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Nochevnaja O.M.

GBOU VPO «Altaĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet» Minzdrava RF, Barnaul

Pereverzeva O.V.

Altai State Medical University, Barnaul

Sokolova E.A.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Phillipenko M.L.

Laboratory of pharmacogenomics Institute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences, Novosibirsk, Russia

Zamyatina S.V.

Altai State Medical University, Barnaul, Russia, Altai Regional Clinical Hospital, Barnaul, Russia, Laboratory of pharmacogenomics Institute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences, Novosibirsk, Russia

Palaschenko A.S.

Altai State Medical University

Zhdanova E.S.

Altai State Medical University, Barnaul

Elchaninova S.A.

Smagina I.V.

Otdelenie nevrologii kraevoĭ klinicheskoĭ bolnitsy, Barnaul;
kafedra nervnykh bolezneĭ s kursom nevrologii i refleksoterapii fakulteta povysheniia kvalifikatsii i PPS, Barnaul;
kafedra biokhimii i klinicheskoĭ laboratornoĭ diagnostiki Altaĭskogo gosudarstvennogo meditsinskogo universiteta, Barnaul;
Novosibirskiĭ gosudarstvennyĭ universitet, Novosibirsk

The association of the FAS/APO-1 (rs2234767) gene polymorphism with the risk and rapid progression of multiple sclerosis

Authors:

Nochevnaja O.M., Pereverzeva O.V., Sokolova E.A., Phillipenko M.L., Zamyatina S.V., Palaschenko A.S., Zhdanova E.S., Elchaninova S.A., Smagina I.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2‑2): 10‑13

DOI: 10.17116/jnevro20171172210-13

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THE ASSOCIATION OF THE FAS/APO-1 (RS2234767) GENE POLYMORPHISM WITH THE RISK AND RAPID PROGRESSION OF MULTIPLE SCLEROSIS
THE ASSOCIATION OF THE FAS/APO-1 (RS2234767) GENE POLYMORPHISM WITH THE RISK AND RAPID PROGRESSION OF MULTIPLE SCLEROSIS

To cite this article:

Nochevnaja OM, Pereverzeva OV, Sokolova EA, et al. The association of the FAS/APO-1 (rs2234767) gene polymorphism with the risk and rapid progression of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2‑2):10‑13. (In Russ.)
https://doi.org/10.17116/jnevro20171172210-13

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Objective. To evaluate the association of the FAS/APO-1 (rs2234767) gene polymorphism with the risk of multiple sclerosis and its progression dynamics. Material and methods. A case-control study included 100 patients with recurrent multiple sclerosis (MS), Russians from the Altai Territory, and 100 healthy volunteers. Real-time polymerase chain reaction was used to genotype the 1377G>A polymorphism in the promoter of the FAS/APO-1 (rs2234767) gene. Association of this polymorphism with the risk of multiple sclerosis and its progression was evaluated. Results. The G/А genotype and the А-allele were associated with the increased risk of multiple sclerosis. The G/А genotype and the А-allele were associated with the risk of high progression rate of the disease. The G/G genotype and the G-allele had a protective effect. Conclusion. Predisposition to MS as well as to high progression rate are associated with the FAS/APO-1*G/А gene in Russians living in the Altai Territory. Further research is required to make the conclusion.

Keywords:

multiple sclerosis
FAS/APO-1 gene
progression rate

Authors:

Nochevnaja O.M.

GBOU VPO «Altaĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet» Minzdrava RF, Barnaul

Pereverzeva O.V.

Altai State Medical University, Barnaul

Sokolova E.A.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Phillipenko M.L.

Laboratory of pharmacogenomics Institute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences, Novosibirsk, Russia

Zamyatina S.V.

Altai State Medical University, Barnaul, Russia, Altai Regional Clinical Hospital, Barnaul, Russia, Laboratory of pharmacogenomics Institute of chemical biology and fundamental medicine, Siberian branch of the Russian Academy of Sciences, Novosibirsk, Russia

Palaschenko A.S.

Altai State Medical University

Zhdanova E.S.

Altai State Medical University, Barnaul

Elchaninova S.A.

Smagina I.V.

Otdelenie nevrologii kraevoĭ klinicheskoĭ bolnitsy, Barnaul;
kafedra nervnykh bolezneĭ s kursom nevrologii i refleksoterapii fakulteta povysheniia kvalifikatsii i PPS, Barnaul;
kafedra biokhimii i klinicheskoĭ laboratornoĭ diagnostiki Altaĭskogo gosudarstvennogo meditsinskogo universiteta, Barnaul;
Novosibirskiĭ gosudarstvennyĭ universitet, Novosibirsk

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