The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Gusev E.I.
Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva
Martynov M.Iu.
Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta
Kostenko E.V.
Poliklinika vosstanovitel'nogo lecheniia #7;
Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta;
Kafedra nevrologii Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta
Petrova L.V.
PVL #7, Moskva
Bobyreva S.N.
Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow Healthcare Department, Moscow, Russia
The efficacy of semax in the tretament of patients at different stages of ischemic stroke
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3‑2): 61‑68
Views: 12261
Downloaded: 267
To cite this article:
Gusev EI, Martynov MIu, Kostenko EV, Petrova LV, Bobyreva SN. The efficacy of semax in the tretament of patients at different stages of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry.
2018;118(3‑2):61‑68. (In Russ.)
https://doi.org/10.17116/jnevro20181183261-68
Objective. To evaluate the efficacy of semax and timing of rehabilitation on the dynamics of plasma BDNF levels, motor performance, and Barthel index score in patients after ischemic stroke (IS). Material and methods. One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined. All patients were divided into early (89±9 days) and late (214±22 days) rehabilitation groups. Each group was subdivided into semax+ and semax− subgroups. Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval. Plasma BDNF levels, motor performance on the British Medical Research Council scale and Barthel index were assessed in all groups. Results. Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period. In semax− subgroups high BDNF plasma levels were positively correlated with early rehabilitation. Administration of semax and high BDNF levels accelerated the improvement and ameliorated the final outcome of Barthel score index. There was a positive correlation between BDNF plasma levels and Barthel score, as well as a correlation between early rehabilitation and motor performance improvement. The correlation between BDNF plasma levels and Barthel score was modified by the timing of rehabilitation. Conclusions. Early rehabilitation and administration of semax increase BDNF plasma level, speed functional recovery, and improve motor performance.
Keywords:
Authors:
Gusev E.I.
Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva
Martynov M.Iu.
Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta
Kostenko E.V.
Poliklinika vosstanovitel'nogo lecheniia #7;
Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta;
Kafedra nevrologii Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta
Petrova L.V.
PVL #7, Moskva
Bobyreva S.N.
Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow Healthcare Department, Moscow, Russia
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.