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Kolesnik S.V.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Borzenok S.A.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Ostrovskiy D.S.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Zhuravlev A.S.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Kolesnik A.I.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Khubetsova M.Kh.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Kerimov T.Z.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Morphologic types of idiopathic epiretinal fibrosis based on immunohistochemistry data

Authors:

Kolesnik S.V., Borzenok S.A., Ostrovskiy D.S., Zhuravlev A.S., Kolesnik A.I., Khubetsova M.Kh., Kerimov T.Z.

More about the authors

Journal: Russian Annals of Ophthalmology. 2026;142(1): 36‑44

DOI: 10.17116/oftalma202614201136

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Table of contents

MORPHOLOGIC TYPES OF IDIOPATHIC EPIRETINAL FIBROSIS BASED ON IMMUNOHISTOCHEMISTRY DATA
MORPHOLOGIC TYPES OF IDIOPATHIC EPIRETINAL FIBROSIS BASED ON IMMUNOHISTOCHEMISTRY DATA

To cite this article:

Kolesnik SV, Borzenok SA, Ostrovskiy DS, Zhuravlev AS, Kolesnik AI, Khubetsova MKh, Kerimov TZ. Morphologic types of idiopathic epiretinal fibrosis based on immunohistochemistry data. Russian Annals of Ophthalmology. 2026;142(1):36‑44. (In Russ.)
https://doi.org/10.17116/oftalma202614201136

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The least studied component of idiopathic epiretinal membranes (iERMs), one of the manifestations of which is known as idiopathic epiretinal fibrosis (iERF), is the extracellular matrix (ECM). Investigation of the qualitative and quantitative composition of the ECM, as well as the structural organization of its components, may be useful for determining the clinical course of iERF.

PURPOSE

This study aimed to identify features of the protein profile and architecture of iERMs and to assess various variants of development and clinical course of the disease.

MATERIAL AND METHODS

The study included 32 patients who underwent surgery for iERF. Standard ophthalmologic examinations and optical coherence tomography (OCT) were performed. During surgical treatment, excised tissue was collected for immunohistochemical (IHC) analysis. Membrane specimens were fixed according to the proposed method of the author, followed by IHC analysis.

RESULTS

Three morphological types of iERMs were identified, differing in ECM composition, degree of adhesion to the retinal internal limiting membrane (ILM), postoperative visual acuity and visual quality parameters, and the dynamics of their growth.

CONCLUSION

Determination of iERM morphological types using IHC methods may serve as a prognostic factor for postoperative visual acuity and the dynamics of visual recovery in iERF.

Keywords:

epiretinal fibrosis
epiretinal membrane
internal limiting membrane
immunohistochemistry

Authors:

Kolesnik S.V.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Borzenok S.A.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Ostrovskiy D.S.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Zhuravlev A.S.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Kolesnik A.I.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Khubetsova M.Kh.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia

Kerimov T.Z.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Received:

09.05.2025

Accepted:

18.06.2025

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References:

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  2. Xiao W, Chen X, Yan W, Zhu Z, He M. Prevalence and risk factors of epiretinal membranes: a systematic review and meta-analysis of population-based studies. BMJ Open. 2017;7(9):e014644. https://doi.org/10.1136/bmjopen-2016-014644
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