Yueh CY, Fang KH, Yeh RM, Tsai YT. The Relationship between Serum Lipids and Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis. PLoS One. 2015;10(4):e0121025. https://doi.org/10.1371/journal.pone.01210
Quaranta N, De Ceglie V, D’Elia A. Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review. Audiology Research. 2016;6(1):151. https://doi.org/10.4081/audiores.2016.151