Periodic limb movements in sleep and clinicomorphological features of cerebral small vessel disease

Spektor E.D.; Poluektov M.G.

doi:https://doi.org/10.17116/jnevro202112104275

Spektor E.D.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-0714-9476

Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-6215-0918

Periodic limb movements in sleep and clinicomorphological features of cerebral small vessel disease

Authors:

Spektor E.D., Poluektov M.G.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(4‑2): 75‑79

DOI: 10.17116/jnevro202112104275

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To cite this article:

Spektor ED, Poluektov MG. Periodic limb movements in sleep and clinicomorphological features of cerebral small vessel disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(4‑2):75‑79. (In Russ.)
https://doi.org/10.17116/jnevro202112104275

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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OBJECTIVE

To search for the association between white matter deterioration extend as well as related cognitive dysfunction and periodic limb movements in sleep (PLMS) in patients with cerebral small vessel disease (cSVD).

MATERIAL AND METHODS

Thirty-four subjects with cSVD were enrolled (12 men, 22 women, average age 66.9 y.o.). The study protocol includes nocturnal actigraphy, cardiorespiratory monitoring, cognitive assessment and brain MRI. Two groups were formed depending on PLMS index. The patients of the main group had PLMS index equal or more than 15 movements per hour, and the controls had PLMS index less than 15.

RESULTS AND CONCLUSION

The significant differences between groups are shown in the executive functioning (p=0.0025 for the Frontal Assessment battery, p=0.036 for TMT-B, p=0.009 for TMT-A) and in the volume of juxtacortical white matter hyperintensities (WMH) (p=0.009). The positive correlation of PLMS features with total and periventricular volume of WMH and the negative correlation of PLMS features with cognitive performance are found as well.

Keywords:

sleep

cerebral small vessel disease

cognitive dysfunction

magnetic resonance imaging

periodicl movement disorder

sleep disorder

Authors:

Spektor E.D.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0003-0714-9476

Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-6215-0918

Received:

19.02.2021

Accepted:

26.02.2021

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References:

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