Treatment of knee osteoarthritis with autologous stromal-vascular fraction of adipose tissue

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OBJECTIVE

To assess available foreign data on clinical effects of SVF therapy in the treatment of knee osteoarthritis.

MATERIAL AND METHODS

We review foreign articles in the PubMed, Medline and Scopus databases using the keywords “SVF therapy”, “knee osteoarthritis”, “regenerative medicine” between 2017 and 2023. There were 172 manuscripts including 103 unique full-text articles suitable for analysis. Of these, 22 manuscripts met the selection criteria.

RESULTS

There are some therapeutic advantages of SVF therapy. Most studies demonstrated the efficacy and safety of this technique, positive clinical results and low incidence of adverse reactions. However, different study design and sample size require caution in interpretation and comparison of results. In addition to positive results, it is necessary to understand methodological limitations of a particular study.

CONCLUSION

SVF therapy appears to be a promising direction. However, patient safety and conscientious adherence to scientific methodology should always remain a priority.

Keywords:

knee osteoarthritis

stromal vascular fraction

SVF

regenerative medicine

cellular technologies

surgery

Authors:

Goncharov E.N.

Petrovsky National Rsearch Centre of Surgery

ORCID: 0000-0001-9809-7637

Koval O.A.

Petrovsky National Rsearch Centre of Surgery

ORCID: 0000-0002-4193-4972

Bezuglov E.N.

Sechenov First Moscow State Medical University

ORCID: 0000-0003-3828-0506

Goncharov N.G.

Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0001-8248-1685

Starostenkov A.N.

Petrovsky National Rsearch Centre of Surgery

ORCID: 0009-0002-7346-9216

Nikiforova A.E.

Russian Medical Academy of Continuous Professional Education

ORCID: 0009-0009-4653-7480

Received:

10.09.2024

Accepted:

28.09.2024

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