The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Omarova M.A.

Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency;
Pirogov Russian National Research Medical University

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

The possibility of using multiple sclerosis-associated variants of the mitochondrial genome to predict the development of multiple sclerosis

Authors:

Omarova M.A., Boyko A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7‑2): 62‑64

DOI: 10.17116/jnevro202112107262

Views: 958

Downloaded: 21

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Omarova MA, Boyko AN. The possibility of using multiple sclerosis-associated variants of the mitochondrial genome to predict the development of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7‑2):62‑64. (In Russ.)
https://doi.org/10.17116/jnevro202112107262

 
МСФ на ЯМ
Close metadata
Recommended articles:
Biobanking in clinical trials invo­lving multiple scle­rosis patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7-2):7-15
The effe­ctiveness of tele-rehabilitation for patients with multiple scle­rosis during the COVID-19 pandemic in 2020—2021 was evaluated in this study. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):75-81
Long-term effi­cacy and safety of divo­zilimab during 2-year treatment of multiple scle­rosis patients in randomized double-blind placebo-controlled clinical trial BCD-132-4/MIRANTIBUS. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):86-96
A case of COVID-associated ence­phalopathy in a patient with multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):159-163
Opti­cal cohe­rence tomo­graphy angiography in the diagnosis of multiple scle­rosis. Russian Annals of Ophthalmology. 2024;(2):63-70
A role of cere­brovascular diseases in the progression of multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):53-57
Opti­cal cohe­rence tomo­graphy in the diagnosis of multiple scle­rosis. Russian Annals of Ophthalmology. 2024;(3):59-68
Questionnaires for arm function asse­ssment in patients with multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(6):36-42
Features of primary forms of headache in multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(6):70-73
Neurofilament light chain: a diagnostic pote­ntial for multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(6):115-119

Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by autoimmune inflammation, demyelination, and neurodegeneration. MS is a complex disease that develops under the influence of environmental factors in genetically predisposed individuals. Currently, more than 200 genetic loci associated with MS have been identified by various methods. Some of them are located in the mitochondrial DNA. This paper collects data on mtDNA variants associated with MS in the Russian ethnic group, and shows the possibility of using this information to construct and refine models for predicting the development of MS.

Keywords:

multiple sclerosis
genetic predisposition
mitochondrial genome
nuclear genome
single-nucleotide polymorphism
association
mitonuclear interactions

Authors:

Omarova M.A.

Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency;
Pirogov Russian National Research Medical University

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Received:

20.05.2021

Accepted:

26.05.2021

List of references:

  1. IMSGC. Multiple Sclerosis Genomic Map Implicates Peripheral Immune Cells and Microglia in Susceptibility. Science. 2019;365(6460):eaav7188. https://doi.org/10.1126/science.aav7188
  2. Maher B. Personal Genomes: The Case of the Missing Heritability. Nature. 2008;456(7218):18-21.  https://doi.org/10.1038/456018a
  3. Campbell G, Mahad DJ. Mitochondrial dysfunction and axon degeneration in progressive multiple sclerosis. FEBS Lett. 2018;592(7):1113-1121. https://doi.org/10.1002/1873-3468.13013
  4. Youden WJ. Index for rating diagnostic tests. Cancer. 1950;3(1):32-35. https://doi.org/10.1002/1097-0142(1950)3:1<32::aid-cncr2820030106>3.0.co;2-3 "> 3.0.co;2-3" target="_blank">https://doi.org/10.1002/1097-0142(1950)3:1<32::aid-cncr2820030106>3.0.co;2-3
  5. Kiselev I, Bashinskaya V, Baulina N, et al. differences between primary progressive and relapsing-remitting multiple sclerosis: The impact of immune-related genes variability. Mult Scler Relat Disord. 2019;29:130-136.  https://doi.org/10.1016/j.msard.2019.01.033
  6. Kozin M, Kulakova O, Kiselev I, et al. Mitonuclear interactions influence multiple sclerosis risk. Gene. 2020;758:144962. https://doi.org/10.1016/j.gene.2020.144962
  7. Kozin MS, Kulakova OG, Kiselev IS, et al. Variants of Mitochondrial Genome and Risk of Multiple Sclerosis Development in Russians. Acta Naturae. 2018;10(4):79-86. (In Russ.).
  8. Boyko AN, Kozin MS, Osmak GZh. Mitochondrial genome and risk of multiple sclerosis. Nevrologiya, neiropsikhiatriya, psikhosomatika. Neurology, Neuropsychiatry, Psychosomatics. 2019;11(3):43-46. (In Russ.). https://doi.org/10.14412/2074-2711-2019-3-43-46
  9. Kozin MS, Kulakova OG, Kiselev IS, et al. Variability of the Mitochondrial Genome and Development of the Primary Progressing form of Multiple Sclerosis. Mol Biol (Mosk). 2020;54(4):596-602. (In Russ.). https://doi.org/10.31857/S0026898420040084
  10. Kozin MS, Kiselev IS, Boyko AN, et al. The combined effect of nuclear and mitochondrial genomes on the risk of multiple sclerosis. Nevrologiya, neiropsikhiatriya, psikhosomatika. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(Part 1):15-19. (In Russ.). https://doi.org/10.14412/2074-2711-2020-1S-15-19

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.