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Kokorina V.E.

Postgraduate Institute for Public Health Workers, Surgical Department

Bykov I.A.

Far Eastern State Medical University Public Health and Healthcare Department;
Harbin Medical University School of Public Health Social Medicine Department

The optimization in the rehabilitation of anosmia after SARS-CoV-2 infection

Authors:

Kokorina V.E., Bykov I.A.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2022;87(1): 33‑38

DOI: 10.17116/otorino20228701133

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THE OPTIMIZATION IN THE REHABILITATION OF ANOSMIA AFTER SARS-COV-2 INFECTION
THE OPTIMIZATION IN THE REHABILITATION OF ANOSMIA AFTER SARS-COV-2 INFECTION

To cite this article:

Kokorina VE, Bykov IA. The optimization in the rehabilitation of anosmia after SARS-CoV-2 infection. Russian Bulletin of Otorhinolaryngology. 2022;87(1):33‑38. (In Russ.)
https://doi.org/10.17116/otorino20228701133

Подписка 2025-2 (Russian Bulletin of Otorhinolaryngology)
 
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During SARS-CoV-2 pandemic number of patients with olfactory disorders caused by new coronavirus infection substantially increased, making their rehabilitation an issue of the day. We analyzed influence of the drug Sinupret on the restoration dynamic of the olfactory dysfunction associated with SARS-CoV-2 infection. 187 patients with impaired sense of smell associated with SARS-CoV-2 infection were included in this study: test group consisted of 104 cases in which olfactory training methods were combined with the prescription of the drug Sinupret. Control group consisted of 84 patients those undergone olfactory training alone. During study period in 26 patients restoration of the olfactory disorders have not been achieved, due to the virus induced neurodegenerative nature of the lesion. It was observed that in test group odor detection threshold restoration was on average 3.6 days faster than in control group. At the same time, the use of Sinupret was associated with a statistically significant 29.4% decrease of antibiotic prescription frequency for bacterial complications of SARS-CoV-2. Therefore, we assume that the positive effect of Sinupret on SARS-CoV-2 associated anosmia is caused by its antiviral, secretolytic, anti-inflammatory, decongestant and moderately antibacterial effects in the olfactory epithelium.

Keywords:

SARS-CoV-2 virus
anosmia
sense of smell restoration
Sinupret

Authors:

Kokorina V.E.

Postgraduate Institute for Public Health Workers, Surgical Department

Bykov I.A.

Far Eastern State Medical University Public Health and Healthcare Department;
Harbin Medical University School of Public Health Social Medicine Department

Received:

20.12.2021

Accepted:

24.12.2021

List of references:

  1. Kryukov AI, Kazakova AA, Gekht AB. Olfactory impairment in COVID-19 patients: mechanisms and clinical significance. Vestnik otorinolaringologii. 2020;85(5):93-97. (In Russ.). https://doi.org/10.17116/otorino20208505193
  2. Gane SB, Kelly C, Hopkins C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology. 2020;58(3): 299-301.  https://doi.org/10.4193/Rhin20.114
  3. Wang K, Chen W, Zhang Z, Deng Y, Lian JQ, Du P, Wei D, Zhang Y, Sun XX, Gong L, Yang X, He L, Zhang L, Yang Z, Geng JJ, Chen R, Zhang H, Wang B, Zhu YM, Nan G, Jiang JL, Li L, Wu J, Lin P, Huang W, Xie L, Zheng ZH, Zhang K, Miao JL, Cui HY, Huang M, Zhang J, Fu L, Yang XM, Zhao Z, Sun S, Gu H, Wang Z, Wang CF, Lu Y, Liu YY, Wang QY, Bian H, Zhu P, Chen ZN. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. Signal Transduction and Targeted Therapy. 2020;5(1):283.  https://doi.org/10.1038/s41392-020-00426-x
  4. Savvateeva DM, Lopatin AS. Diagnosis and treatment of olfactory dysfunction in patients with acute rhinosinusitis. Rossijskaya rinologiya. 2010;18(2):8-11. (In Russ.).
  5. Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, Damm M, Frasnelli J, Gudziol H, Gupta N, Haehne A, Holbrook E, Hong SC, Hornung D, Hüttenbrink KB, Kamel R, Kobayashi M, Konstantinidis I, Landis BN, Leopold DA, Macchi A, Miwa T, Moesges R, Mullol J, Mueller CA, Ottaviano G, Passali GC, Philpott C, Pinto JM, Ramakrishnan VJ, Rombaux P, Roth Y, Schlosser RA, Shu B, Soler G, Stjärne P, Stuck BA, Vodicka J, Welge-Luessen A. Position paper on olfactory dysfunction. Rhinology. Supplement. 2017;54(26):1-30.  https://doi.org/10.4193/Rhino16.248
  6. Kalogjera L. EPOS 2020-New Classification and Rhinosinusitis Treatment Guidelines. Medica Jadertina. 2020;50:22. 
  7. Howell DC. Chi-Square Test: Analysis of Contingency Tables. 2011. https://doi.org/10.1007/978-3-642-04898-2_174
  8. Cook RD. Detection of influential observation in linear regression. Technometrics. 1977;19(1):15-18. 
  9. Blaine BE. Winsorizing. The SAGE Encyclopedia of Educational Research, Measurement, and Evaluation. 2018:1817-1818.
  10. Zou KH, Tuncali K, Silverman SG. Correlation and simple linear regression. Radiology. 2003;227(3):617-622.  https://doi.org/10.1148/radiol.2273011499
  11. Maxwell SE, O’Callaghan MF, Delaney HD. Analysis of Covariance. 1993.

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