The results of the study of autonomic dysregulation in anxious and anxious-melancholic endogenomorphic depression of moderate severity are presented. It was examined 36 patients with recurrent depression and depression episode (ICD-10). At functional rest, the reduction of total heart rate variability (HRV) with the maintenance of the balance of activity of sympathetic, parasympathetic and suprasegmental ergotropic systems is revealed. These data indicate a decline in adaptive potential of the organism, loss of "autonomic flexibility" and the reduced tolerance to ordinary stressors with an over-reaction to them. The orthostatic test decreases the parasympathetic reactivity, hyperactivates suprasegmental ergotropic systems and reduces the rate of activity of sympathoadrenal baroreflex mechanisms. These changes are exacerbated with patient's age, duration of affective disorder and number of depressive episodes. The changes in the functioning of regulatory systems (in particular, autonomic) in depression are quite stable, but the full recovery are not observed.