The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Tsukurova L.A.

Kraevaia klinicheskaia bol'nitsa #1 im. prof. S.V. Ochapovskogo, Krasnodar

A neuroprotective approach to optimizing treatment and correction activities in children with autism spectrum disorders

Authors:

Tsukurova L.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5‑2): 51‑56

DOI: 10.17116/jnevro20181185251

Read: 2458 times

Download PDF (RU)
Contact the author
Table of contents

A NEUROPROTECTIVE APPROACH TO OPTIMIZING TREATMENT AND CORRECTION ACTIVITIES IN CHILDREN WITH AUTISM SPECTRUM DISORDERS
A NEUROPROTECTIVE APPROACH TO OPTIMIZING TREATMENT AND CORRECTION ACTIVITIES IN CHILDREN WITH AUTISM SPECTRUM DISORDERS

To cite this article:

Tsukurova LA. A neuroprotective approach to optimizing treatment and correction activities in children with autism spectrum disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5‑2):51‑56. (In Russ.)
https://doi.org/10.17116/jnevro20181185251

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
The effect of sevo­flurane and propofol on serum nuclear and mito­chondrial DNA in pediatric patients with craniosynostosis. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):55-62
Problems of providing dental care to children using the example of the city of Chapaevsk, Samara region. Russian Journal of Operative Surgery and Clinical Anatomy. 2024;(4):35-42
Modern view on the etiology of gallstone disease in children. Russian Journal of Evidence-Based Gastroenterology. 2024;(4):59-68
Inflammatory aging. Part 1. The principal biochemical mechanisms. Russian Journal of Preventive Medi­cine. 2024;(12):145-150
Diagnostic capa­bilities of sound-breathing test in asse­ssment of pulmonary ventilation function in children and adults (retrospective review and prospect). Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(6):40-47
Risk-oriented approach to predicting exte­rnal inflammatory reso­rption in children with permanent teeth inju­ries. Stomatology. 2024;(6-2):42-46
Inflammatory aging. Part 2. Are there diagnostic biomarkers available. Russian Journal of Preventive Medi­cine. 2025;(1):89-95
Treatment of children with blunt spleen injury throughout 25-year period in Seva­stopol and the Repu­blic of Crimea. Piro­gov Russian Journal of Surgery. 2025;(2):67-76
Autoimmune diseases of central nervous system and respiratory viral infe­ctions in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):39-46
The role of gene­tic poly­morphisms in folate meta­bolism genes in the mani­festation of migraine in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):47-52
Abstract:

Objective. To study neuroprotective properties of heat shock proteins and neurotrophins in children with autism spectrum disorders (ASD). Material and methods. Sixty-eight children with ASD (ICD-10 F84), aged from 5 to 12 years, were examined. General clinical examination and evaluation of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), heat shock proteins (Hsp27, Hsp70) in the blood serum were performed. Results and conclusion. There was a decrease in NGF, BDNF, Hsp27, Hsp70 in the total group and in boys with severe ASD. These changes reflect the deterioration of neuroprotective processes in the brain in children with ASD that demands further research and development of treatment procedures.

Keywords:

autism
children
brain-derived neurotrophic factor
nerve growth factor
chaperones
heat shock proteins
Hsp27
Hsp70

Authors:

Tsukurova L.A.

Kraevaia klinicheskaia bol'nitsa #1 im. prof. S.V. Ochapovskogo, Krasnodar

Close metadata

References:

  1. Bezgodova AA, Zlokazova MV. Ehtiopatogenez rasstrojstv autisticheskogo spektra: sovremennye aspekty problemy. Materialy, posvyashchennye yubileyu professora Ya.Yu. Illeka. Vyatskij medicinskij vestnik. 2015;2:25-28. (In Russ.)
  2. Berney TP, Corbett J. Management of pervasive developmental disorders. Treating mental illness and behaviour disorders in children and adults with mental retardation. Washington, DC: American Psychiatric Press; 2001.
  3. Churkin AA, Martyushov AN. Prakticheskoe rukovodstvo po primeneniyu MKB-10 v psihiatrii i narkologii. M.: Mega Pro; 2010. (In Russ.)
  4. Marcenkovskij IA, Bikshaeva YaV, Druzhinskaya AV. Bazovye principy okazaniya medicinskoj pomoshchi detyam s obshchimi narusheniyami psihicheskogo razvitiya − rasstrojstvami spektra autizma. NejroNews: psihonevrologiya i nejropsihiatriya. 2007;2:12-19. (In Russ.)
  5. Regier DA, Kuhl EA, Kupfer DJ. DSM-5: klassifikatsiya i izmenenie kriteriev (perevod Pavlichenko AV.).World Psychiatry. 2013;12(2):88-94.
  6. Grechanina EYa. Autizm. Geneticheskie i ehpigeneticheskie problem. Scientific Journal of the Ministry of Health of Ukraine. 2013;2(3):29-47. (In Russ)
  7. Filippova NV, Baryl’nik YuB. Nejrohimicheskie aspekty ehtiopatogeneza rasstrojstv autisticheskogo spektra. Sibirskij medicinskij vestnik. 2013;8:11-15. (In Russ.)
  8. Rutter M. Progress in Understanding Autism: 2007-2010. J Autism Dev Disorders. 2011;4(41):395-404.
  9. Andreeva LI. Teoreticheskoe i prikladnoe znachenie belkov teplovogo shoka 70 kDa; vozmozhnost’ prakticheskogo primeneniya i farmakologicheskoj korrekcii. Obzory po klin. farmakologii i lek. terapii. 2002;2(1):2-18. (In Russ.)
  10. Dokladny K, Zuhl MN, Mandell M, Bhattacharya D, Schneider S, Deretic V, Moseley PL. Regulatory Coordination between Two Major Intracellular Homeostatic Systems Heat shock response and autophagy. J Biol Chem. 2013;288(21):14959-14972. https://doi.org/10.1074/jbc.M113.462408
  11. Franklin TB, Krueger-Naug AM, Clarke DB, Arrigo A-P, Curriel RW. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. Int J Hyperthermia. 2005;21(5):379-392. https://doi.org/10.1080/02656730500069955
  12. Ostrova IV, Moroz VV, Avrushchenko MSh. Znachenie immunogistohimicheskih issledovanij belkov teplovogo shoka semejstva HSP70 dlya izucheniya postreanimacionnyh izmenenij mozga. Obshchaya reanimatologiya. 2007;3:91-96. (In Russ.) https://doi.org/10.15360/1813-9779-2007-6-91-96
  13. Chernij TV, Belenichev IF, Abramov AV, Pavlov SV. Molekulyarnye mekhanizmy razrabotannoj poehtapnoj nejroprotektivnoj teapii v usloviyah ehksperimental’nogo ostrogo narusheniya mozgovogo krovoobrashcheniya. Vozmozhnaya rol’ belkov teplovogo shoka (Hsp) i faktora, inducirovannogo gipoksiej (HIF-1), v realizacii ehtogo dejstviya. Arhiv klin. i ehksperim. mediciny. 2011;20(1):72-75. (In Russ.)
  14. Belenichev IF, Pavlov SV. Vozmozhnaya rol’ Hsp-belkov v realizacii ehnergotropnogo mekhanizma nejroprotektivnogo dejstviya cerebrokurina. Nejronauki: teoreticheskie i klinicheskie aspekty. 2010;6(1):31-36. (In Russ.)
  15. Smirnov AV, Tyurenkov IN, SHmidt MV, Snigur GL, Perfilova VN, Aksenova NV, Borodin DD, Danilenko VI, Hloponin PA, Bogomolova NV, Gubanova EI. Harakteristika morfologicheskih izmenenij gippokampa staryh krys v rezul’tate stressovogo vozdejstviya. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2013;2(46):14-17. (In Russ.)
  16. Bhargava Sh, Modak SP. Expression of nerve growth factor during the development of nervous system in early chick embryo. Developmental Brain Research. 2002;136:43-49.
  17. Lindsay RM, Harmar AJ. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature. 2013;337:362-364.
  18. Hohn A, Leibrock J, Bailey K, Barde Y-A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature. 2013;344:339-341.
  19. Kale A, Joshi S, Pillai A, Naphade N, Raju M, Nasrallah H, Mahadik SP. Reduced cerebrospinal fluid and plasma nerve growth factor in drug-naïve psychotic patients. Schizophr Res. 2009. PMID 19713082.
  20. Shaposhnikova AF. Medikamentoznoe lechenie pri detskom autizme. Autizm i narusheniya razvitiya. 2008;3:43-48. (In Russ.)
  21. Matsneva EM. Autizm i naturopatiya. Chto nuzhno davat’ detyam s autizmom iz naturopaticheskih dobavok. Autizm i narusheniya razvitiya. 2007;4:1-20. (In Russ.)
  22. Kozlovskaya GV, Kalinina MA, Golubeva NI, Proselkova ME, Klyushnik TP, Brusov OS, Dupin AM, Shcherbakova IV, Boravova AI, Galkina NS. Opyt prolongirovannogo lecheniya (bolee 7 let) risperidonom rannej shizofrenii i autizma u detej. Voprosy psihicheskogo zdorov’ya detej i podrostkov. 2008;1:69-78. (In Russ.)
  23. Pyantkovskaya NS, Stecyuk RA. Primenenie nejropeptidov pri rasstrojstvah rechi u detej. Mezhdunarodnyj nevrologicheskij zhurnal. 2012;6(52):50-53. (In Russ.)
  24. Muratova LR, Vlasenko SV, Larina NV. Effektivnost’ primeneniya preparata Celleks posle parenhimatoznogo krovoizliyaniya v mozg pri ehksperimental’nom modelirovanii parenhimatoznogo krovoizliyaniya u krolikov porody shinshilla. Materialy I Vserossijskoj nauchno-prakticheskoj konferencii «Aktual’nye voprosy medicinskoj reabilitacii invalidov: kompleksnaya terapiya i mezhdisciplinarnye podhody». Mineral’nye Vody. 2017;74-77. (In Russ.)
  25. Kamchatnov PR, Chugunov AV. Metabolicheskaya terapiya v vedenii bol’nogo ishemicheskim insul’tom. Farmateka. 2014;9:38-43. (In Russ.)
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.