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Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Batysheva T.T.

Poliklinika vosstanovitel'nogo lecheniia #7

Bykova O.V.

Detskaia klinicheskaia psikhonevrologicheskaia bol'nitsa #18, kabinet detskogo rasseiannogo skleroza, Moskva

Davydovskaya M.V.

Research and Practical Centre for Clinical Investigations and Evaluation of Medical Technologies, Moscow Health Department, Moscow, Russia

Demina T.L.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Lashch N.Iu.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Nankina I.A.

Detskaia klinicheskaia psikhonevrologicheskaia bol'nitsa #18, kabinet detskogo rasseiannogo skleroza, Moskva

Ovcharov V.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza (gorodskaia klinicheskaia bol'nitsa #11 Departamenta zdravookhraneniia Moskvy);
kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universtiteta

Popova E.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Popova N.F.

kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta;
gorodskaia klinicheskaia bol'nitsa #11

Boĭko O.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza na baze Gorodskoĭ klinicheskoĭ bol'nitsy #11

Khachanova N.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Shchur S.G.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Gusev E.I.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

The comparative study of efficacy and tolerability of intramuscular introduction of beta-interferon-1a in adults and adolescents with remitting multiple sclerosis

Authors:

Boĭko A.N., Batysheva T.T., Bykova O.V., Davydovskaya M.V., Demina T.L., Lashch N.Iu., Nankina I.A., Ovcharov V.V., Popova E.V., Popova N.F., Boĭko O.V., Khachanova N.V., Shchur S.G., Gusev E.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(2‑2): 98‑103

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THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF INTRAMUSCULAR INTRODUCTION OF BETA-INTERFERON-1A IN ADULTS AND ADOLESCENTS WITH REMITTING MULTIPLE SCLEROSIS
THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF INTRAMUSCULAR INTRODUCTION OF BETA-INTERFERON-1A IN ADULTS AND ADOLESCENTS WITH REMITTING MULTIPLE SCLEROSIS

To cite this article:

Boĭko AN, Batysheva TT, Bykova OV, et al. . The comparative study of efficacy and tolerability of intramuscular introduction of beta-interferon-1a in adults and adolescents with remitting multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(2‑2):98‑103. (In Russ.)

 
Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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The experience of the treatment of patients with remitting multiple sclerosis (MS) with intramuscular introduction of beta-interferon-1a (avonex) is presented. Seventeen children and adolescents, aged from 11 to 18 years, and 55 adults, aged over 55 years, were treated for at least one-year period. Results revealed a significant reduction of exacerbations in both groups (from 1.35 to 0.06 in average in adolescents and from 0.86 to 0.17 in adults). The changes were accompanied by the stabilization of MS severity index: EDSS scores have decreased in 23.6% of adults and in 17.6% of adolescents. In both groups, good tolerability of the treatment was noted. There was a low probability of side-effects with the exception of increased frequency of a flu-like syndrome (47% cases) in patients younger than 18 years that demands special attention from children neurologists. The high efficacy and good tolerability and safety profile of beta-interferon-1a give grounds for administering this drug to children and adolescents with MS.

Keywords:

multiple sclerosis in children
beta-interferon-1a
intramuscular introduction
tolerability and safety

Authors:

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Batysheva T.T.

Poliklinika vosstanovitel'nogo lecheniia #7

Bykova O.V.

Detskaia klinicheskaia psikhonevrologicheskaia bol'nitsa #18, kabinet detskogo rasseiannogo skleroza, Moskva

Davydovskaya M.V.

Research and Practical Centre for Clinical Investigations and Evaluation of Medical Technologies, Moscow Health Department, Moscow, Russia

Demina T.L.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Lashch N.Iu.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Nankina I.A.

Detskaia klinicheskaia psikhonevrologicheskaia bol'nitsa #18, kabinet detskogo rasseiannogo skleroza, Moskva

Ovcharov V.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza (gorodskaia klinicheskaia bol'nitsa #11 Departamenta zdravookhraneniia Moskvy);
kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universtiteta

Popova E.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Popova N.F.

kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta;
gorodskaia klinicheskaia bol'nitsa #11

Boĭko O.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza na baze Gorodskoĭ klinicheskoĭ bol'nitsy #11

Khachanova N.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Shchur S.G.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Gusev E.I.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

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