The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Totolian N.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Gotovchikov A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Lapin S.V.

Pavlov First St. Petersburg State Medical University, Russia, 197022, St. Petersburg, St. Leo Tolstoy 6/8

Maksimov I.V.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Kodzaeva A.Iu.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Prakhova L.N.

N.P. Bechtereva Institute of the Human Brain, Saint Petersburg, Russia

Il'ves A.G.

Skoromets A.P.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Totolian A.A.

NII pidemiologii i mikrobiologii im. Pastera, Sankt-Peterburg

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

Intrathecal immunoglobulin production in the diagnosis and differential diagnosis of multiple sclerosis

Authors:

Totolian N.A., Gotovchikov A.A., Lapin S.V., Maksimov I.V., Kodzaeva A.Iu., Prakhova L.N., Il'ves A.G., Skoromets A.P., Totolian A.A., Skoromets A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(9‑2): 73‑86

Read: 2794 times

Download PDF (RU)
Contact the author
Table of contents

INTRATHECAL IMMUNOGLOBULIN PRODUCTION IN THE DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF MULTIPLE SCLEROSIS
INTRATHECAL IMMUNOGLOBULIN PRODUCTION IN THE DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF MULTIPLE SCLEROSIS

To cite this article:

Totolian NA, Gotovchikov AA, Lapin SV, et al. Intrathecal immunoglobulin production in the diagnosis and differential diagnosis of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(9‑2):73‑86. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Cognitive impairment in patients with multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):67-73
Mole­cular mechanisms of acute disseminated ence­phalomyelitis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):7-11
The role of mono­cytes in the immu­nopathogenesis of multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):23-27
Resu­lts of a 5-year project for the early diagnosis of multiple scle­rosis in first-line blood rela­tives (RADIRS program). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):28-33
Current epidemiology of MS with onset in childhood and adolescence (pediatric multiple scle­rosis). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):34-38
Features of the clinical course of multiple scle­rosis as a factor in persistent disa­bility. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):39-44
Quantitative analysis of cere­brospinal fluid flow in multiple scle­rosis patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):45-50
Resu­lts of 4 years of therapy with divo­zilimab in patients with rela­psing multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):51-59
A clinical case of X-linked adre­noleukodystrophy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):102-107
Arti­ficial inte­lligence capa­bilities in multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):14-21
Abstract:

The evaluation of diagnostic significance of different immunological tests for intrathecal immunoglobulin production is summarized on the historical basis of investigation of patients with inflammatory, demyelinating and other neurological disorders. The assessment of cerebrospinal fluid lost its previous significance in the 2010 revision of diagnostic criteria for multiple sclerosis. Nowadays, it is used only for the diagnosis of primary progressive multiple sclerosis. Nevertheless, the requirements of the analysis of the cerebrospinal fluid are increasing due to subtle, subclinical and atypical cases of multiple sclerosis as well as undetermined demyelinating disorders. Intrathecal humoral immune response may be pathogenic in multiple sclerosis as suggest immunological data and effectiveness of anti-B cells treatment. Based on these tests, it is useful, to differentiate subgroups of patients and to evaluate different effects of treatment in perspective

Keywords:

multiple sclerosis
cerebrospinal fluid
intrathecal immunoglobulin synthesis

Authors:

Totolian N.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Gotovchikov A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Lapin S.V.

Pavlov First St. Petersburg State Medical University, Russia, 197022, St. Petersburg, St. Leo Tolstoy 6/8

Maksimov I.V.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Kodzaeva A.Iu.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Prakhova L.N.

N.P. Bechtereva Institute of the Human Brain, Saint Petersburg, Russia

Il'ves A.G.

Skoromets A.P.

Akademicheskaia gruppa akad. RAMN A.A. Skoromtsa (Universitet Émori - Atlanta, SShA);
Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Totolian A.A.

NII pidemiologii i mikrobiologii im. Pastera, Sankt-Peterburg

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.