The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kokorina V.E.

Postgraduate Institute for Public Health Workers, Surgical Department

Bykov I.A.

Far Eastern State Medical University Public Health and Healthcare Department;
Harbin Medical University School of Public Health Social Medicine Department

The optimization in the rehabilitation of anosmia after SARS-CoV-2 infection

Authors:

Kokorina V.E., Bykov I.A.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2022;87(1): 33‑38

DOI: 10.17116/otorino20228701133

Views: 1952

Downloaded: 157

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Kokorina VE, Bykov IA. The optimization in the rehabilitation of anosmia after SARS-CoV-2 infection. Russian Bulletin of Otorhinolaryngology. 2022;87(1):33‑38. (In Russ.)
https://doi.org/10.17116/otorino20228701133

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Olfa­ctory, gustatory and audi­tory diso­rders asso­ciated with COVID-19. A systematic review of their distribution and pathogenesis. Russian Bulletin of Otorhinolaryngology. 2023;(6):61-66
Asse­ssment of labo­ratory para­meters at various COVID-19 phases in patients with gastrointestinal symptoms. Russian Journal of Evidence-Based Gastroenterology. 2023;(4):89-94
Complications and gestational outcomes in women with new SARS-CoV-2 coro­navirus infe­ction during pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2023;(6-2):167-172
Moni­toring spread of SARS-CoV-2 gene variants in Sverdlovsk and Chelyabinsk regions and Perm krai. Mole­cular Gene­tics, Microbiology and Viro­logy. 2023;(4):15-20
Invo­lvement of the trigeminal nerve system in the sense of smell. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(12):7-12
Plasmic hemo­stasis evaluation by thro­mbodynamics in indi­viduals booster dose vaccination against SARS-CoV-2. Russian Journal of Preventive Medi­cine. 2023;(12):88-94
Late diagnosis of rhinocerebral muco­rmycosis in patients with COVID-19 (case studies). Russian Annals of Ophthalmology. 2023;(6):110-121
Clinical and labo­ratory para­meters and pathomorphological features of the lungs in patients who have had COVID-19 viral pneumonia. Russian Journal of Archive of Pathology. 2024;(1):27-35
Study of olfa­ctory thre­shold using Russian version of Sniffin’ Sticks test. Russian Rhinology. 2024;(1):6-10
Analysis of the effe­ctiveness of modern asse­ssing olfa­ction questionnaires. Russian Rhinology. 2024;(1):33-38

During SARS-CoV-2 pandemic number of patients with olfactory disorders caused by new coronavirus infection substantially increased, making their rehabilitation an issue of the day. We analyzed influence of the drug Sinupret on the restoration dynamic of the olfactory dysfunction associated with SARS-CoV-2 infection. 187 patients with impaired sense of smell associated with SARS-CoV-2 infection were included in this study: test group consisted of 104 cases in which olfactory training methods were combined with the prescription of the drug Sinupret. Control group consisted of 84 patients those undergone olfactory training alone. During study period in 26 patients restoration of the olfactory disorders have not been achieved, due to the virus induced neurodegenerative nature of the lesion. It was observed that in test group odor detection threshold restoration was on average 3.6 days faster than in control group. At the same time, the use of Sinupret was associated with a statistically significant 29.4% decrease of antibiotic prescription frequency for bacterial complications of SARS-CoV-2. Therefore, we assume that the positive effect of Sinupret on SARS-CoV-2 associated anosmia is caused by its antiviral, secretolytic, anti-inflammatory, decongestant and moderately antibacterial effects in the olfactory epithelium.

Keywords:

SARS-CoV-2 virus
anosmia
sense of smell restoration
Sinupret

Authors:

Kokorina V.E.

Postgraduate Institute for Public Health Workers, Surgical Department

Bykov I.A.

Far Eastern State Medical University Public Health and Healthcare Department;
Harbin Medical University School of Public Health Social Medicine Department

Received:

20.12.2021

Accepted:

24.12.2021

List of references:

  1. Kryukov AI, Kazakova AA, Gekht AB. Olfactory impairment in COVID-19 patients: mechanisms and clinical significance. Vestnik otorinolaringologii. 2020;85(5):93-97. (In Russ.). https://doi.org/10.17116/otorino20208505193
  2. Gane SB, Kelly C, Hopkins C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology. 2020;58(3): 299-301.  https://doi.org/10.4193/Rhin20.114
  3. Wang K, Chen W, Zhang Z, Deng Y, Lian JQ, Du P, Wei D, Zhang Y, Sun XX, Gong L, Yang X, He L, Zhang L, Yang Z, Geng JJ, Chen R, Zhang H, Wang B, Zhu YM, Nan G, Jiang JL, Li L, Wu J, Lin P, Huang W, Xie L, Zheng ZH, Zhang K, Miao JL, Cui HY, Huang M, Zhang J, Fu L, Yang XM, Zhao Z, Sun S, Gu H, Wang Z, Wang CF, Lu Y, Liu YY, Wang QY, Bian H, Zhu P, Chen ZN. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. Signal Transduction and Targeted Therapy. 2020;5(1):283.  https://doi.org/10.1038/s41392-020-00426-x
  4. Savvateeva DM, Lopatin AS. Diagnosis and treatment of olfactory dysfunction in patients with acute rhinosinusitis. Rossijskaya rinologiya. 2010;18(2):8-11. (In Russ.).
  5. Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, Damm M, Frasnelli J, Gudziol H, Gupta N, Haehne A, Holbrook E, Hong SC, Hornung D, Hüttenbrink KB, Kamel R, Kobayashi M, Konstantinidis I, Landis BN, Leopold DA, Macchi A, Miwa T, Moesges R, Mullol J, Mueller CA, Ottaviano G, Passali GC, Philpott C, Pinto JM, Ramakrishnan VJ, Rombaux P, Roth Y, Schlosser RA, Shu B, Soler G, Stjärne P, Stuck BA, Vodicka J, Welge-Luessen A. Position paper on olfactory dysfunction. Rhinology. Supplement. 2017;54(26):1-30.  https://doi.org/10.4193/Rhino16.248
  6. Kalogjera L. EPOS 2020-New Classification and Rhinosinusitis Treatment Guidelines. Medica Jadertina. 2020;50:22. 
  7. Howell DC. Chi-Square Test: Analysis of Contingency Tables. 2011. https://doi.org/10.1007/978-3-642-04898-2_174
  8. Cook RD. Detection of influential observation in linear regression. Technometrics. 1977;19(1):15-18. 
  9. Blaine BE. Winsorizing. The SAGE Encyclopedia of Educational Research, Measurement, and Evaluation. 2018:1817-1818.
  10. Zou KH, Tuncali K, Silverman SG. Correlation and simple linear regression. Radiology. 2003;227(3):617-622.  https://doi.org/10.1148/radiol.2273011499
  11. Maxwell SE, O’Callaghan MF, Delaney HD. Analysis of Covariance. 1993.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.