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Sviridenko N.Yu.

National Medical Research Center for Endocrinology

Sheremeta M.S.

Scientific Medical Research Center of Endocrinology

Belovalova I.M.

Scientific Medical Research Center of Endocrinology

Melnichenko G.A.

National Medical Center of Endocrinology

Treatment of Graves’ disease in patients with thyroid eye disease

Authors:

Sviridenko N.Yu., Sheremeta M.S., Belovalova I.M., Melnichenko G.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(6): 128‑135

Read: 7414 times


To cite this article:

Sviridenko NYu, Sheremeta MS, Belovalova IM, Melnichenko GA. Treatment of Graves’ disease in patients with thyroid eye disease. Russian Annals of Ophthalmology. 2021;137(6):128‑135. (In Russ.)
https://doi.org/10.17116/oftalma2021137061128

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References:

  1. Kahaly GJ, Bartalena L, Hegedus L, et al. European Thyroid Association Guideline for the management of Graves Hyperthyroidism. Eur Thyroid J. 2018;7(4):167-186.  https://doi.org/10.1159/000490384
  2. Bartalena L, Piantanida E, Gallo D, et al. Epidemiology, Natural History, Risk Factors, and Prevention of Graves’ Orbitopathy. Front Endocrinol. 2020;11:913.  https://doi.org/10.3389/fendo.2020.615993
  3. Bartallena L, Pinchera A, Marcocci C. Management of Graves’ ophthalmopathy: Reality and Perspectives. Endocrine Rev. 2000;21(2):168-199.  https://doi.org/10.1210/edrv.21.2.0393
  4. Autoimmunnaya patologiya shchitovidnoy zhelezy i endokrinnaya oftal’mopatiya [Autoimmune pathology of the thyroid gland and endocrine ophthalmopathy]. Eds Dedov II, Melnichenko GA. Moscow: Izdatel’stvo Printing affairs master; 2020 (In Russ.).
  5. Brovkina AF. Endocrinnaya ofthal’mopatiya. [Endocrine ophthalmopathy]. M.: GEOTAR-Media; 2008. (In Russ.).
  6. Russian Association of Endocrinologists. Natsional’nyye rekomendatsii: Tireotoksikoz s diffuznym zobom (diffuznyy toksicheskiy zob, bolezn’ Greyvsa—Bazedova), uzlovym/mnogouzlovym zobom [National recommendations: Thyrotoxicosis with diffuse goiter (diffuse toxic goiter, Graves-Bazedov disease), nodular/multi-nodular goiter]. M. 2014. (In Russ.).
  7. Sviridenko NYu, Likhantseva VG, Belovalova IM, et al. Anti-TSH receptor antibodies as predictors of the severity and outcome of endocrine ophthalmopathy in the patients presenting with Graves’ disease. Problemy endokrinologii = Problems of Endocrinology. 2011;57(2):23-26. (In Russ.). https://doi.org/10.14341/probl201157223-26
  8. Diana T, Krause J, Olivo PD, et al. Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease. Clin Exp Immunol. 2017;189:304-309.  https://doi.org/10.1111/cei.12980
  9. Yang DD, Gonzalez MO, Durairaj VD. Medical management of thyroid eye disease. Saudi J Ophthalmol. 2011;25(1):3-13.  https://doi.org/10.1016/j.sjopt.2010.10.001
  10. Rapoport B, McLachlan SM. TSH receptor cleavage into subunits and shedding of the Asubunit; a molecular and clinical perspective. Endocr Rev. 2016;37:114-134.  https://doi.org/10.1210/er.2015-1098
  11. Wall JR, Lahooti H. Pathogenesis of thyroid eye disease — does autoimmunity against the TSH receptor explain all cases? Endokrynol Pol. 2010;61(2): 222-227. 
  12. Diana T, Wüster C, Olivo PD, et al. Performance and Specificity of 6 Immunoassays for TSH Receptor Antibodies: A Multicenter Study. Eur Thyroid J. 2017;6(5):243-249.  https://doi.org/10.1159/000478522
  13. Bartalena L, Baldeschi L, Boboridis K, et al. The 2016 European Thyroid Association/European Group on Graves’ Orbitopathy Guidelines for the Management of Graves’ Orbitopathy. Eur Thyroid J 2016;5:9-26.  https://doi.org/10.1159/000443828
  14. Ross DS. Radioiodine Treatment in Patients with Graves’ Disease. In: Graves’ Disease. Vol 6. New York, NY: Springer New York; 2015;83-98.  https://doi.org/10.1007/978-1-4939-2534-6_7
  15. Rumyantsev PO, Sheremeta MS, Sviridenko NYu, Trukhin AA. Therapy with radioactive iodine. In: Endokrinologiya. Natsional’noye rukovodstvo [Endocrinology. National guideline]. Eds Dedova II, Melnichenko GA. M.: GEOTAR-Media; 2020. (In Russ.).
  16. Acharya SH, Avenell A, Philip S, et al. Radioiodine therapy (RAI) for Graves’disease (GD) and the effect on ophthalmopathy: a systematic review. Clin Endocrinol (Oxf). 2008;69(6):943-950.  https://doi.org/10.1111/j1365-2265.2008.03279.x
  17. Pinchera A, Bartalena L, Marcocci C. Therapeutic controversies. Radioiodine may be bad for Graves’ ophthalmopathy, but… J Clin Endocrinol Metab. 1995;80:342-345.  https://doi.org/10.1210/jcem. 80.2.7852486
  18. Aizawa Y, Yoshida K, Kaise N, et al. Long-term effects of radioiodine on thyrotrophin receptor antibodies in Graves’ disease. Clin. Endocrinol. 1995; 4:517-522.  https://doi.org/10.1111/j.1365-2265.1995.tb02671.x
  19. Dreval AV, Tsyb AF, Nechaeva OA, et al. Effects of Radioiodine Therapy on the Natural History of Graves’ Ophtalmopathy. Klinicheskaya i eksperimental’naya tireoidologiya = Clinical and experimental thyroidology. 2007;3(3): 33-40 (In Russ.). https://doi.org/10.14341/ket20073333-40
  20. Vestergaard P. Smoking and thyroid disorders — a meta-analysis. Eur J Endocrinol. 2002;146(2):153-161.  https://doi.org/10.1530/eje.0.1460153
  21. Plazinska MT, Sawicka-Gutaj N, Czarnywojtek A, et al. Radioiodine therapy and Graves’ disease — Myths and reality. PLoS ONE. 2020;15(1): e0226495. https://doi.org/10.1371/journal.pone.0226495
  22. Stan MN, Bahn RS. Risk factors for development or deterioration of Graves’ ophthalmopathy. Thyroid. 2010;20(7):777-783.  https://doi.org/10.1089/thy.2010.1634
  23. Khong JJ, Finch S, De Silva C, et al. Risk factors for Graves’ orbitopathy; the Australian Thyroid-Associated Orbitopathy (ATOR) study. J Clin Endocrinol Metab. 2016;101(7):2716-2720. https://doi.org/10.1210/jc.2015-4294
  24. Jorde R, Sundsfjord J. Serum TSH levels in smoking and non-smoking patients. The 5th Tromsø study. Exp Clin Endocrinol Diabetes. 2006;114:343-347.  https://doi.org/10.1055/s-2006-924264
  25. Cawood TJ, Moriarty P, O’Farrelly C, O’Shea D. Smoking and thyroid-associated ophthalmopathy: A novel explanation of the biological link. J Clin Endocrinol Metab. 2007;92(1):59-64.  https://doi.org/10.1210/jc.2006-1824
  26. Quadbeck B, Roggenbuck U, Janssen OE, et al. Impact of smoking on the course of Graves’ disease after withdrawal of antithyroid drugs. Exp Clin Endocrinol Diabetes. 2006;114:406-411.  https://doi.org/10.1055/s-2006-924065
  27. Tallstedt L, Lundell G, Torring O, et al. Occurrence of ophthalmopathy after treatment for Graves’ hyperthyroidism. N Engl J Med. 1992;326:1733-1738. https://doi.org/10.1056/NEJM199206253262603
  28. Sisson JC, Schipper MJ, Nelson CC, et al. Therapy and Graves’ Ophthalmopathy. J Nuclear Medicine. 2008;49(6):923-930.  https://doi.org/10.2967/jnumed.107.049437
  29. Eckstein A, Plicht M, Lax H, et al. Thyrotropin receptor autoantibodies are independent risk factors for Graves’ ophthalmopathy and help to predict severity and outcome of the disease. J Clin Endocrinol Metabol. 2006;91(9): 3464-3470. https://doi.org/10.1210/jc.2005-2813
  30. Lantz M, Planck T, Asman P, Hallengren B. Increased TRAb and/or Low Anti-TPO Titers at Diagnosis of Graves’ Disease are Associated with an Increased Risk of Developing Ophthalmopathy after Onset. Exp Clin Endocrinol Diabetes. 2014;122:113-117.  https://doi.org/10.1055/s-0033-1363193
  31. Eckstein AK, Plicht M, Lax H, et al. Clinical results of anti-inflammatory therapy in Graves ophthalmopathy and association with thyroidal autoantibodies. Clin Endocrinol Oxf. 2004;61:612-618.  https://doi.org/10.1111/j.1365-22654.2004.02143.x
  32. Mancini A, Segni C, Raimondo S, et al. Thyroid Hormones, Oxidative Stress and Inflammation. Mediat Inflamm. 2016;1:1-12.  https://doi.org/10.1155/2016/6757154
  33. Perros, P, Kendall-Taylor P, Neoh C, et al. A prospective study of the effects of radioiodine therapy for hyperthyroidism in patients with minimally active Graves’ ophthalmopathy. J Clin Endocrinol Metabol. 2005;90(9):5321-5323. https://doi.org/10.1210/jc.2005-0507
  34. Vannucchi G, Covelli D, Campi I, et al. Prevention of orbitopathy by oral or intravenous steroid prophylaxis in short duration Graves’ disease patients undergoing radioiodine ablation: A prospective randomized control trial study. Thyroid. 2019;29(12):1828-1833. https://doi.org/10.1089/thy.2019.0150
  35. Ross DS, Burch HB, Cooper DS, et al. American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016;26(10):1343-1421. https://doi.org/10.1089/thy.2016.0229
  36. Sviridenko N, Sheremeta M, Grusha Y. International Symposium for Thyroid Eye Disease (June 2016, London). Clin Exper Thyroidol. 2017;12(3):12-19.  https://doi.org/10.14341/ket2016312-19
  37. Jensen BE, Bonnema SJ, Hegedus L. Glucocorticoids do not influence the effect of radioiodine therapy in Graves’ disease. Eur J Endocrinol. 2005; 153(1):15-21.  https://doi.org/10.1530/eje.1.01938
  38. Guo Z, Yu P, Liu Z, et al. Total thyroidectomy vs bilateral subtotal thyroidectomy in patients with Graves’ diseases: a meta-analysis of randomized clinical trials. Clin Endocrinol. 2013;79(5):739-746.  https://doi.org/10.1111/cen.12209
  39. Opoku-Boateng A, Wang TS, Sosa JA. Thyroidectomy in Patients with Graves’ Disease. In: Graves’ Disease. Vol 17. New York, NY: Springer New York; 2015. https://doi.org/10.1007/978-1-4939-2534-6_8
  40. Bartalena L, Macchia PE, Marcocci C, et al. Effects of treatment modalities for Graves’ hyperthyroidism on Graves’ orbitopathy: a 2015 Italian Society of Endocrinology Consensus Statement. J Endocrinol Invest. 2015; 38(4):481-487.  https://doi.org/10.1007/s40618-015-0257-z
  41. Marcocci C, Kahaly GJ, Krassas GE, et al. European Group on Graves Orbitopathy: Selenium and the course of mild Graves’ orbitopathy. N Engl J Med. 2011;364(20):1920-1931. https://doi.org/10.1056/NEJMoa101298
  42. Bartalena L. The dilemma of how to manage Graves’ hyperthyroidism in patients with associated orbitopathy. J Clin Endocrinol Metab. 2011;96(3):592-599.  https://doi.org/10.1210/jc.2010-2329
  43. Laurberg P, Berman DC, Andersen S, et al. Sustained control of Graves’ hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe Graves’ orbitopathy. Thyroid. 2011;21(9):951-956.  https://doi.org/10.1089/thy.2011.0039
  44. Elbers L, Mourits M, Wiersinga W. Outcome of very long-term treatment with antithyroid drugs in Graves’ hyperthyroidism associated with Graves’ orbitopathy. Thyroid. 2011;21(3):279-283.  https://doi.org/10.1089/thy.2010.0181
  45. Ismailova DS, Belovalova IM, Grusha YO, Sviridenko NS. Orbital decompression in the system of treatment for complicated thyroid eye disease: case report and literature review. Int Med Case Rep J. 2018;11:243-249.  https://doi.org/10.2147/IMCRJ.S164372

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