Clinical, neuropsychological and neurophysiological examination was performed in 53 patients, aged 33-75 years, in the early rehabilitation period of the first hemispheric ischemic stroke. Cognitive functions were measured with the MMSE, the FAB, the Clock Drawing Test, the 5-Word test, the Schulte probe, verbal fluency test, etc. Cognitive evoked potentials were recorded in 30 patients. Examination was carried out a month after the stroke and after 2 months of therapy with neuromidin (ipidacrinum). The control group consisted of 37 people without stroke in the case history. The statistically significant decrease of cognitive functions in comparison with control group was revealed at the first visit. The statistically significant regression of cognitive deficit, with the most distinct positive dynamics of frontal functions and semantic verbal fluency, was identified as a result of the treatment. The significant improvement in cognitive evoked potentials in the form of the reduction of P3 latency was recorded after the treatment.