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Tsvetkova A.V.
Group of companies «MEDSI»;
Sechenov First Moscow State Medical University
Koneva E.S.
Center of Restorative Medicine of the MEDSI group;
Sechenov First Moscow State Medical University
Kostenko A.A.
City Clinical Hospital No. 52
Bisheva D.R.
Sechenov First Moscow State Medical University
Konev S.M.
Sechenov First Moscow State Medical University;
Group of companies «MEDSI»
Zhumanova E.N.
Center of gynecology, oncology, reproductive and aesthetic medicine in Clinical hospital No. 1 of JSC GC «Medsi», Krasnogorsk, Otradnoe;
Central state medical Academy of the presidential administration of the Russian Federation
Illarionov V.E.
Central state medical Academy of the presidential administration of the Russian Federation
Shestakov A.V.
FGBNU "Russian Scientific Center for Surgery named after acad. B.V. Petrovsky Russian Research Center for Surgery
The role of systemic ozone therapy in the rehabilitation of patients after COVID-19
Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2022;99(4‑2): 22‑29
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To cite this article:
Tsvetkova AV, Koneva ES, Kostenko AA, et al. . The role of systemic ozone therapy in the rehabilitation of patients after COVID-19. Problems of Balneology, Physiotherapy and Exercise Therapy.
2022;99(4‑2):22‑29. (In Russ.)
https://doi.org/10.17116/kurort20229904222
To evaluate the effectiveness and safety of ozone therapy in rehabilitation of patients with previous COVID-19.
A randomized controlled clinical trial included 51 patients aged 29 - 78 years with SARS-CoV-2 pneumonia (J12.8). Patients were divided into 3 comparable groups depending on the complex of rehabilitation. In the first (control) group (n=17), a 10-day course included daily breathing exercises and physiotherapy for the lungs (drug electrophoresis and low-frequency magnetotherapy). In the second (main) group (n=18), rehabilitation was combined with daily intravenous infusions of ozonized saline with ozone concentration of 2.0 mg/l within 5 days with subsequent standard rehabilitation. In the third group (n=16), patients received 5 ozone therapy procedures every other day. To determine the effectiveness and safety of systemic ozone therapy in rehabilitation of patients with previous COVID-19, we analyzed oxygen saturation, laboratory data (D-dimer and C-reactive protein), need for oxygen support before and after rehabilitation course. Complaints and quality of life throughout the rehabilitation program were assessed using the EQ-5D questionnaire.
All patients had positive changes of all parameters. There were no adverse reactions throughout the rehabilitation program and 2 months later. We observed higher effectiveness of rehabilitation with systemic ozone therapy. Moreover, daily ozone therapy had a better effect on laboratory parameters compared to ozone therapy every other day.
Ozone therapy is safe and effective in complex rehabilitation of patients with previous COVID-19. Further studies of large samples are needed to determine indications and appropriate criteria for this rehabilitation program.
Keywords:
Authors:
Tsvetkova A.V.
Group of companies «MEDSI»;
Sechenov First Moscow State Medical University
Koneva E.S.
Center of Restorative Medicine of the MEDSI group;
Sechenov First Moscow State Medical University
Kostenko A.A.
City Clinical Hospital No. 52
Bisheva D.R.
Sechenov First Moscow State Medical University
Konev S.M.
Sechenov First Moscow State Medical University;
Group of companies «MEDSI»
Zhumanova E.N.
Center of gynecology, oncology, reproductive and aesthetic medicine in Clinical hospital No. 1 of JSC GC «Medsi», Krasnogorsk, Otradnoe;
Central state medical Academy of the presidential administration of the Russian Federation
Illarionov V.E.
Central state medical Academy of the presidential administration of the Russian Federation
Shestakov A.V.
FGBNU "Russian Scientific Center for Surgery named after acad. B.V. Petrovsky Russian Research Center for Surgery
Received:
31.05.2022
Accepted:
04.08.2022
List of references:
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