Лечение остеоартрита коленного сустава аутологичной стромально-васкулярной фракцией жировой ткани: обзор зарубежной литературы

Закрыть метаданные

ЦЕЛЬ ОБЗОРА

Осуществить критическую оценку массива сведений о клинических эффектах SVF-терапии при лечении остеоартрита коленного сустава, представленных в зарубежной (англоязычной) литературе.

МАТЕРИАЛ И МЕТОДЫ

Выполнен обзор зарубежных публикаций, индексированных в системах PubMed, Medline и Scopus, по ключевым понятиям «SVF-терапия» («SVF»), «остеоартрит коленного сустава» («knee osteoarthritis»), «регенеративная медицина» («regenerative medicine») за период с 2017 по 2023 г. В общей сложности теме исследования соответствовали 172 публикации, в том числе 103 уникальные полнотекстовые статьи, пригодные для анализа содержания. Из них критериям отбора соответствовали 22 публикации, которые и включены в настоящий обзор.

РЕЗУЛЬТАТЫ

Имеются основания предполагать наличие ряда терапевтических преимуществ SVF-терапии. В большинстве исследований продемонстрированы эффективность и безопасность метода, положительные клинические результаты и низкий уровень нежелательных реакций, однако различия в дизайне исследований и объеме выборок требуют аккуратности в трактовке и сопоставлении их данных. Помимо положительных результатов следует учитывать методологические ограничения того или иного исследования.

ЗАКЛЮЧЕНИЕ

Применение SVF-терапии представляется многообещающим направлением, однако в приоритете всегда должны оставаться безопасность пациента и добросовестное следование научной методологии при изучении эффектов данного метода.

Ключевые слова:

остеоартрит коленного сустава

стромально-васкулярная фракция

SVF

регенеративная медицина

клеточные технологии

хирургия

Авторы:

Гончаров Е.Н.

ФГБНУ «Российский научный центр хирургии имени академика Б.В. Петровского» Минобрнауки России

ORCID: 0000-0001-9809-7637

Коваль О.А.

ФГБНУ «Российский научный центр хирургии имени академика Б.В. Петровского» Минобрнауки России

ORCID: 0000-0002-4193-4972

Безуглов Э.Н.

ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)

ORCID: 0000-0003-3828-0506

Гончаров Н.Г.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ORCID: 0000-0001-8248-1685

Старостенков А.Н.

ФГБНУ «Российский научный центр хирургии имени академика Б.В. Петровского» Минобрнауки России

ORCID: 0009-0002-7346-9216

Никифорова А.Е.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ORCID: 0009-0009-4653-7480

Дата поступления:

10.09.2024

Дата принятия в печать:

28.09.2024

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