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Kutlubaev M.A.

Nevrologicheskoe otdelenie Respublikanskoĭ klinicheskoĭ bol'nitsy im. G.G. Kuvatova

Akhmadeeva L.R.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

Poststroke fatigue

Authors:

Kutlubaev M.A., Akhmadeeva L.R.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4‑2): 60‑66

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Table of contents

POSTSTROKE FATIGUE
POSTSTROKE FATIGUE

To cite this article:

Kutlubaev MA, Akhmadeeva LR. Poststroke fatigue. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4‑2):60‑66. (In Russ.)

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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A study included patients, aged from 30 to 70 years, with a verified diagnosis of compensated diabetes mellitus type 1 or type 2, diabetic polyneuropathy (DPN) or the syndrome of moderate cognitive disorders (MCD). Patients with DPN were stratified into two groups: 30 patients of the main group received the antioxidant drug tiolepta in tablets (600 mg) once a day during 60 days; 30 patients of the control group received only basic (sugar-reducing) therapy. Twenty patients with MCD were treated with the combined nootropic and vasoactive drug vinpotropil in dose 2 capsules, 3 times a day during 2 months in addition to the basic therapy (sugar-reducing, antihypertensive, antiaggregate drugs). To the end of treatment, the severity of DPN was lower in the main group treated with tiolepta that reflected in the normalization of NDS scores in 50% of patients compared to 30% in the controls and in the disappearance of neurological symptoms on the TSS in 30% of patients while these symptoms were present in the control group. The electroneuromyographic study showed the statistically non-significant trend (p>0,05) to the higher velocity of impulse conduction along the sensory and motor nerves as well as higher amplitudes of motor and sensory responses in the main group. To the end of the treatment, positive dynamics in the number of complaints and neurological status was found in patients with MCD. The neuropsychological study revealed the significant (p<0,05) improvement on the MMSE scale and in the delayed recall of words (the ten words test). Adverse effects that led to discontinuation of treatment were not found for both drugs.

Keywords:

poststroke fatigue
prevalence
pathogenesis
diagnostics
treatment

Authors:

Kutlubaev M.A.

Nevrologicheskoe otdelenie Respublikanskoĭ klinicheskoĭ bol'nitsy im. G.G. Kuvatova

Akhmadeeva L.R.

Bashkirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Ufa

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