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Rumyantseva Z.S.

Crimean Federal University named after V.I. Vernadsky

Sulima A.N.

Crimean Federal University named after V.I. Vernadsky

Miklin O.P.

Crimean Federal University named after V.I. Vernadsky

Gudz O.V.

Crimean Federal University named after V.I. Vernadsky

Yermachkova P.A.

Crimean Federal University named after V.I. Vernadsky

Kallmann syndrome in the practice of an obstetrician-gynecologist

Authors:

Rumyantseva Z.S., Sulima A.N., Miklin O.P., Gudz O.V., Yermachkova P.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(4): 106‑111

DOI: 10.17116/repro202430041106

Read: 1243 times

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Table of contents

KALLMANN SYNDROME IN THE PRACTICE OF AN OBSTETRICIAN-GYNECOLOGIST
KALLMANN SYNDROME IN THE PRACTICE OF AN OBSTETRICIAN-GYNECOLOGIST

To cite this article:

Rumyantseva ZS, Sulima AN, Miklin OP, Gudz OV, Yermachkova PA. Kallmann syndrome in the practice of an obstetrician-gynecologist. Russian Journal of Human Reproduction. 2024;30(4):106‑111. (In Russ.)
https://doi.org/10.17116/repro202430041106

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Kallmann syndrome is a rare, genetically determined combination of gonadotropin-releasing hormone deficiency and hypo- and anosmia. It is reported to occur in 1:10.000 men and 1:50.000 women. The main genes in which mutations in KS are found are KAL1, NSMF, WDR11, GNRHR, and others. In addition to disorders of sexual development and olfaction, KS can manifest as agenesis of the kidneys, teeth, polydactyly, scoliosis, and lesions of the nervous system. Treatment of KS in women includes the use of estrogen-progestin therapy to induce and maintain the development of secondary sexual characteristics and gonadotropin therapy to ensure fertility. In this paper we describe a case of diagnostics and treatment of a 20-year-old female patient, who had been trying to find the cause of her condition for a long time without success before coming to our clinic.

Keywords:

Kallmann syndrome
case report
anosmia
hypogonadotropic hypogonadism
gonadotropin-releasing hormone

Authors:

Rumyantseva Z.S.

Crimean Federal University named after V.I. Vernadsky

Sulima A.N.

Crimean Federal University named after V.I. Vernadsky

Miklin O.P.

Crimean Federal University named after V.I. Vernadsky

Gudz O.V.

Crimean Federal University named after V.I. Vernadsky

Yermachkova P.A.

Crimean Federal University named after V.I. Vernadsky

Received:

20.06.2023

Accepted:

08.09.2023

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References:

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