The use of amantadine sulfate in ischemic stroke

Ramazanov G.R.; Kovaleva E.A.; Shevchenko E.V.; Akhmatkhanova L.Kh-B.

doi:https://doi.org/10.17116/jnevro202012012256

Ramazanov G.R.

Sklifosovsky Research Institute for Emergency Care

Kovaleva E.A.

Sklifosovsky Research Institute for Emergency Medicine

Shevchenko E.V.

Sklifosovsky Research Institute for Emergency Medicine

SPIN RSCI: 6658-4416
Scopus AuthorID: 57190116013
ORCID: 0000-0003-4200-1354

Akhmatkhanova L.Kh-B.

Sklifosovsky Research Institute for Emergency Medicine

The use of amantadine sulfate in ischemic stroke

Authors:

Ramazanov G.R., Kovaleva E.A., Shevchenko E.V., Akhmatkhanova L.Kh-B.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12‑2): 56‑59

DOI: 10.17116/jnevro202012012256

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To cite this article:

Ramazanov GR, Kovaleva EA, Shevchenko EV, Akhmatkhanova LKh-B. The use of amantadine sulfate in ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12‑2):56‑59. (In Russ.)
https://doi.org/10.17116/jnevro202012012256

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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OBJECTIVE

To assess the efficacy and safety of amantadine sulfate in patients with ischemic stroke.

MATERIAL AND METHODS

Ninety five patients with ischemic stroke were randomized within 120 hours from the onset of symptoms into two groups: patients of the main group received amantadine sulfate (400 mg/day intravenously) for 4 days, followed by oral administration at 400 mg/day for 6 days; the comparison group received standard therapy according to the order of the Ministry of Health of the Russian Federation No. 928n. The observation period for the patients was 90 days. The main indicators of treatment efficacy were: Glasgow Coma Scale (GCS), Modified Rankin Scale (mRS), Bartel Index (BI), National Institutes of Health Stroke Scale (NIHSS), and mortality. Any side effects were recorded to assess safety.

RESULTS AND CONCLUSION

There were no statistically significant differences between the main group and the comparison group for the main parameters. However, we observed better results in patients with mild stroke (NIHSS <13 points) and atherothrombotic pathogenetic variant of ischemic stroke. This observation should be confirmed in subsequent clinical studies.

Keywords:

amantadine sulfate

ischemic stroke

neuroprotector

Authors:

Ramazanov G.R.

Sklifosovsky Research Institute for Emergency Care

Kovaleva E.A.

Sklifosovsky Research Institute for Emergency Medicine

Shevchenko E.V.

Sklifosovsky Research Institute for Emergency Medicine

SPIN RSCI: 6658-4416
Scopus AuthorID: 57190116013
ORCID: 0000-0003-4200-1354

Akhmatkhanova L.Kh-B.

Sklifosovsky Research Institute for Emergency Medicine

Received:

07.09.2020

Accepted:

05.10.2020

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References:

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