Neuronet restructuring in focal and generalized epilepsy according to resting state fMRI

Mayorova L.A.; Samotaeva I.S.; Lebedeva N.N.; Luzin R.V.; Gaskin V.V.; Rider F.K.; Teplyshova A.M.; Akzhigitov R.G.; Guekht A.B.

doi:https://doi.org/10.17116/jnevro2017117924-9

Mayorova L.A.

Center for Speech Pathology and Neurorehabilitation, Moscow, Russia;
Institute of Higher Nervous Activity of RAS, Moscow, Russia

Samotaeva I.S.

Soloview Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia

Lebedeva N.N.

Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia;
Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia

Luzin R.V.

Research-Practical Psychoneurological Center, Moscow, Russia

Gaskin V.V.

Research-Practical Psychoneurological Center, Moscow, Russia

Rider F.K.

Soloviev Moscow Research and Clinical for Neuropsychiatry, Moscow, Russia

Teplyshova A.M.

Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia

Akzhigitov R.G.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology;
Soloviev Scientific and Practical Center of Psychoneurology

SPIN RSCI: 7335-7359
Scopus AuthorID: 12765937300
ResearcherID: K-2282-2018
ORCID: 0000-0001-7777-2920

Guekht A.B.

Moscow Research and Clinical Centre for Neuropsychiatry;
Pirogov Russian National Research Medical University

SPIN RSCI: 7691-3288
Scopus AuthorID: 7003326363
ResearcherID: Y-6725-2018
ORCID: 0000-0002-1170-6127

Neuronet restructuring in focal and generalized epilepsy according to resting state fMRI

Authors:

Mayorova L.A., Samotaeva I.S., Lebedeva N.N., Luzin R.V., Gaskin V.V., Rider F.K., Teplyshova A.M., Akzhigitov R.G., Guekht A.B.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9‑2): 4‑9

DOI: 10.17116/jnevro2017117924-9

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To cite this article:

Mayorova LA, Samotaeva IS, Lebedeva NN, et al. Neuronet restructuring in focal and generalized epilepsy according to resting state fMRI. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9‑2):4‑9. (In Russ.)
https://doi.org/10.17116/jnevro2017117924-9

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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Abstract:

Objective. To compare neuronet restructuring in focal and generalized epilepsy. Material and methods. Seventy-seven patients, aged from 18 to 65 years, with the diagnosis of epilepsy, including 63 patients with focal epilepsy and 14 with generalized epilepsy, were examined. A control group included 23 healthy people. Neuronet restructuring was studied using fMRI. Results and conclusion. According to resting state fMRI, there were between-group differences in spatial organization (activity map) of the brain structures as well as in the results of cross-correlation analysis of interaction maps of resting-state networks. It has been concluded that functional restructuring in connectomes in focal and generalized epilepsy have the opposite patterns of disorganization (toward increase or decrease) in most structures studied though there are structures with the same direction of connectivity changes.

Keywords:

epilepsy

focal epilepsy

generalized epilepsy

fMRI

neuronal network

restructuring

Authors:

Mayorova L.A.

Center for Speech Pathology and Neurorehabilitation, Moscow, Russia;
Institute of Higher Nervous Activity of RAS, Moscow, Russia

Samotaeva I.S.

Soloview Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia

Lebedeva N.N.

Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia;
Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia

Luzin R.V.

Research-Practical Psychoneurological Center, Moscow, Russia

Gaskin V.V.

Research-Practical Psychoneurological Center, Moscow, Russia

Rider F.K.

Soloviev Moscow Research and Clinical for Neuropsychiatry, Moscow, Russia

Teplyshova A.M.

Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia

Akzhigitov R.G.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology;
Soloviev Scientific and Practical Center of Psychoneurology

SPIN RSCI: 7335-7359
Scopus AuthorID: 12765937300
ResearcherID: K-2282-2018
ORCID: 0000-0001-7777-2920

Guekht A.B.

Moscow Research and Clinical Centre for Neuropsychiatry;
Pirogov Russian National Research Medical University

SPIN RSCI: 7691-3288
Scopus AuthorID: 7003326363
ResearcherID: Y-6725-2018
ORCID: 0000-0002-1170-6127

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References:

Sporns O, Tononi G, Kötter R. The human connectome: A structural description of the human brain. PLoS Comput Biol. 2005;1:4:245-251.
Bettus G, Guedj E, Joyeux F, et al. Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms. Hum Brain Mapp. 2009;30:5:1580-1591.
Doucet GE, Sharan A, Pustina D, et al. Early and Late Age of Seizure Onset have a Differential Impact on Brain Resting-State Organization in Temporal Lobe Epilepsy. Brain Topogr. 2015;113-126.
Bernhardt BC, Chen Z, He Y, et al. Graph-theoretical analysis reveals disrupted small-world organization of cortical thickness correlation networks in temporal lobe epilepsy. Cereb Cortex. 2011;21:9:2147-2157.
Raj A, Mueller SG, Young K, et al. Network-level analysis of cortical thickness of the epileptic brain. Neuroimage. 2010;52:4:1302-1313.
van Dellen E, Douw L, Baayen JC, et al. Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings. PLoS One. 2009;4:11:8081.
Liao W, Zhang Z, Pan Z, et al. Altered functional connectivity and small-world in mesial temporal lobe epilepsy. PLoS One. 2010;5:1:8525.
Han F, Caporale N, Dan Y. Reverberation of recent visual experience in spontaneous cortical waves. Neuron. 2008;60:2:321-327.
Shmuel A, Leopold DA. Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest. Hum Brain Mapp. 2008;29:7:751-761.
Zhang D, Raichle ME. Disease and the brain’s dark energy. Nat Rev Neurol. 2010;6:1:15-28.
Carter AR, Astafiev SV, Lang CE, et al. Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke. Ann Neurol. 2010;67:3:365-375.
Mohajerani MH, Chan AW, Mohsenvand M, et al. Spontaneous cortical activity alternates between motifs defined by regional axonal projections. Nat Neurosci. 2013;16:10:1426-1435.
Vincent JL, Patel GH, Fox MD, et al. Intrinsic functional architecture in the anaesthetized monkey brain. Nature. 2007;447:7140:83-86.
Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med. 1995;34:4:537-541.
Ji GJ, Zhang Z, Xu Q, et al. Identifying corticothalamic network epicenters in patients with idiopathic generalized epilepsy. Am J Neuroradiol. 2015;36:8:1494-1500.
Danielson NB, Guo JN, Blumenfeld H. The default mode network and altered consciousness in epilepsy. Behav Neurol. 2011;24:1:55-65.
Mason MF, Norton MI, Van Horn JD, et al. Wandering minds: the default network and stimulus-independent thought. Science. 2007;315:5810:393-395.
Zhou Y, Yu C, Zheng H, et al. Increased neural resources recruitment in the intrinsic organization in major depression. J Affect Disord. 2010;121:3:220-230.
Buchsbaum MS, Buchsbaum BR, Chokron S, et al. Thalamocortical circuits: fMRI assessment of the pulvinar and medial dorsal nucleus in normal volunteers. Neurosci Lett. 2006;404:3:282-287.
van den Heuvel MP, Stam CJ, Kahn RS, et al. Efficiency of functional brain networks and intellectual performance. J Neurosci. 2009;29:23:7619-7624.
Raichle ME, MacLeod AM, Snyder AZ, et al. A default mode of brain function. Proc Natl Acad Sci USA. 2001;98:2:676-682.
Zhang Z, Lu G, Zhong Y, et al. Impaired attention network in temporal lobe epilepsy: a resting FMRI study. Neurosci Lett. 2009;458:3:97-101.
Pravatà E, Sestieri C, Mantini D, et al. Functional connectivity MR imaging of the language network in patients with drug-resistant epilepsy. Am J Neuroradiol. 2011;32:3:532-540.
Lv Z Xia, Huang D Hong, Ye W, et al. Alteration of functional connectivity within visuospatial working memory-related brain network in patients with right temporal lobe epilepsy: A resting-state fMRI study. Epilepsy Behav Elsevier Inc. 2014;35:64-71.
Tracy JI, Doucet GE. Resting-state functional connectivity in epilepsy. Curr Opin Neurol. 2015;28:2:158-165.
Dong L, Li H, He Z, et al. Altered local spontaneous activity in frontal lobe epilepsy: a resting-state functional magnetic resonance imaging study. Brain Behav. 2016;6:11.
Dong L, Wang P, Peng R, et al. Altered basal ganglia-cortical functional connections in frontal lobe epilepsy: A resting-state fMRI study. Epilepsy Res. 2016;128:12-20.
Reuber M, Andersen B, Elger C, et al. Depressionandanxietybeforeandaftertemporallobeepilepsysurgery. Seizure. 2004;13:2:129-135.
Iwabuchi SJ, Krishnadas R, Li C, et al. Localized connectivity in depression: A meta-analysis of resting state functional imaging studies. Neurosci Biobehav Rev Elsevier Ltd. 2015;51:77-86.
Schilbach L, Müller VI, Hoffstaedter F, et al. Meta-analytically informed network analysis of resting state fMRI reveals hyperconnectivity in an introspective socio-affective network in depression. PLoS One. 2014;9:4.
Bora E, Fornito A, Pantelis C, et al. Gray matter abnormalities in Major Depressive Disorder: a meta-analysis of voxel based morphometry studies. J Affect Disord. 2012;138:1-2:9-18.
Anand A, Li Y, Wang Y, et al. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry. 2005;57:10:1079-1088.