Treatment of knee osteoarthritis with autologous stromal-vascular fraction of adipose tissue

Goncharov E.N.; Koval O.A.; Bezuglov E.N.; Goncharov N.G.; Starostenkov A.N.; Nikiforova A.E.

doi:https://doi.org/10.17116/rbpdpm2024104127

Рекомендуем статьи по данной теме:

Консервативное лечение при аваскулярном некрозе головки бедренной кости: систематический обзор. Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина. 2024;(4):52-67

Использование стандартизированной и масштабируемой методики получения стромально-васкулярной фракции из жировой ткани. Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина. 2024;(4):76-81

Экспериментальное обоснование конструкции медицинского изделия для механической обработки жировой ткани. Хирургия. Журнал им. Н.И. Пирогова. 2024;(12-2):101-108

Влияние безопиатного обезболивания на интенсивность боли и удовлетворенность пациентов после операции. Хирургия. Журнал им. Н.И. Пирогова. 2024;(12):74-80

Влияние сердечно-сосудистых осложнений на 30-дневную летальность после обширной абдоминальной операции: региональное многоцентровое исследование. Анестезиология и реаниматология. 2025;(1):69-75

Применение материалов на основе бактериальной целлюлозы в медицине. Медицинские технологии. Оценка и выбор. 2025;(1):84-91

Регенеративная активность обогащенной тромбоцитами плазмы крови в различных возрастных группах. Хирургия. Журнал им. Н.И. Пирогова. 2025;(5):36-43

Стволовые клетки, полученные из аутологичной жировой ткани, как способ лечения сложных свищей заднего прохода (систематический обзор литературы и метаанализ). Пластическая хирургия и эстетическая медицина. 2025;(2):117-127

Современные методы диагностики и эндоскопического лечения при дивертикуле Ценкера. Эндоскопическая хирургия. 2025;(3):36-43

Резюме / Abstract:

ЦЕЛЬ ОБЗОРА

Осуществить критическую оценку массива сведений о клинических эффектах SVF-терапии при лечении остеоартрита коленного сустава, представленных в зарубежной (англоязычной) литературе.

МАТЕРИАЛ И МЕТОДЫ

Выполнен обзор зарубежных публикаций, индексированных в системах PubMed, Medline и Scopus, по ключевым понятиям «SVF-терапия» («SVF»), «остеоартрит коленного сустава» («knee osteoarthritis»), «регенеративная медицина» («regenerative medicine») за период с 2017 по 2023 г. В общей сложности теме исследования соответствовали 172 публикации, в том числе 103 уникальные полнотекстовые статьи, пригодные для анализа содержания. Из них критериям отбора соответствовали 22 публикации, которые и включены в настоящий обзор.

РЕЗУЛЬТАТЫ

Имеются основания предполагать наличие ряда терапевтических преимуществ SVF-терапии. В большинстве исследований продемонстрированы эффективность и безопасность метода, положительные клинические результаты и низкий уровень нежелательных реакций, однако различия в дизайне исследований и объеме выборок требуют аккуратности в трактовке и сопоставлении их данных. Помимо положительных результатов следует учитывать методологические ограничения того или иного исследования.

ЗАКЛЮЧЕНИЕ

Применение SVF-терапии представляется многообещающим направлением, однако в приоритете всегда должны оставаться безопасность пациента и добросовестное следование научной методологии при изучении эффектов данного метода.

Ключевые слова / Keywords:

остеоартрит коленного сустава

стромально-васкулярная фракция

SVF

регенеративная медицина

клеточные технологии

хирургия

Авторы / Authors:

Гончаров Е.Н.

ФГБНУ «Российский научный центр хирургии имени академика Б.В. Петровского» Минобрнауки России

ORCID: 0000-0001-9809-7637

Коваль О.А.

ФГБНУ «Российский научный центр хирургии имени академика Б.В. Петровского» Минобрнауки России

ORCID: 0000-0002-4193-4972

Безуглов Э.Н.

ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)

ORCID: 0000-0003-3828-0506

Гончаров Н.Г.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ORCID: 0000-0001-8248-1685

Старостенков А.Н.

ФГБНУ «Российский научный центр хирургии имени академика Б.В. Петровского» Минобрнауки России

ORCID: 0009-0002-7346-9216

Никифорова А.Е.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ORCID: 0009-0009-4653-7480

Дата поступления:

10.09.2024

Дата принятия в печать:

28.09.2024

Закрыть метаданные

Литература / References:

Michael JW, Schlüter-Brust KU, Eysel P. The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Deutsches Arzteblatt International. 2010;107(9):152-162. https://doi.org/10.3238/arztebl.2010.0152
Kan HS, Chan PK, Chiu KY, Yan CH, Yeung SS, Ng YL, Shiu KW, Ho T.Non-surgical treatment of knee osteoarthritis. Hong Kong Medical Journal. 2019;25(2):127-133. https://doi.org/10.12809/hkmj187600
Skvortsov D, Kaurkin S, Prizov A, Altukhova A, Goncharov E, Nikitin A. Gait analysis and knee joint kinematics before a and 6 months after of corrective valgus osteotomy at patients with medial knee arthritis. International Orthopaedics (SICOT). 2022;46(7):1573-1582. https://doi.org/10.1007/s00264-022-05370-9
Krakowski P, Karpiński R, Jojczuk M, Nogalska A, Jonak J. Knee MRI Underestimates the Grade of Cartilage Lesions. Applied Sciences. 2021;11:1552.
Carr AJ, Robertsson O, Graves S, Price AJ, Arden NK, Judge A, Beard DJ. Knee replacement. Lancet. 2012;379(9823):1331-1340. https://doi.org/10.1016/S0140-6736(11)60752-6
Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182): 1745-1759. https://doi.org/10.1016/S0140-6736(19)30417-9
Agaverdiev M, Shamsov B, Mirzoev S, Vardikyan A, Ramirez ME, Nurmukhametov R, Beilerli A, Zhang B, Gareev I, Pavlov V. MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications — A systematic review. Non-Coding RNA Research. 2023;8(2):146-154. https://doi.org/10.1016/j.ncrna.2022.12.003
Yang Y, Lan Z, Yan J, Tang Z, Zhou L, Jin D, Jin Q. Effect of intra-knee injection of autologous adipose stem cells or mesenchymal vascular components on short-term outcomes in patients with knee osteoarthritis: An updated meta-analysis of randomized controlled trials. Arthritis Research and Therapy. 2023;25(1):147. https://doi.org/10.1186/s13075-023-03134-3
Reynoso JP, De Jesus Encarnacion M, Nurmukhametov R, Melchenko D, Efe IE, Goncharov E, Taveras AA, Ramirez Pena IJ, Montemurro N. Anatomical Variations of the Sciatic Nerve Exit from the Pelvis and Its Relationship with the Piriformis Muscle: A Cadaveric Study. Neurology International. 2022;14(4):894-902. https://doi.org/10.3390/neurolint14040072
Rodriguez-Merchan EC. Autologous and Allogenic Utilization of Stromal Vascular Fraction and Decellularized Extracellular Matrices in Orthopedic Surgery: A Scoping Review. The Archives of Bone and Joint Surgery. 2022;10(10):827-832. https://doi.org/10.22038/ABJS.2022.59635.2943
Russo A, Condello V, Madonna V, Guerriero M, Zorzi C. Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis. Journal of Experimental Orthopaedics. 2017;4(1):33. https://doi.org/10.1186/s40634-017-0108-2
Labarre KW, Zimmermann G. Infiltration of the Hoffa’s fat pad with stromal vascular fraction in patients with osteoarthritis of the knee — Results after one year of follow-up. Bone Reports. 2022;16:101168. https://doi.org/10.1016/j.bonr.2022.101168
Lapuente JP, Dos-Anjos S, Blázquez-Martínez A. Intra-articular infiltration of adipose-derived stromal vascular fraction cells slows the clinical progression of moderate-severe knee osteoarthritis: Hypothesis on the regulatory role of intra-articular adipose tissue. Journal of Orthopaedic Surgery and Research. 2020;15(1):137. https://doi.org/10.1186/s13018-020-01664-z
Garza JR, Campbell RE, Tjoumakaris FP, Freedman KB, Miller LS, Santa Maria D, Tucker BS. Clinical Efficacy of Intra-articular Mesenchymal Stromal Cells for the Treatment of Knee Osteoarthritis: A Double-Blinded Prospective Randomized Controlled Clinical Trial. The American Journal of Sports Medicine. 2020;48(3):588-598. https://doi.org/10.1177/0363546519899923
Yokota N, Hattori M, Ohtsuru T, Otsuji M, Lyman S, Shimomura K, Nakamura N. Comparative Clinical Outcomes After Intra-articular Injection With Adipose-Derived Cultured Stem Cells or Noncultured Stromal Vascular Fraction for the Treatment of Knee Osteoarthritis. The American Journal of Sports Medicine. 2019;47(11):2577-2583. https://doi.org/10.1177/0363546519864359
Rothrauff BB, Sasaki H, Kihara S, Overholt KJ, Gottardi R, Lin H, Fu FH, Tuan RS, Alexander PG. Point-of-Care Procedure for Enhancement of Meniscal Healing in a Goat Model Utilizing Infrapatellar Fat Pad-Derived Stromal Vascular Fraction Cells Seeded in Photocrosslinkable Hydrogel. The American Journal of Sports Medicine. 2019;47(14):3396-3405. https://doi.org/10.1177/0363546519880468
Koh YG, Choi YJ, Kwon SK, Kim YS, Yeo JE. Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy. 2015;23(5):1308-1316. https://doi.org/10.1007/s00167-013-2807-2
Nguyen PD, Tran TD, Nguyen HT, Vu HT, Le PT, Phan NL, Vu NB, Phan NK, Van Pham P. Comparative Clinical Observation of Arthroscopic Microfracture in the Presence and Absence of a Stromal Vascular Fraction Injection for Osteoarthritis. Stem Cells Translational Medicine. 2017;6(1):187-195. https://doi.org/10.5966/sctm.2016-0023
Muñoz-Criado I, Meseguer-Ripolles J, Mellado-López M, Alastrue-Agudo A, Griffeth RJ, Forteza-Vila J, Cugat R, García M, Moreno-Manzano V. Human Suprapatellar Fat Pad-Derived Mesenchymal Stem Cells Induce Chondrogenesis and Cartilage Repair in a Model of Severe Osteoarthritis. Stem Cells International. 2017;2017:4758930. https://doi.org/10.1155/2017/4758930
Kim YS, Suh DS, Tak DH, Kwon YB, Koh YG. Adipose-Derived Stromal Vascular Fractions Are Comparable With Allogenic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells as a Supplementary Strategy of High Tibial Osteotomy for Varus Knee Osteoarthritis. Arthroscopy, Sports Medicine, and Rehabilitation. 2023;5(3):e751-e764. https://doi.org/10.1016/j.asmr.2023.04.002
Kim YS, Oh SM, Suh DS, Tak DH, Kwon YB, Koh YG. Arthroscopic Implantation of Adipose-Derived Stromal Vascular Fraction Improves Cartilage Regeneration and Pain Relief in Patients With Knee Osteoarthritis. Arthroscopy, Sports Medicine, and Rehabilitation. 2023;5(3):e707-e716. https://doi.org/10.1016/j.asmr.2023.03.013
Boada-Pladellorens A, Avellanet M, Pages-Bolibar E, Veiga A. Stromal vascular fraction therapy for knee osteoarthritis: A systematic review. Therapeutic Advances in Musculoskeletal Disease. 2022;14:1759720X221117879. https://doi.org/10.1177/1759720X221117879
Kim YS, Oh SM, Suh DS, Tak DH, Kwon YB, Koh YG. Cartilage lesion size and number of stromal vascular fraction (SVF) cells strongly influenced the SVF implantation outcomes in patients with knee osteoarthritis. Journal of Experimental Orthopaedics. 2023;10(1):28. https://doi.org/10.1186/s40634-023-00592-1
Yokota N, Lyman S, Hanai H, Shimomura K, Ando W, Nakamura N. Clinical Safety and Effectiveness of Adipose-Derived Stromal Cell vs Stromal Vascular Fraction Injection for Treatment of Knee Osteoarthritis: 2-Year Results of Parallel Single-Arm Trials. The American Journal of Sports Medicine. 2022;50(10):2659-2668. https://doi.org/10.1177/03635465221107364
Aletto C, Giordano L, Quaranta M, Zara A, Notarfrancesco D, Maffulli N. Short-term results of intra-articular injections of stromal vascular fraction for early knee osteoarthritis. Journal of Orthopaedic Surgery and Research. 2022;17(1):310. https://doi.org/10.1186/s13018-022-03196-0
Santoprete S, Marchetti F, Rubino C, Bedini MG, Nasto LA, Cipolloni V, Pola E.Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability. Orthopedic Reviews. 2021;13(1):9161. https://doi.org/10.4081/or.2021.9161
Zhang S, Xu H, He B, Fan M, Xiao M, Zhang J, Chen D, Tong P, Mao Q. Mid-term prognosis of the stromal vascular fraction for knee osteoarthritis: A minimum 5-year follow-up study. Stem Cell Research and Therapy. 2022;13(1):105. https://doi.org/10.1186/s13287-022-02788-1
Simunec D, Salari H, Meyer J. Treatment of Grade 3 and 4 Osteoarthritis with Intraoperatively Separated Adipose Tissue-Derived Stromal Vascular Fraction: A Comparative Case Series. Cells. 2020;9(9):2096. https://doi.org/10.3390/cells9092096
Şahin AA, Değirmenci E, Özturan KE, Fırat T, Kükner A. Effects of adipose tissue-derived stromal vascular fraction on osteochondral defects treated by hyaluronic acid-based scaffold: An experimental study. Joint Diseases and Related Surgery. 2021;32(2):347-354. https://doi.org/10.52312/jdrs.2021.19
Mehling B, Hric M, Salatkova A, Vetrak R, Santora D, Ovariova M, Mihalyova R, Manvelyan M. A Retrospective Study of Stromal Vascular Fraction Cell Therapy for Osteoarthritis. Journal of Clinical Medicine Research. 2020;12(11):747-751. https://doi.org/10.14740/jocmr4354
Hudetz D, Borić I, Rod E, Jeleč Ž, Kunovac B, Polašek O, Vrdoljak T, Plečko M, Skelin A, Polančec D, Zenić L, Primorac D. Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: A prospective study. Croatian Medical Journal. 2019;60(3):227-236. https://doi.org/10.3325/cmj.2019.60.227
Hong Z, Chen J, Zhang S, Zhao C, Bi M, Chen X, Bi Q. Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: A double-blind randomized self-controlled trial. International Orthopaedics. 2019;43(5):1123-1134. https://doi.org/10.1007/s00264-018-4099-0
Tran TDX, Wu CM, Dubey NK, Deng YH, Su CW, Pham TT, Thi Le PB, Sestili P, Deng WP. Time- and KellgreñLawrence Grade-Dependent Changes in Intra-Articularly Transplanted Stromal Vascular Fraction in Osteoarthritic Patients. Cells. 2019;8(4):308. https://doi.org/10.3390/cells8040308
Bora P, Majumdar AS. Adipose tissue-derived stromal vascular fraction in regenerative medicine: A brief review on biology and translation. Stem Cell Research and Therapy. 2017;8(1):145. https://doi.org/10.1186/s13287-017-0598-y
Baer PC, Geiger H. Adipose-derived mesenchymal stromal/stem cells: Tissue localization, characterization, and heterogeneity. Stem Cells International. 2012;2012:812693. https://doi.org/10.1155/2012/812693
Francis SL, Duchi S, Onofrillo C, Di Bella C, Choong PFM. Adipose-Derived Mesenchymal Stem Cells in the Use of Cartilage Tissue Engineering: The Need for a Rapid Isolation Procedure. Stem Cells International. 2018;2018:8947548. https://doi.org/10.1155/2018/8947548
Busato A, De Francesco F, Biswas R, Mannucci S, Conti G, Fracasso G, Conti A, Riccio V, Riccio M, Sbarbati A. Simple and Rapid Non-Enzymatic Procedure Allows the Isolation of Structurally Preserved Connective Tissue Micro-Fragments Enriched with SVF. Cells. 2020;10(1):36. https://doi.org/10.3390/cells10010036
Guimarães-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans SM. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017;20(3):345-359.e5. https://doi.org/10.1016/j.stem.2016.12.006
Matsuo FS, Cavalcanti de Araújo PH, Mota RF, Carvalho AJR, Santos de Queiroz M, Baldo de Almeida B, Ferreira KCOS, Metzner RJM, Ferrari GD, Alberici LC, Osako MK. RANKL induces beige adipocyte differentiation in preadipocytes. American Journal of Physiology. Endocrinology and Metabolism. 2020;318(6):E866-E877. https://doi.org/10.1152/ajpendo.00397.2019
Contreras GA, Kabara E, Brester J, Neuder L, Kiupel M. Macrophage infiltration in the omental and subcutaneous adipose tissues of dairy cows with displaced abomasum. Journal of Dairy Science. 2015;98(9):6176-6187. https://doi.org/10.3168/jds.2015-9370
Dey A, Ni Z, Johnson MS, Sedger LM. A multi-colour confocal microscopy method for identifying and enumerating macrophage subtypes and adherent cells in the stromal vascular fraction of human adipose. Journal of Immunological Methods. 2021;491:112988. https://doi.org/10.1016/j.jim.2021.112988
Dulong J, Loisel S, Rossille D, Léonard S, Bescher N, Bezier I, Latour M, Monvoisin C, Monnier D, Bertheuil N, Roulois D, Tarte K. CD40L-expressing CD4+ T cells prime adipose-derived stromal cells to produce inflammatory chemokines. Cytotherapy. 2022;24(5):500-507. https://doi.org/10.1016/j.jcyt.2022.01.006
Gulyaeva O, Dempersmier J, Sul HS. Genetic and epigenetic control of adipose development. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 2019;1864(1):3-12. https://doi.org/10.1016/j.bbalip.2018.04.016
Mark B, Elliot L, Thomas G, Walter O, Jonathan B, Shawntae D, Sean B. Prospective Study of Autologous Adipose Derived Stromal Vascular Fraction Containing Stem Cells for the Treatment of Knee Osteoarthritis. International Journal of Stem Cell Research and Therapy. 2019;6:064.
Pers YM, Quentin J, Feirreira R, Espinoza F, Abdellaoui N, Erkilic N, Cren M, Dufourcq-Lopez E, Pullig O, Nöth U, Jorgensen C, Louis-Plence P. Injection of Adipose-Derived Stromal Cells in the Knee of Patients with Severe Osteoarthritis has a Systemic Effect and Promotes an Anti-Inflammatory Phenotype of Circulating Immune Cells. Theranostics. 2018;8(20):5519-5528. https://doi.org/10.7150/thno.27674
Cho H, Kim H, Kim YG, Kim K. Recent Clinical Trials in Adipose-derived Stem Cell Mediated Osteoarthritis Treatment. Biotechnology and Bioprocess Engineering. 2019;24:839-853.
Vargel İ, Tuncel A, Baysal N, Hartuç-Çevik İ, Korkusuz F. Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF) for Knee Osteoarthritis. International Journal of Molecular Sciences. 2022;23(21):13517. https://doi.org/10.3390/ijms232113517
Pak J, Lee JH, Pak NJ, Park KS, Jeon JH, Jeong BC, Lee SH. Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration. Journal of Visualized Experiments: JoVE. 2018;(139):58363. https://doi.org/10.3791/58363
Lattermann C, Nakamura HMN, Kon E. Early Osteoarthritis State-of-the-Art Approaches to Diagnosis, Treatment and Controversies. Springer: Heidelberg, Germany; 2022.
Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Delitala A, Bianchi F, Tremolada C, Fontani V, Ventura C. Radioelectric asymmetric conveyed fields and human adipose-derived stem cells obtained with a nonenzymatic method and device: A novel approach to multipotency. Cell Transplantation. 2014;23(12):1489-500. https://doi.org/10.3727/096368913X672037
Montemurro N, Pierozzi E, Inchingolo AM, Pahwa B, De Carlo A, Palermo A, Scarola R, Dipalma G, Corsalini M, Inchingolo AD, Inchingolo F, Rapone B. New biograft solution, growth factors and bone regenerative approaches in neurosurgery, dentistry, and orthopedics: A review. European Review for Medical and Pharmacological Sciences. 2023;27(16):7653-7664. https://doi.org/10.26355/eurrev_202308_33419
Perdisa F, Gostyńska N, Roffi A, Filardo G, Marcacci M, Kon E. Adipose-Derived Mesenchymal Stem Cells for the Treatment of Articular Cartilage: A Systematic Review on Preclinical and Clinical Evidence. Stem Cells International. 2015;2015:597652. https://doi.org/10.1155/2015/597652
Aronowitz JA, Ellenhorn JDI. Adipose stromal vascular fraction isolation: A head-to-head comparison of four commercial cell separation systems. Plastic and Reconstructive Surgery. 2013;132:932e-939e. https://doi.org/10.1097/PRS.0b013e3182a80652
Packer JD, Chang WT, Dragoo JL. The use of vibrational energy to isolate adipose-derived stem cells. Plastic and Reconstructive Surgery — Global Open. 2018;6(1):e1620. https://doi.org/10.1097/GOX.0000000000001620
Dragoo JL, Chang W. Arthroscopic Harvest of Adipose-Derived Mesenchymal Stem Cells from the Infrapatellar Fat Pad. The American Journal of Sports Medicine. 2017;45(13):3119-3127. https://doi.org/10.1177/0363546517719454
Aronowitz JA, Lockhart RA, Hakakian CS, Birnbaum ZE. Adipose stromal vascular fraction isolation: A head-to-head comparison of 4 cell separation systems# 2. Annals of Plastic Surgery. 2016;77(3):354-62. https://doi.org/10.1097/SAP.0000000000000831
Domenis R, Lazzaro L, Calabrese S, Mangoni D, Gallelli A, Bourkoula E, Manini I, Bergamin N, Toffoletto B, Beltrami CA, Beltrami AP, Cesselli D, Parodi PC. Adipose tissue derived stem cells: In vitro and in vivo analysis of a standard and three commercially available cell-assisted lipotransfer techniques. Stem Cell Research and Therapy. 2015;6(1):2. https://doi.org/10.1186/scrt536
Fang C, Patel P, Li H, Huang LT, Wan H, Collins S, Connell TL, Xu H. Physical, biochemical, and biologic properties of fat graft processed via different methods. Plastic and Reconstructive Surgery — Global Open. 2020;8(8):e3010. https://doi.org/10.1097/GOX.0000000000003010
Tremolada C, Colombo V, Ventura C. Adipose tissue and mesenchymal stem cells: State of the art and Lipogems® technology development. Current Stem Cell Reports. 2016;2(3):304-312. https://doi.org/10.1007/s40778-016-0053-5
Magnanelli S, Screpis D, Di Benedetto P, Natali S, Causero A, Zorzi C. Open-wedge high tibial osteotomy associated with lipogems® intra-articular injection for the treatment of varus knee osteoarthritis–retrospective study. Acta Bio-Medica. 2020;91(14-S):e2020022.
Kavala AA, Turkyilmaz S. Autogenously derived regenerative cell therapy for venous leg ulcers. Archives of Medical Sciences. Atherosclerotic Diseases. 2018;3:e156-e163. https://doi.org/10.5114/amsad.2018.81000
Lobascio P, Balducci G, Minafra M, Laforgia R, Fedele S, Conticchio M, Palasciano N. Adipose-derived stem cells (MYSTEM® EVO Technology) as a treatment for complex transsphincteric anal fistula. Techniques in Coloproctology. 2018;22(5):373-377. https://doi.org/10.1007/s10151-018-1785-2
Stevens HP, van Boxtel J, van Dijck R, van Dongen JA. Platelet Rich STROMA, the Combination of PRP and tSVF and Its Potential Effect on Osteoarthritis of the Knee. Applied Sciences. 2020;10:4691.
Copcu HE. Supercharged Mechanical Stromal-cell Transfer (MEST). Plastic and Reconstructive Surgery — Global Open. 2021;9:e3552. https://doi.org/10.1097/GOX.0000000000003552
Zocchi ML, Facchin F, Pagani A, Bonino C, Sbarbati A, Conti G, Vindigni V, Bassetto F. New perspectives in regenerative medicine and surgery: The bioactive composite therapies (BACTs). European Journal of Plastic Surgery. 2022;45(1):1-25. https://doi.org/10.1007/s00238-021-01874-6
Rossi M, Roda B, Zia S, Vigliotta I, Zannini C, Alviano F, Bonsi L, Zattoni A, Reschiglian P, Gennai A. Characterization of the Tissue and Stromal Cell Components of Micro-Superficial Enhanced Fluid Fat Injection (Micro-SEFFI) for Facial Aging Treatment. Aesthetic Surgery Journal. 2020;40(6):679-690. https://doi.org/10.1093/asj/sjy142
Cohen SR, Tiryaki T, Womack HA, Canikyan S, Schlaudraff KU, Scheflan M. Cellular Optimization of Nanofat: Comparison of Two Nanofat Processing Devices in Terms of Cell Count and Viability. Aesthetic Surgery Journal. Open Forum. 2019;1(4):ojz028. https://doi.org/10.1093/asjof/ojz028
Tiryaki KT, Cohen S, Kocak P, Canikyan Turkay S, Hewett S. In-Vitro Comparative Examination of the Effect of Stromal Vascular Fraction Isolated by Mechanical and Enzymatic Methods on Wound Healing. Aesthetic Surgery Journal. 2020;40(11):1232-1240. https://doi.org/10.1093/asj/sjaa154
Sesé B, Sanmartín JM, Ortega B, Matas-Palau A, Llull R. Nanofat Cell Aggregates: A Nearly Constitutive Stromal Cell Inoculum for Regenerative Site-Specific Therapies. Plastic and Reconstructive Surgery. 2019;144(5):1079-1088. https://doi.org/10.1097/PRS.0000000000006155
Caforio M, Nobile C. Intra-Articular Administration of Autologous Purified Adipose Tissue Associated with Arthroscopy Ameliorates Knee Osteoarthritis Symptoms. Journal of Clinical Medicine. 2021;10(10):2053. https://doi.org/10.3390/jcm10102053
Ferguson RE, Cui X, Fink BF, Vasconez HC, Pu LL. The viability of autologous fat grafts harvested with the LipiVage system: A comparative study. Annals of Plastic Surgery. 2008;60(5):594-597. https://doi.org/10.1097/SAP.0b013e31817433c5
Котенко К.В., Еремин И.И., Мороз Б.Б., Бушманов А.Ю., Надежина Н.М., Галстян И.А., Гринаковская О.С., Аксененко А.В., Дешевой Ю.Б., Лебедев В.Г., Слободина Т.С., Жгутов Ю.А., Лаук-Дубицкий С.Е., Еремин П.С. Клеточные технологии в лечении радиационных ожогов: опыт ФМБЦ им. А.И. Бурназяна. Клеточная трансплантология и тканевая инженерия. 2012;7(2):97-102.
Kotenko K, Moroz B, Nadezhina N, Galstyan I, Eremin I, Deshevoy J, Lebedev V, Slobodina T, Grinakovskaya D, Zhgutov Y, Bushmanov A. Successful treatment of localised radiation lesions in rats and humans by mesenchymal stem cell transplantation. Radiation Protection Dosimetry. 2012;151(4):661-665. https://doi.org/10.1093/rpd/ncs177
Котенко К.В., Уйба В.В., Корчажкина Н.Б., Петрова М.С., Михайлова А.А., Галкин Г.Н. Инструкция по проведению дополнительных методов обследования и реабилитации спортсменов. М. 2012.
Корчажкина Н.Б., Михайлова А.А., Ковалев С.А., Портнов В.В., Ржевский В.С. Эффективность методик ранней реабилитации в программах ускоренного выздоровления больных после хирургических вмешательств. Физиотерапия, бальнеология и реабилитация. 2019;18(6):408-411. https://doi.org/10.17816/1681-3456-2019-18-6-408-411
Корчажкина Н.Б. Третий этап медицинской реабилитации в условиях санаторно-курортных организаций. Дальнейшее развитие санаторно-курортного лечения после оказания специализированной, в том числе высокотехнологичной медицинской помощи. Курортная медицина. 2013;3:69-72.
Котенко К.В., Уйба В.В., Корчажкина Н.Б., Петрова М.С., Киш А.А., Михайлова А.А. Повышение функциональных возможностей организма спортсменов циклических видов спорта. Медицина труда и промышленная экология. 2013;9:42-44.