Clinical and pathogenetic rationale for complex therapeutic physical factors in patients with vasomotor rhinitis undergoing cold plasma vasotomy of inferior nasal turbinates

Belkina S.A.; Nagornev S.N.; Pelishenko T.G.

doi:https://doi.org/10.17116/rbpdpm202520415

Belkina S.A.

Clinical Hospital No. 1 of the Presidential Administration of the Russian Federation

ORCID: 0009-0000-9498-6031

Nagornev S.N.

Petrovsky National Research Center of Surgery

SPIN RSCI: 2099-3854
ORCID: 0000-0002-1190-1440

Pelishenko T.G.

Clinical Hospital No. 1 of the Presidential Administration

ORCID: 0000-0001-6597-2167

Clinical and pathogenetic rationale for complex therapeutic physical factors in patients with vasomotor rhinitis undergoing cold plasma vasotomy of inferior nasal turbinates

Authors:

Belkina S.A., Nagornev S.N., Pelishenko T.G.

More about the authors

Journal: Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;2(4): 5‑13

DOI: 10.17116/rbpdpm202520415

Read: 361 times

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To cite this article:

Belkina SA, Nagornev SN, Pelishenko TG. Clinical and pathogenetic rationale for complex therapeutic physical factors in patients with vasomotor rhinitis undergoing cold plasma vasotomy of inferior nasal turbinates. Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;2(4):5‑13. (In Russ.)
https://doi.org/10.17116/rbpdpm202520415

Подписка 2026 Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина (Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine)

Использование инфографики авторами научных работ

OBJECTIVE

To evaluate the effectiveness of infrared pulsed low-intensity laser therapy and transcranial stimulation for correction of pathological manifestations of vasomotor rhinitis after cold plasma vasotomy of inferior nasal turbinates.

MATERIAL AND METHODS

A prospective controlled, comparative randomized study involved 137 patients with vasomotor rhinitis. After cold plasma coblation, they were randomized into 4 groups. The first group (control, n=34) received only background therapy (BT), second group (comparison group 1, n=35) — course of low-intensity laser irradiation (LILI) in infrared range in addition to BT, the third group (comparison group 2, n=34) — transcranial electrical stimulation (TES) along with BT, the fourth group (main group, n=34) — LLLT combined with TES alongside BT. Clinical efficacy of physical factors was assessed using data on complaints, reactive postoperative inflammatory manifestations and SNOT-22 questionnaire. We additionally assessed autonomic nervous system using heart rate variability, parameters of microcirculatory-tissue system of nasal mucosa and severity of oxidative stress.

RESULTS

There was positive dynamics in all groups. However, additional therapeutic physical factors contributed to more significant relief of symptoms. Positive clinical dynamics were accompanied by significantly better quality of life according to SNOT-22 questionnaire. There were the best results in the group of LLLT and TES. Corrective effect of physical factors pathogenetic mechanisms on vasomotor rhinitis and reactive manifestations in postoperative period was demonstrated by positive changes in parameters characterizing autonomic nervous system, nasal mucosa perfusion and oxidative stress. LLLT had a stronger effect on tissue perfusion and antioxidant potential, TES — on autonomic regulation parameters. The highest efficacy across all parameters was recorded for LLLT and TES therapy that indicated the advantages of the developed technology.

CONCLUSION

Therapeutic physical factors with anti-inflammatory, antioxidant, and vasoactive effects, as well as reduction of autonomic dysfunction contribute to postoperative regression of clinical manifestations of vasomotor rhinitis after cold plasma coblation. Combination of LLLT and TES allows for maximum postoperative therapeutic effect due to potentiating interaction.

Keywords:

vasomotor rhinitis

low-level laser radiation

oxidative stress

transcranial electrical stimulation

cold plasma coblation

microcirculatory-tissue system

heart rate variability

Authors:

Belkina S.A.

Clinical Hospital No. 1 of the Presidential Administration of the Russian Federation

ORCID: 0009-0000-9498-6031

Nagornev S.N.

Petrovsky National Research Center of Surgery

SPIN RSCI: 2099-3854
ORCID: 0000-0002-1190-1440

Pelishenko T.G.

Clinical Hospital No. 1 of the Presidential Administration

ORCID: 0000-0001-6597-2167

Received:

10.05.2025

Accepted:

11.06.2025

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