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Tsvetkova A.V.

Group of companies «MEDSI»;
Sechenov First Moscow State Medical University

Koneva E.S.

Center of Restorative Medicine of the MEDSI group;
Sechenov First Moscow State Medical University

Kostenko A.A.

City Clinical Hospital No. 52

Bisheva D.R.

Sechenov First Moscow State Medical University

Sidyakina I.V.

Group of companies «MEDSI»

Konev S.M.

Sechenov First Moscow State Medical University;
Group of companies «MEDSI»

Zhumanova E.N.

Center of gynecology, oncology, reproductive and aesthetic medicine in Clinical hospital No. 1 of JSC GC «Medsi», Krasnogorsk, Otradnoe;
Central state medical Academy of the presidential administration of the Russian Federation

Illarionov V.E.

Central state medical Academy of the presidential administration of the Russian Federation

Shestakov A.V.

FGBNU "Russian Scientific Center for Surgery named after acad. B.V. Petrovsky Russian Research Center for Surgery

The role of systemic ozone therapy in the rehabilitation of patients after COVID-19

Authors:

Tsvetkova A.V., Koneva E.S., Kostenko A.A., Bisheva D.R., Sidyakina I.V., Konev S.M., Zhumanova E.N., Illarionov V.E., Shestakov A.V.

More about the authors

Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2022;99(4‑2): 22‑29

DOI: 10.17116/kurort20229904222

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Table of contents

THE ROLE OF SYSTEMIC OZONE THERAPY IN THE REHABILITATION OF PATIENTS AFTER COVID-19
THE ROLE OF SYSTEMIC OZONE THERAPY IN THE REHABILITATION OF PATIENTS AFTER COVID-19

To cite this article:

Tsvetkova AV, Koneva ES, Kostenko AA, et al. . The role of systemic ozone therapy in the rehabilitation of patients after COVID-19. Problems of Balneology, Physiotherapy and Exercise Therapy. 2022;99(4‑2):22‑29. (In Russ.)
https://doi.org/10.17116/kurort20229904222

Подписка 2026 Вопросы курортологии, физиотерапии и лечебной физической культуры (Problems of Balneology, Physiotherapy and Exercise Therapy)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the effectiveness and safety of ozone therapy in rehabilitation of patients with previous COVID-19.

MATERIAL AND METHODS

A randomized controlled clinical trial included 51 patients aged 29 - 78 years with SARS-CoV-2 pneumonia (J12.8). Patients were divided into 3 comparable groups depending on the complex of rehabilitation. In the first (control) group (n=17), a 10-day course included daily breathing exercises and physiotherapy for the lungs (drug electrophoresis and low-frequency magnetotherapy). In the second (main) group (n=18), rehabilitation was combined with daily intravenous infusions of ozonized saline with ozone concentration of 2.0 mg/l within 5 days with subsequent standard rehabilitation. In the third group (n=16), patients received 5 ozone therapy procedures every other day. To determine the effectiveness and safety of systemic ozone therapy in rehabilitation of patients with previous COVID-19, we analyzed oxygen saturation, laboratory data (D-dimer and C-reactive protein), need for oxygen support before and after rehabilitation course. Complaints and quality of life throughout the rehabilitation program were assessed using the EQ-5D questionnaire.

RESULTS

All patients had positive changes of all parameters. There were no adverse reactions throughout the rehabilitation program and 2 months later. We observed higher effectiveness of rehabilitation with systemic ozone therapy. Moreover, daily ozone therapy had a better effect on laboratory parameters compared to ozone therapy every other day.

CONCLUSION

Ozone therapy is safe and effective in complex rehabilitation of patients with previous COVID-19. Further studies of large samples are needed to determine indications and appropriate criteria for this rehabilitation program.

Keywords:

COVID-19
SARS-CoV-2
rehabilitation
physiotherapy
ozone

Authors:

Tsvetkova A.V.

Group of companies «MEDSI»;
Sechenov First Moscow State Medical University

Koneva E.S.

Center of Restorative Medicine of the MEDSI group;
Sechenov First Moscow State Medical University

Kostenko A.A.

City Clinical Hospital No. 52

Bisheva D.R.

Sechenov First Moscow State Medical University

Sidyakina I.V.

Group of companies «MEDSI»

Konev S.M.

Sechenov First Moscow State Medical University;
Group of companies «MEDSI»

Zhumanova E.N.

Center of gynecology, oncology, reproductive and aesthetic medicine in Clinical hospital No. 1 of JSC GC «Medsi», Krasnogorsk, Otradnoe;
Central state medical Academy of the presidential administration of the Russian Federation

Illarionov V.E.

Central state medical Academy of the presidential administration of the Russian Federation

Shestakov A.V.

FGBNU "Russian Scientific Center for Surgery named after acad. B.V. Petrovsky Russian Research Center for Surgery

Received:

31.05.2022

Accepted:

04.08.2022

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