In most cases, the chronic form of tick-born encephalitis (CTBE) develops after the acute phase of the disease and is characterized by polymorphic clinical manifestations. It is not often to see patients with disseminated encephalomyelitis in case of CTBE. We describe a patient with CTBE developed 12 years after the acute phase of the disease, which had a remitting course and clinically revealed multifocal lesions. MRI lesions did not differ from those caused by multiple sclerosis and the differential diagnosis of the latter was performed. The analysis of epidemiological data as well as the standard neurological examination in combination with the laboratory diagnostic methods allowed us to confirm the diagnosis of CTBE.