The safety and efficacy of alimemazine (teraligen) in relieving anxiety in patients with alcohol addiction

Asadullin A.R.; Yuldashev V.L.; Asadullina G.M.; Akhmetova E.A.; Ishchenko K.A.

doi:https://doi.org/10.17116/jnevro20181181239-44

Asadullin A.R.

Bashkir State Medical University, Ufa, Russia

Yuldashev V.L.

Bashkir State Medical University, Ufa, Russia

Asadullina G.M.

Akmully Bashkir State Pedagogic University, Ufa, Russia

Akhmetova E.A.

Bashkir State Medical University, Ufa, Russia

Ishchenko K.A.

Corporation «Valenta Pharmaceuticals», Moscow, Russia

The safety and efficacy of alimemazine (teraligen) in relieving anxiety in patients with alcohol addiction

Authors:

Asadullin A.R., Yuldashev V.L., Asadullina G.M., Akhmetova E.A., Ishchenko K.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(1‑2): 39‑44

DOI: 10.17116/jnevro20181181239-44

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To cite this article:

Asadullin AR, Yuldashev VL, Asadullina GM, Akhmetova EA, Ishchenko KA. The safety and efficacy of alimemazine (teraligen) in relieving anxiety in patients with alcohol addiction. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(1‑2):39‑44. (In Russ.)
https://doi.org/10.17116/jnevro20181181239-44

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Objective. To assess the efficacy of monotherapy of anxiety in alcoholism with alimemazine (teraligen). Material and methods. Thirty-six patients with alcohol addiction were treated with alimemazine in dose 15 mg during 9 month. In control group (11 patients) teraligen was no used. Results and conclusion. A significant positive effect of treatment with teraligen was observed. There were the improvement in alcohol addiction course, decrease in scores on the Addiction Severity Index (ASI) from severe to mild level and decrease in trait and state anxiety measured with the Spielberger—Khanin scale from high to low levels. The reduction on symptoms of depression from moderate (at baseline) to subdepressive levels on the Beck Depression Inventory was noted in the end of treatment.

Keywords:

alcoholism

anxiety

alimemazine

teraligen

treatment

Authors:

Asadullin A.R.

Bashkir State Medical University, Ufa, Russia

Yuldashev V.L.

Bashkir State Medical University, Ufa, Russia

Asadullina G.M.

Akmully Bashkir State Pedagogic University, Ufa, Russia

Akhmetova E.A.

Bashkir State Medical University, Ufa, Russia

Ishchenko K.A.

Corporation «Valenta Pharmaceuticals», Moscow, Russia

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References:

Sivolap YuP. Alcohol abuse and related disorders treatment of alcohol dependence. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(3):4-9. (In Russ.) https://doi.org/10.14412/2074-2711-2014-3-4-9
Ivanets NN. Sovremennaya kontseptsiya terapii narkologicheskikh zabolevanii. Rukovodstvo po narkologii. Pod red. Ivantsa N.N. M.: Medpraktika-M; 2002. (In Russ.)
Abdrakhmanov DM. Anti-drug policy in contemporary Russia: the dialectic of purposes, meanings and concepts. Sotsial’naya politika i sotsiologiya. 2012;9(87):166-173. (In Russ.)
Guryleva LV, Nagornova AYu, Perevedentseva LA, Reznichenko OS, Shilova IS. Individual psychological characteristics of personslity of alcohol dependence. Sovremennye problemy nauki i obrazovaniya. 2012;6. (In Russ.)
Ilyuk RD, Berno-Bellekur IV, Torban MN, Krupitskii EM. Dinamicheskaya otsenka klinicheskikh i sotsial’nykh kharakteristik nakhodyashchikhsya na reabilitatsionnom lechenii potrebitelei opiatnykh narkotikov. Posobie dlya vrachei. NIPNI im. Bekhtereva. 2012. (In Russ.)
Agibalova TV, Tuchina OD, Shustov DI, Mukhin AA, Gurevich GL. Alcohol use reduction strategy as alternative treatment for alcohol dependence. Sotsial’naya i klinicheskaya psikhiatriya. 2015;3:61-68. (In Russ.)
Ivliyev MI, Kopylov MO, Cheremisina NV. Alcoholism in modern Russia: war for the survival. Sotsial’no-ekonomicheskie yavleniya i protsessy. Tambov. 2013;11(057):43-47. (In Russ.)
Firsenkova SV, Khaitzhanov A. The problem of «drunken» crime in contemporary Russia. Vestnik Penzenskogo gosudarstvennogo universiteta. 2014;2(6):56-59. (In Russ.)
Koshkina EA, Kuznets ME, Petrakova TI. Regional characteristics of the prevalence of alcohol consumption, drugs and other intoxicating substances among pupils of secondary vocational technical schools. Voprosy narkologii. 1990;3:30-34. (In Russ.)
Lukmanova LI, Davletshin RA, Uldashev VL, Asadullin AR, Viktorova TV. Clinical and genetic associations in alcoholic liver disease. Prakticheskaya meditsina. 2012;58:72-74. (In Russ.)
Shchetinin SG, Barylnik YuB, Lim VG. Pathogenetic aspects of alcoholic encephalopathy treatment. Saratovskii nauchno-meditsinskii zhurnal. 2010;6:4:796-799. (In Russ.)
Kushner MG, Sher KJ, Erickson DJ. Prospective analysis of the relation between DSM-III anxiety disorders and alcohol use disorders. Am J Psychiatry. 1999;156(5):723-732. https://doi.org/10.1176/ajp.156.5.723
Baving L, Olbrich H. Anxiety in alcohol-dependent patients. Fortschr Neurol Psychiatr. 1996;64(3):83-89. https://doi.org/10.1055/s-2007-996374
Johnston AL, Thevos AK, Randall CL, Anton RF. Increased severity of alcohol withdrawal in in-patient alcoholics with a co-existing anxiety diagnosis. Br J Addict. 1991;86(6):719-725. https://doi.org/10.1111/j.1360-0443.1991.tb03098.x
Terra MB, Barros HM, Stein AT, Figueira I, Athayde LD, Spanemberg L, de Aguiar Possa M, Filho LD, da Silveira DX. Does co-occurring social phobia interfere with alcoholism treatment adherence and relapse? J Subst Abuse Treat. 2006;31(4):403-409. https://doi.org/10.1016/j.jsat.2006.05.013
Driessen M, Meier S, Hill A, Wetterling T, Lange W, Junghanns K. The course of anxiety, depression and drinking behaviours after completed detoxification in alcoholics with and without comorbid anxiety and depressive disorders. Alcohol Alcohol. 2001;36(3):249-255. https://doi.org/10.1093/alcalc/36.3.249
Schellekens AF, de Jong CA, Buitelaar JK, Verkes RJ. Co-morbid anxiety disorders predict early relapse after inpatient alcohol treatment. Eur Psychiatry. 2015;30(1):128-136. https://doi.org/10.1016/j.eurpsy.2013.08.006
Bradizza CM, Stasiewicz PR, Paas ND. Relapse to alcohol and drug use among individuals diagnosed with co-occurring mental health and substance use disorders: a review. Clin Psychol Rev. 2006;26(2):162-178. https://doi.org/10.1016/j.cpr.2005.11.005
Boschloo L, Vogelzangs N, van den Brink W, Smit JH, Veltman DJ, Beekman AT, Penninx BW. Depressive and anxiety disorders predicting first incidence of alcohol use disorders: results of the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry. 2013;74(12):1233-1240. https://doi.org/10.4088/jcp.12m08159
Charriau V, Elyakoubi M, Millet B, Drapier D, Robin D, Moirand R. Generalized anxiety disorder is under-recognized in clinical practice in patients with alcohol dependence in France. Alcohol. 2013;47(1):15-19. https://doi.org/10.1016/j.alcohol.2012.08.008
Burns L, Teesson M, O’Neill K. The impact of comorbid anxiety and depression on alcohol treatment outcomes. Addiction. 2005;100:787-796. https://doi.org/10.1111/j.1360-0443.2005.001069.x
Grant BF, Hasin DS, Stinson FS, Dawson DA, Ruan J, Goldstein RB, Smith SM, Saha TD, Huang B. Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychological Medicine. 2005;35:1747-1759. https://doi.org/10.1017/s0033291705006069
Magidson JF, Liu S-M, Lejuez CW, Blanco C. Comparison of the Course of Substance Use Disorders among Individuals With and Without Generalized Anxiety Disorder in a Nationally Representative Sample. J Psychiatr Res. 2012;46(5):659-666. https://doi.org/10.1016/j.jpsychires.2012.02.011
Bruce SE, Yonkers KA, Otto MW, Eisen JL, Weisberg RB, Pagano M, Shea MT, Keller MB. Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. The American Journal of Psychiatry. 2005;162:1179-1187. https://doi.org/10.1176/appi.ajp.162.6.1179
Alegria AA, Hasin DS, Nunes EV, Liu SM, Davies C, Grant BF, Blanco C. Comorbidity of generalized anxiety disorder and substance use disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of Clinical Psychiatry. 2010;71:1187-1195. https://doi.org/10.4088/jcp.09m05328gry
Loginov SA. The use of cognitive therapy in the treatment of patients with alcoholism on the background of depressive disorders. European Research. 2016;9:77-80. (In Russ.)
Mason BJ, Fernando R, Williams LD, Ritvo EC, Cutler RB. A Double-blind, Placebo-Controlled Study of Oral Nalmefene for Alcohol Dependence. Archives of General Psychiatry. 1999;56:719-724. https://doi.org/10.1001/archpsyc.56.8.719
Blodgett JC, Del Re AC, Maisel NC, Finney JW. A meta-analysis of topiramate’s effects for individuals with alcohol use disorders. Alcohol Clin Exp Res. 2014;38(6):1481-1488. https://doi.org/10.1111/acer.12411
Maklellan T, Karize D. Indeks tyazhesti zavisimosti: versiya Treatnet. Rukovodstvo i oprosnik. M.: Verdi; 2009. (In Russ.)
Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press. 1983.
Batarshev AV. Bazovye psikhologicheskie svoistva i samoopredelenie lichnosti. Prakticheskoe rukovodstvo po psikhologicheskoi diagnostike. SPb.: Rech’; 2005. (In Russ.)
Beck AT, Steer RA, Brown GK. Beck Depression Inventory-II (BDI-II). 1996. The link is active on 03.07.2017. http://www.pearsonclinical.com/psychology/products/100000159/beck-depression-inventoryii-bdi-ii.html?Pid=015-8018-370&Mode=summary
Mezhdunarodnaya statisticheskaya klassifikatsiya boleznei i problem, svyazannykh so zdorov›em; 10-i peresmotr. Bibliotechnaya sluzhba VOZ. Perevod s angliiskogo M.V. Maksimovoi, S.K. Chemyakinoi, L.Yu. Safronovoi. Vsemirnaya organizatsiya zdravookhraneniya, 1995 (In Russ.)