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Saakyan S.V.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Svirina I.V.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia

Tsygankov A.Yu.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Loginov V.I.

Institute of General Pathology and Pathophysiology, Moscow, Russia

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, Moscow, Russia

Association of clinical and morphological tumor characteristics with the status of chromosomes 1, 3, and 8 in iris melanoma

Authors:

Saakyan S.V., Svirina I.V., Tsygankov A.Yu., Loginov V.I., Burdennyy A.M.

More about the authors

Journal: Russian Annals of Ophthalmology. 2026;142(1): 28‑35

DOI: 10.17116/oftalma202614201128

Read: 345 times

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Table of contents

ASSOCIATION OF CLINICAL AND MORPHOLOGICAL TUMOR CHARACTERISTICS WITH THE STATUS OF CHROMOSOMES 1, 3, AND 8 IN IRIS MELANOMA
ASSOCIATION OF CLINICAL AND MORPHOLOGICAL TUMOR CHARACTERISTICS WITH THE STATUS OF CHROMOSOMES 1, 3, AND 8 IN IRIS MELANOMA

To cite this article:

Saakyan SV, Svirina IV, Tsygankov AYu, Loginov VI, Burdennyy AM. Association of clinical and morphological tumor characteristics with the status of chromosomes 1, 3, and 8 in iris melanoma. Russian Annals of Ophthalmology. 2026;142(1):28‑35. (In Russ.)
https://doi.org/10.17116/oftalma202614201128

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Abstract:

There is only a limited number of studies devoted to the molecular genetic status of patients with iris melanoma.

PURPOSE

This study aimed to analyze the frequency of chromosomal aberrations in tumor tissue in patients with iris melanoma.

MATERIAL AND METHODS

Data from 140 patients with uveal melanoma (UM) treated between 2006 and 2023 were analyzed. Group A included 48 patients with iris melanoma, group B — 62 patients with iris melanoma with extension into the ciliary body. Group C (comparison group) consisted of 30 patients with choroidal melanoma treated in 2012. Subsequently, patients were divided into four subgroups according to chromosomal alterations. Additional subgroups with combinations of two or more aberrations were also identified. All tumors were histologically verified.

RESULTS

The spindle cell tumor type was observed significantly more frequently in the 1p+8p subgroup (A) compared with the M3+1p subgroup (A) (p<0.05), whereas the mixed cell type was more common in the M3+1p subgroup (A) than in the 1p+8p subgroup (A) (p<0.05). A significant association was found between the frequency of partial monosomy of chromosome 3 and mixed cell and epithelioid cell tumor types (p<0.05) in the partial M3 subgroup (C). In iris melanoma, deletion of the entire short arm of chromosome 1 was detected in 68.7% of cases and of chromosome 8 in 47.9%; in tumors with extension into the ciliary body, this was observed in 77.4% and 51.6% of cases, respectively, whereas in choroidal melanoma — in 30% and 20% of cases, respectively.

CONCLUSION

The present study showed for the first time that deletions of the short arms of chromosomes 1 and 8 are detected 2.5 times more frequently, and monosomy of chromosome 3 occurs 1.5 times less frequently in iris melanoma compared to choroidal melanoma. The revealed features confirm the more favorable biological behavior of iris melanomas compared to choroidal melanomas.

Keywords:

iris melanoma
monosomy of chromosome 3
deletion of chromosome 1
deletion of chromosome 8

Authors:

Saakyan S.V.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Svirina I.V.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia

Tsygankov A.Yu.

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia;
Russian University of Medicine, Moscow, Russia

Loginov V.I.

Institute of General Pathology and Pathophysiology, Moscow, Russia

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, Moscow, Russia

Received:

06.10.2024

Accepted:

25.11.2024

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References:

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