The role of endothelin-1 in the pathogenesis of familial exudative vitreoretinopathy

Katargina LA, Chesnokova NB, Denisova EV, Geraskina EA, Pavlenko TA, Beznos OV, Lisovskaja OA. The role of endothelin-1 in the pathogenesis of familial exudative vitreoretinopathy. Russian Annals of Ophthalmology. 2023;139(5):14‑18. (In Russ.)
https://doi.org/10.17116/oftalma202313905114

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

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PURPOSE

The study evaluates the possible role of endothelin-1 in the pathogenesis of FEVR.

MATERIAL AND METHODS

The study included 85 patients with FEVR aged from 1 months to 17 years who were examined in Helmholtz National Medical Research Center of Eye Diseases. The concentration of ET-1 was evaluated in 19 patients with FEVR in the blood serum (n=17), lacrimal fluid (n=18) and 16 patients from the control group.

RESULTS

The median of ET-1 in the lacrimal fluid in patients with FEVR was 13.74 pg/mL, respectively, which exceeded the same indicator of the control group 4.66 pg/mL by 2.5 times (p<0.001). The median of ET-1 in the blood serum exceeded the control group by 2.4 times (21.61 pg/mL and 9.21 pg/mL, respectively, p<0.001).

CONCLUSIONS

An increase in the concentration of ET-1 in the lacrimal fluid and blood serum of patients with FEVR in comparison with the control group indicates its involvement in the pathogenesis of the disease.

Keywords:

familial exudative vitreoretinopathy

endothelin-1

pathogenesis

vitreoretinal pathology in children

Authors:

Katargina L.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-4857-0374

Chesnokova N.B.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-7856-8005

Denisova E.V.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0003-3735-6249

Geraskina E.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-5306-2534

Pavlenko T.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-8032-4248

Beznos O.V.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-7557-4955

Lisovskaja O.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-7787-8581

Received:

16.03.2022

Accepted:

15.04.2022

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