Cognitive impairment in heart failure: the role of microcirculation abnormalities

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Chimagomedova A.Sh.

Russian Medical Academy of Continuous Professional Education

Dzhioeva Z.R.

Russian Medical Academy of Continuous Professional Education

Akhilgova Z.M.

Russian Medical Academy of Continuous Professional Education

Kurkina M.V.

Russian Medical Academy of Continuous Professional Education

Avtandilov A.G.

Russian Medical Academy of Continuous Professional Education

Cognitive impairment in heart failure: the role of microcirculation abnormalities

Authors:

Chimagomedova A.Sh., Dzhioeva Z.R., Akhilgova Z.M., Kurkina M.V., Avtandilov A.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10‑2): 54‑60

DOI: 10.17116/jnevro202012010254

Read: 8881 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Chimagomedova ASh, Dzhioeva ZR, Akhilgova ZM, Kurkina MV, Avtandilov AG. Cognitive impairment in heart failure: the role of microcirculation abnormalities. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(10‑2):54‑60. (In Russ.)
https://doi.org/10.17116/jnevro202012010254

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Animal experimental models in the study of age-dependent cerebral microangiopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3-2):57-68

The main mechanisms of development of cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):13-18

Differential diagnosis of Alzheimer’s disease and vascular cognitive disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):26-35

Cognitive impairment in patients with multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):67-73

Cognitive impairment after major surgical operations. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):74-80

Analysis of cognitive status in patients with different nosologies and clinical variants of very late manifesting schizophreniform psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):88-93

Comparative study of cognitive impairment in subgroups of bipolar affective disorder types I and II, occurring with and without psychotic symptoms. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):7-11

Relationship between stroke-associated pneumonia and long-term outcomes of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):57-61

Study of the levocarnitine efficacy for the treatment of moderate cognitive impairment in patients with hypertension. Russian Journal of Preventive Medicine. 2025;(4):45-50

Potential of animal-derived neuropeptides in complex therapy of diabetic neuropathy in patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):83-87

Abstract:

Heart failure is one of the most frequent causes predisposing to cognitive impairment where its prevalence varies from 25 to 80% of cases. In this review, the mechanisms of microcirculatory abnormalities, which play a potential role in the development of cognitive impairment in patients with heart failure, are considered. Understanding of these mechanisms will help in the development of targeted therapy of cardiovascular and cerebrovascular diseases.

Keywords:

cognitive impairment

vascular dementia

heart failure

microcirculation abnormalities

endothelial dysfunction

Authors:

Chimagomedova A.Sh.

Russian Medical Academy of Continuous Professional Education

Dzhioeva Z.R.

Russian Medical Academy of Continuous Professional Education

Akhilgova Z.M.

Russian Medical Academy of Continuous Professional Education

Kurkina M.V.

Russian Medical Academy of Continuous Professional Education

Avtandilov A.G.

Russian Medical Academy of Continuous Professional Education

Received:

15.06.2020

Accepted:

08.07.2020

Close metadata

References:

Vaenina E, Levin O, Sonin A. Modern trends in epidemiology of dementia and management of patients with cognitive impairment. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2017;117(6):87-95. https://doi.org/10.17116/jnevro20171176287-95
Gruhn N, Larsen F, Boesgaard S, Knudsen G, Mortensen S, Thomsen G, Aldershvile J. Cerebral blood flow in patients with chronic heart failure before and after heart transplantation. Stroke. 2001;2:2530-2533. https://doi.org/10.1161/hs1101.098360
Katsanos AH, Parissis J, Frogoudaki A, Vrettou AR, Ikonomidis I, Paraskevaidis I, Triantafyllou N, Kargiotis O, Voumvourakis K, Alexandrov AV, Tsivgoulis G. Heart failure and the risk of ischemic stroke recurrence: a systematic review and meta-analysis. J Neurol Sci. 2016;362:182-187. https://doi.org/10.1016/j.jns.2016.01.053
Pressler SJ, Subramanian U, Kareken D, Perkins SM, Graduz-Pizlo I, Sauvé MJ, Ding Y, Kim J, Sloan R, Jaynes H, Shaw RM. Cognitive deficits in chronic heart failure. Nurs Res. 2010;59:127-139. https://doi.org/10.1097/NNR.0b013e3181d1a747
Alwerdt J, Edwards JD, Athilingam P, O’Connor ML, Valdes EG. Longitudinal differences in cognitive functioning among older adults with and without heart failure. J Aging Health. 2013;25:1358-1377. https://doi.org/10.1177/0898264313505111
Alagiakrishnan K, Mah D, Ahmed A, Ezekowitz J. Cognitive decline in heart failure. Heart Fail Rev. 2016;21:661-673. https://doi.org/10.1007/s10741-016-9568-1
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2016;37(27):2129-2200. https://doi.org/10.1093/eurheartj/ehw128
Kitzman DW, Upadhya B, Vasu S. What the dead can teach the living: the systemic nature of eart failure with preserved ejection fraction. Circulation. 2015;131:522-524. https://doi.org/10.1161/CIRCULATIONAHA.114.014420
Lye M, Wisniacki N. Heart failure in the elderly: a diastolic problem? J Heart Failure. 2000;2(2):133-136. https://doi.org/10.1016/s1388-9842(00)00068-4
Yancy C, Lopatin M, Stevenson L. Clinical presentation, management, and inhospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function. A report from the acute decompensated heart failure national registry (ADHERE) database. Am Coll Cardiol J. 2006;47:76-84. https://doi.org/10.1016/j.jacc.2005.09.022
Mohammed SF, Borlaug BA, Roger VL, Mirzoyev SA, Rodeheffer RJ, Chirinos JA, Redfield MM. Comorbidity and Ventricular and Vascular Structure and Function in Heart Failure with Preserved Ejection Fraction: A Community Based Study. Circulation. 2012;5(6):669-671. https://doi.org/10.1161/CIRCHEARTFAILURE.112.968594
McDonagh T, Damy T, Doehner W, Lam CSP, Sindone A, van der Meer P, Cohen-Solal A, Kindermann I, Manito N, Pfister O, Pohjantähti-Maaroos H, Taylor J, Comin-Colet J. Screening, diagnosis and treatment of iron deficiency in chronic heart failure: putting the 2016 European Society of Cardiology heart failure guidelines into clinical practice. European Journal of Heart Failure. 2018;20(12):1664-1672. https://doi.org/10.1002/ejhf.1305
Van Sloten TT, Protogerou AD, Henry RM, Schram MT, Launer LJ, Stehouwer CD. Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews. 2015;53:21-30. https://doi.org/10.1016/j.neubiorev.2015.03.011
Nilsson PM. Hemodynamic aging as the consequence of structural changes associated with early vascular aging (EVA). Aging Dis. 2014;5:109-113. https://doi.org/10.14336/AD.2014.0500109
Safar ME, Levy BI, Struijker‐Boudier H. Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation. 2003;107:2864-2869. https://doi.org/10.1161/01.CIR.0000069826.36125.B4
Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. Aortic stiffness, blood pressure progression, and incident hypertension. JAMA. 2012;308:875-881. https://doi.org/10.1001/2012.jama.10503
Kurkina MV, Avtandilov AG, Krutovcev IA. The role of factors affecting the formation of chronic heart failure with preserved ejection fraction. Rational Pharmacotherapy in Cardiology. 2017;13(5):615-621.
Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25:932-943. https://doi.org/10.1161/01.ATV.0000160548.78317.29
Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium‐dependent dilation and upregulation of nuclear factor‐kappaB. Circ Res. 2007;100:16591666. https://doi.org/10.1161/01.RES.0000269183.13937.e8
Nelson MR, Stepanek J, Cevette M, Covalciuc M, Hurst RT, Tajik AJ. Noninvasive measurement of central vascular pressures with arterial tonometry: clinical revival of the pulse pressure waveform? Mayo Clin Proc. 2010;85:460-472. https://doi.org/10.4065/mcp.2009.0336
Hart CY, Meyer DM, Tazelaar HD, Grande JP, Burnett JC Jr, Housmans PR, Redfield MM. Load versus humoral activation in the genesis of early hypertensive heart disease. Circulation. 2001;104:215-220. https://doi.org/10.1161/01.cir.104.2.215
Zile MR, Gaasch WH, Patel K, Aban IB, Ahmed A. Adverse left ventricular remodeling in community‐dwelling older adults predicts incident heart failure and mortality. JACC Heart Fail. 2014;2:512-522. https://doi.org/10.1016/j.jchf.2014.03.016
Vogel MW, Slusser JP, Hodge DO, Chen HH. The natural history of preclinical diastolic dysfunction: a population‐based study. Circ Heart Fail. 2012;5:144-151. https://doi.org/10.1161/CIRCHEARTFAILURE.110.959668
Ndumele CE, Coresh J, Lazo M, Hoogeveen RC, Blumenthal RS, Folsom AR, Selvin E, Ballantyne CM, Nambi V. Obesity, subclinical myocardial injury, and incident heart failure. JACC Heart Fail. 2014;2:600-607. https://doi.org/10.1016/j.jchf.2014.05.017
Neeland IJ, Gupta S, Ayers CR, Turer AT, Rame JE, Das SR, Berry JD, Khera A, McGuire DK, Vega GL, Grundy SM, de Lemos JA, Drazner MH. Relation of regional fat distribution to left ventricular structure and function. Circ Cardiovasc Imaging. 2013;6:800-807. https://doi.org/10.1161/CIRCIMAGING.113.000532
Dengo AL, Dennis EA, Orr JS, Marinik EL, Ehrlich E, Davy BM, Davy KP. Arterial destiffening with weight loss in overweight and obese middle‐aged and older adults. Hypertension. 2010;55:855-861. https://doi.org/10.1161/HYPERTENSIONAHA.109.147850
Zebekakis PE, Nawrot T, Thijs L, Balkestein EJ, van der Heijden‐Spek J, Van Bortel LM, Struijker‐Boudier HA, Safar ME, Staessen JA. Obesity is associated with increased arterial stiffness from adolescence until old age. J Hypertens. 2005;23:1839-1846. https://doi.org/10.1097/01.hjh.0000179511.93889.e9
Otto ME, Belohlavek M, Romero‐Corral A, Gami AS, Gilman G, Svatikova A, Amin RS, Lopez‐Jimenez F, Khandheria BK, Somers VK. Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Am J Cardiol. 2007;99:1298-1302. https://doi.org/10.1016/j.amjcard.2006.12.052
Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology; American Heart Association Stroke Council; American Heart Association Council on Cardiovascular Nursing; American College of Cardiology Foundation. Circulation. 2008;118:1080-1111. Erratum in: Circulation. 2009;119:e380. https://doi.org/10.1016/j.jacc.2008.05.002
Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Journal of the American College of Cardiology. 62(4):263-271. https://doi.org/10.1016/j.jacc.2013.02.092
Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension. 2001;38(2):581-587. https://doi.org/10.1161/hy09t1.096249
Pase MP, Himali JJ, Mitchell GF, Beiser A, Maillard P, Tsao C, Larson MG, DeCarli C, Vasan RS, Seshadri S. Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study. Hypertension. 2016;67(3):513-519. https://doi.org/10.1161/HYPERTENSIONAHA.115.06610
Thorin-Trescases N, de Montgolfier O, Pinçon A, Raignault A, Caland L, Labbé P, Thorin E. Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline. American Journal of Physiology-Heart and Circulatory Physiology. 2018;314(6):1214-1224. https://doi.org/10.1152/ajpheart.00637.2017
Chertok VM. The functional morphology of the base brain arteries: thesis. Vladivostok. 1977;225:22.
Verjugina NI, Chimagomedova ASh, Sarovoitova IM, Levin OS. Endothelial dysfunction in chronic vascular encephalopathy. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2017;6(2):73-80. https://doi.org/10.17116/jnevro20171176273-80
Dimmeler F, Zeiher AM. Endothelial cells apoptosis in angiogenesis and vessel regression. Circulat Res. 2000;87:434-444. https://doi.org/10.1007/s00018-017-2577-y
Maiorana A, O’Driscoll G, Dembo L, Cheetham C, Goodman C, Taylor R, Green D. Effect of aerobic and resistance exercise training on vascular function in heart failure. Am J Physiol. 2000;279:1999-2005. https://doi.org/10.1152/ajpheart.2000.279.4.H1999
Vane J, Anggård E, Botting R. Regulatory functions of the vascular endothelium. The New England Journal of Medicine. 1990;323(1):27-36. https://doi.org/10.1056/NEJM199007053230106
Gimbrone MA. Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis. Am J Cardiol. 1995;75:67-70. https://doi.org/10.1016/0002-9149(95)80016-l
Axel R Pries, Badimon L. Coronary vascular regulation, remodelling, and collateralization: mechanisms and clinical implications on behalf of the wor-king group on coronary pathophysiology and microcirculation. European Heart Journal Advance Access published. 2015;36(43):3134-3146. https://doi.org/10.1093/eurheartj/ehv100
Achouh PE, Simonet S, Fabiani J-N, Verbeuren TJ. Carbon monoxide induces relaxation of human internal thoracic and radial arterial grafts. Interactive Cardio Vascular and Thoracic Surgery. 2008;7(6):959-962. https://doi.org/10.1510/icvts.2008.180489
Andresen JJ, Shafi NI, Durante W, Bryan RM. Effects of carbon monoxide and heme oxygenase inhibitors in cerebral vessels of rats and mice. Am J Physiol Heart Circ Physiol. 2006;291:223-230. https://doi.org/10.1152/ajpheart.00058.2006
Brian JE, Heistad DD, Faraci FM. Effect of carbon monoxide on rabbit cerebral arteries. Stroke. 1994;25:639-644. https://doi.org/10.1161/01.str.25.3.639
Johnson FK, Johnson RA. Carbon monoxide promotes endothelium dependent constriction of isolated gracilis muscle arterioles. Am J Physiol Regul Integr Comp Physiol. 2003;285:536-541. https://doi.org/10.1152/ajpregu.00624.2002
Naik JS, Walker BR. Heme-oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization. Am J Physiol Heart Circ Physiol. 2003;285:220-228. https://doi.org/10.1152/ajpheart.01131.2002
Qin X, Kwansa H, Bucci E, Dore S, Boehning D, Shugar D, Koehler R. Role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymers. Am J Physiol Regul Integr Comp Physiol. 2008;295(2):498-504. https://doi.org/10.1152/ajpregu.00188.2008
Mchedlishvili GI, Nikolajshvili LS, Antija RV. The researches of pial arte-ries response mechanisms in hyper-and hypotension. Fiziol zhurn SSSR. 1976;62(3):104-114.
Motavkin PA, Chertok VM. The histophysiology of vascular mechanisms in cerebral circulation. M.: Medicina; 1980.
De Bold AJ, Borenstein HB, Veress AT, Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981;28(1):89-94. https://doi.org/10.1016/0024-3205(81)90370-2
Tsao CW, Seshadri S, Beiser AS, Westwood AJ, DeCarli C, Au R, Himali JJ, Hamburg NM, Vita JA, Levy D, Larson MG, Benjamin EG, Wolf PA, Vasan RS, Mitchell GF. Relations of arterial stiffness and endothelial function to brain aging in the community. Neurology. 2013;81(11):984-991. https://doi.org/10.1212/WNL.0b013e3182a43e1c
Marta Smeda, Anna Kieronska, Mateusz G. Adamski, Bartosz Proniewski, Magdalena Sternak, Tasnim Mohaissen, Kamil Przyborowski, Katarzyna Derszniak, Dawid Kaczor, Marta Stojak, Elzbieta Buczek, Agnieszka Jaszta, Joanna Wietrzyk and Stefan Chlopicki. Nitric oxide deficiency and endothelial-mesenchymal transition of pulmonary endothelium in the progression of 4T1 metastatic breast cancer in mice. Breast Cancer Research. 2018;20(1):86. https://doi.org/10.1186/s13058-018-1013-z

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.