Predictors of effective complex physiotherapy in patients with skin involution

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OBJECTIVE

To evaluate the predictors of effective complex physiotherapeutic correction of skin involution in middle-aged and older women.

MATERIAL AND METHODS

The study included 30 women with metabolic syndrome. We analyzed the parameters characterizing skin involution. We estimated objective parameters of facial skin (hydration, elasticity, oiliness, pH), microcirculation processes and subjective indicators (dermatological quality of life index, visual scale of facial skin condition, international aesthetic improvement scale). Assessment of metabolic syndrome was based on insulin resistance index, body mass index and atherogenicity coefficient. Additionally, we analyzed pro- and antioxidant system, as well as cytokine status. Complex physiotherapeutic correction of facial skin involution included hyaluronic acid laser phoresis, transcranial magnetic therapy and oxygen barotherapy. We analyzed the predictors of effective therapy using regression analysis, matrix and multiple correlations.

RESULTS

Matrix correlation analysis of 23 indicators characterizing baseline condition of patients established obvious multiple collinearity. This required reducing the number of independent variables to five including transepidermal water loss, microcirculation index, oxygen consumption rate, insulin resistance index and interleukin IL-4. Standardized coefficients of multiple regression equation showed that the first three indicators were significant predictors of effectiveness. Metabolic disorders minimally determined the effectiveness of physiotherapeutic correction. Effectiveness of treatment is maximum at minimal deviations of the above-mentioned independent variables from normal values. Multiple linear regression for normalized indicators (forecast accuracy more than 90%) was the most adequate while logistic model and piecewise regression demonstrated lower predictive quality.

CONCLUSION

Physiotherapeutic technologies have a high therapeutic potential for effective correction of skin involution. Different physical nature of preformed factors provides a multimodal systemic effect on pathological processes slowing down skin aging. Maximum results become possible in case of integrated use of therapeutic physical factors for initial imbalance in various functional systems.

Keywords:

skin involution

metabolic syndrome

complex physiotherapy

regression analysis

Authors:

Danilov A.A.

Love Clinic

ORCID: 0009-0001-3272-2521

Mikhailova A.A.

FSBSI «Petrovsky National Research Centre of Surgery»

ORCID: 0000-0002-4260-1619

Frolkov V.K.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-1277-5183

Received:

25.01.2024

Accepted:

12.02.2024

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