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Shalimov V.F.

Serbsky Federal Medical Research Center of Psychiatry and Neurology, Moscow, Russia

Suvorinova N.Iu.

Kafedra nevrologii i neĭrokhirurgii pediatricheskogo fakulteta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Nesterovsky Yu.E.

Pirogov Russian National Research Medical University, Moscow

Treatment of speech disorders in preschool children

Authors:

Shalimov V.F., Suvorinova N.Iu., Nesterovsky Yu.E.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(11‑2): 80‑87

DOI: 10.17116/jnevro201711711280-87

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To cite this article:

Shalimov VF, Suvorinova NIu, Nesterovsky YuE. Treatment of speech disorders in preschool children. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(11‑2):80‑87. (In Russ.)
https://doi.org/10.17116/jnevro201711711280-87

 
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Objective. To study the efficacy of neyroferon in developmental speech disorders (SDD). Material and methods. Thirty preschool children were stratified into 3 groups: 4—5 years (n=8), 5—6 years (n=10) and 6—7 years (n=12). The children were treated with neyroferon in dose 1 tablet three times a day during 2 month. A multifaceted study of speech disorders using several methods was conducted. General mental state, emotional and behavioral characteristics of the children were assessed as well. Results and conclusion. A therapeutic effect of neyroferon (the improvement of auditory-speech memory, expressive speech, phonemic perception, articulatory movements, vocabulary activity, connected speech etc) as well as the decrease in anxiety, hyperactivity and attention deficit was found in children with SDD. The safety of the drug was confirmed. The results should be treated as preliminary ones.

Keywords:

speech disorders
developmental speech disorders
treatment
neyroferon

Authors:

Shalimov V.F.

Serbsky Federal Medical Research Center of Psychiatry and Neurology, Moscow, Russia

Suvorinova N.Iu.

Kafedra nevrologii i neĭrokhirurgii pediatricheskogo fakulteta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Nesterovsky Yu.E.

Pirogov Russian National Research Medical University, Moscow

List of references:

  1. Kornev AN. Fundamentals of logopathology of childhood: clinical and psychological aspects. SPb.: Speech; 2006. (In Russ.)
  2. Levina RE. Delimitation of speech development anomalies in children. Defectology. 1975;2:12-16. (In Russ.)
  3. Cohen NJ, Vallance DD, Darwick M. The interface between ADHD and language impairment: An examination of language, achievement, and cognitive processing. J of Child Psychology and Psychiatry. 2000;41:353-362.
  4. Zavadenko NN. Speech development disorders in children: early diagnosis and therapy. Journal of Neurology and Psychiatry im. S.S. Korsakov. 2016;116(12):119-125. (In Russ.) https://doi.org/10.17116/jnevro2016116121119-125
  5. Bishop DVM. Motor immaturity and specific language impairment: Evidence for a common genetic basis. Amer J of Medical Genetics. 2001;114:110.
  6. Livinskaya AM. Disorders of speech development in children with attention deficit hyperactivity disorder: Dis... cand. med. nauk. SPb. 2007. (In Russ.)
  7. Bezrukova OA, Kalenkova ON. Methods for determining the level of speech development in preschool children. M. 2008;245-251. (In Russ.)
  8. Shalimov VF, Makushkin EV, Novikova GR Experience of using the drug Tenoten for children with children with mental retardation. Zh «Doktor.ru». 2009;4:46-48. (In Russ.)
  9. Shalimov VF, Nesterovsky YuN. Experience of using the drug Tenoten for children in children with a delay in the mental development of cerebral organic genesis. Effective Pharmacology. 2012;2:56-63. (In Russ.)
  10. Pereira L, Medina R, Baena M, Planas AM, Pozas E. IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche. Front Cell Neurosci. 2015;9. https://doi.org/10.3389/fncel.2015.00270
  11. Ekdahl CT, Claasen J-H, Bonde S, Kokaia Z, Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA. 2003;100(23):13632-13637. https://doi.org/10.1073/pnas.2234031100
  12. Campos AC, Vaz GN, Saito VM, Teixeira AL. Further evidence for the role of interferon-gamma on anxiety- and depressive-like behaviors: involvement of hippocampal neurogenesis and NGF production. Neurosci Lett. 2014;578:100-105. https://doi.org/10.1016/j.neulet.2014.06.039
  13. De Simone R, Levi G, Aloisi F. Interferon gamma gene expression in rat central nervous system glial cells. Cytokine. 1998;10(6):418-422. https://doi.org/10.1006/cyto.1997.0314
  14. Fantetti KN, Gray EL, Ganesan P, Kulkarni A, O’Donnell LA. Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain. J Neuroinflammation. 2016;13(1):107. https://doi.org/10.1186/s12974-016-0571-1

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